Escitalopram Oxalate - 10mM in DMSO , Serotonin transporter inhibitor, CAS No.219861-08-2, Serotonin transporter inhibitor

CAS: 219861-08-2 Cat. No.: E409043 Peso molecular: 414.43 Número EC: 620-544-8 PubChem CID: 146571

GRADE & PURITY 10mM in DMSO

Synonyms

5-Isobenzofurancarbonitrile, 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-, (1S)-, ethanedioate (1:1)

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Descripción general

Information

Escitalopram Oxalate Escitalopram Oxalate is a selective serotonin (5-HT) reuptake inhibitor (SSRI) with K i of 0.89 nM.
In vitro

Escitalopram, the S-enantiomer of citalopram, belongs to a class of antidepressant agents known as selective serotonin-reuptake inhibitors (SSRIs). It is used to treat the depression associated with mood disorders. It is also used on occassion in the treatment of body dysmorphic disorder and anxiety. The antidepressant, antiobsessive-compulsive, and antibulimic actions of escitalopram are presumed to be linked to its inhibition of CNS neuronal uptake of serotonin. In vitro studies show that escitalopram is a potent and selective inhibitor of neuronal serotonin reuptake and has only very weak effects on norepinephrine and dopamine neuronal reuptake. Escitalopram has no significant affinity for adrenergic (alpha1, alpha2, beta), cholinergic, GABA, dopaminergic, histaminergic, serotonergic (5HT1A, 5HT1B, 5HT2), or benzodiazepine receptors; antagonism of such receptors has been hypothesized to be associated with various anticholinergic, sedative, and cardiovascular effects for other psychotropic drugs. The chronic administration of escitalopram is found to downregulate brain norepinephrine receptors, as has been observed with other drugs effective in the treatment of major depressive disorder. Escitalopram does not inhibit monoamine oxidase.

In vivo

Cell Data

cell lines：H727 and BON

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

Sinónimos

5-Isobenzofurancarbonitrile, 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1, 3-dihydro-, (1S)-, ethanedioate (1:1)

Especificaciones y pureza

10mM in DMSO

Mecanismos bioquímicos y fisiológicos

Escitalopram Oxalate is a selective serotonin (5-HT) reuptake inhibitor (SSRI) with K_i of 0.89 nM.

Condiciones de almacenamiento de almacenamiento

Store at -80°C

Enviado en

Dry ice packs + Cold packs

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Tipo de acción

INHIBITOR

Mecanismo de acción

Serotonin transporter inhibitor

Nombres e identificadores

• Isómeros SMILES: CN(C)CCC[C@@]1(C2=C(CO1)C=C(C=C2)C#N)C3=CC=C(C=C3)F.C(=O)(C(=O)O)O
• WGK Alemania: 3
• CAS alternativo: 128196-01-0
• PubChem CID: 146571
• Peso molecular: 414.43

Objetivos asociados (humanos)

SLC6A4 Tclin Sodium-dependent serotonin transporter (1 Activities)

Discover Target: SLC6A4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Propiedades químicas y físicas

• Rotación específica [α]: 13° (C=1,MeOH)
• Punto de fusión (°C): 146 °C

Referencias

1. Tiantian Wang, Ruihe Zheng, Song Sun.  (2022)  Drug Repurposing: Escitalopram attenuates acute lung injury by inhibiting the SIK2/ HDAC4/ NF-κB signaling cascade.  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,      [PMID:35158201] [10.1016/j.bbrc.2022.02.015]