Ethylenebis(nitrilodimethylene)tetraphosphonic acid - ≥95% , CAS No.1429-50-1

CAS: 1429-50-1 Cat. No.: E409435 Peso molecular: 436.12 Número EC: 215-851-5

GRADE & PURITY ≥95%

Synonyms

(Ethylenedinitrilo)-tetramethylenephosphonic acid | AKOS000365812 | Hexasodium dihydrogen (ethane-1,2-diylbis(nitrilobis(methylene)))tetrakisphosphonate | N,N,N',N'-Ethylenediaminetetrakis(methylenephosphonic Acid) | DTXSID3061689 | NFDRPXJGHKJRLJ-UHFFFAO

Storage

Room temperature

Shipped In

Normal

Specifications

Sinónimos

(Ethylenedinitrilo)-tetramethylenephosphonic acid | AKOS000365812 | Hexasodium dihydrogen (ethane-1, 2-diylbis(nitrilobis(methylene)))tetrakisphosphonate | N, N, N', N'-Ethylenediaminetetrakis(methylenephosphonic Acid) | DTXSID3061689 | NFDRPXJGHKJRLJ-UHFFFAO

Especificaciones y pureza

≥95%

Condiciones de almacenamiento de almacenamiento

Room temperature

Enviado en

Normal

Pureza

≥95%

Nombres e identificadores

• Pubchem Sid: 504752625
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504752625
• Sonrisas canónicas: C(CN(CP(=O)(O)O)CP(=O)(O)O)N(CP(=O)(O)O)CP(=O)(O)O
• IUPAC Name: [2-[bis(phosphonomethyl)amino]ethyl-(phosphonomethyl)amino]methylphosphonic acid
• InChIKey: NFDRPXJGHKJRLJ-UHFFFAOYSA-N
• INCHI: 1S/C6H20N2O12P4/c9-21(10,11)3-7(4-22(12,13)14)1-2-8(5-23(15,16)17)6-24(18,19)20/h1-6H2,(H2,9,10,11)(H2,12,13,14)(H2,15,16,17)(H2,18,19,20)
• Isómeros SMILES: C(CN(CP(=O)(O)O)CP(=O)(O)O)N(CP(=O)(O)O)CP(=O)(O)O
• WGK Alemania: 1
• Peso molecular: 436.12
• Reaxy-Rn: 1810320
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1810320&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic acids and derivatives
    • Clase Organic phosphonic acids and derivatives
      • Subclass Organic phosphonic acids

• Kingdom: Organic compounds
• Superclass: Organic acids and derivatives
• Clase: Organic phosphonic acids and derivatives
• Subclass: Organic phosphonic acids
• Intermediate Tree Nodes: Not available
• Direct Parent: Organic phosphonic acids
• Alternative Parents: Organopnictogen compounds Organophosphorus compounds Organonitrogen compounds Organic oxides Hydrocarbon derivatives
• Molecular Framework: Aliphatic acyclic compounds
• Substituents: Organophosphonic acid - Organic nitrogen compound - Organic oxygen compound - Organopnictogen compound - Organic oxide - Hydrocarbon derivative - Organophosphorus compound - Organonitrogen compound - Aliphatic acyclic compound
• Descripción: This compound belongs to the class of organic compounds known as organic phosphonic acids. These are organic compounds containing phosphonic acid.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Objetivos asociados (no humanos)

Hdac6 Histone deacetylase 6 (222 Activities)

Discover Target: Hdac6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mecanismos de acción

Propiedades químicas y físicas

• Solubilidad: Soluble in water
• Punto de fusión (°C): 215-217°C
• Peso molecular: 436.120 g/mol
• XLogP3: -11.200
• Hydrogen Bond Donor Count: 8
• Hydrogen Bond Acceptor Count: 14
• Rotatable Bond Count: 11
• Exact Mass: 435.997 Da
• Monoisotopic Mass: 435.997 Da
• Topological Polar Surface Area: 237.000 Ų
• Heavy Atom Count: 24
• Formal Charge: 0
• Complexity: 486.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

Referencias

1. Lili Hao, Haoyang Ding, Xiangchuan Xu, Hongli Mao, Zhongwei Gu.  (2023)  Chelating ligand-bridged IO-Gd nanoparticles with enhanced contrast performance for dual-mode MRI.  JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY,      [PMID:] [10.1016/j.jmst.2023.10.030]

2. Wen Li, Wen Liu, Wendi Jia, Jin Zhang, Qi Zhang, Zhenguo Zhang, Jialin Zhang, Yunqi Li, Yiyang Liu, Haining Wang, Yan Xiang,, Shanfu Lu.  (2023)  Dual-Proton Conductor for Fuel Cells with Flexible Operational Temperature.  ADVANCED MATERIALS,      [PMID:38160326] [10.1002/adma.202310584]

3. Chenhao Ni, Ningyi Chen, Jiahui He, Meilan Pan, Xianhua Wang, Bingjun Pan.  (2023)  Complexation-based selectivity of organic phosphonates adsorption from high-salinity water by neodymium-doped nanocomposite.  WATER RESEARCH,      [PMID:37827040] [10.1016/j.watres.2023.120705]

4. Yongchao Miao, Shuming Wen, Zhenhao Guan, Qicheng Feng.  (2023)  Utilization of EDTMPA as an eco-friendly depressant for selective flotation separation of cassiterite from calcite in the oleate system.  COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,      [PMID:] [10.1016/j.colsurfa.2023.131933]

5. Yufei Wang, Na Wei, Jia Zeng, Yaochen Wu, Tong Zhou, Guohan Liu, Qiushan Liu, Jin Guo.  (2023)  Nitrogen-doped carbon nanotube modified ultrafiltration membrane activating peroxymonosulfate for catalytic transformation of phosphonate and mitigation of membrane fouling.  SEPARATION AND PURIFICATION TECHNOLOGY,      [PMID:] [10.1016/j.seppur.2023.123522]

6. Wen-Yuan Fan, Xin Zhang, Pu-Can Guo, Guo-Ping Sheng.  (2023)  Highly efficient removal of phosphonates by ferrate-induced oxidation coupled with in situ coagulation.  JOURNAL OF HAZARDOUS MATERIALS,      [PMID:36870127] [10.1016/j.jhazmat.2023.131104]

7. Shunlong Pan, Xinrui Guo, Xing Lu, Rong Li, Hao Hu, Xi Nie, Biming Liu, Rong Chen, Mingxin Zhu, Shengqiang Hei, Xianzheng Zhu, Shuo Zhang, Hua Zhou.  (2023)  Boosting peroxymonosulfate activation by a novel bifunctional core-shell nanoreactor MnFe2O4@HZO for nitrilotris-methylenephosphonic acid removal.  APPLIED CATALYSIS B-ENVIRONMENTAL,      [PMID:] [10.1016/j.apcatb.2023.122508]

8. Xukun Zhang, Fancheng Meng, Linquan Sun, Zhaowu Zhu, Desheng Chen, Lina Wang.  (2022)  Influence of Several Phosphate-Containing Additives on the Stability and Electrochemical Behavior of Positive Electrolytes for Vanadium Redox Flow Battery.  Energies,  15  (21): (7829).  [PMID:] [10.3390/en15217829]

9. Xiao-Lu Pu, Song Gu, Yan-Fang Xiao, Yu-Zhong Wang, Li Chen.  (2022)  Novel organophosphonate-decorated WS2 nanosheets towards flame retardancy and mechanical enhancement of epoxy resin.  POLYMER DEGRADATION AND STABILITY,      [PMID:] [10.1016/j.polymdegradstab.2022.110170]

10. Xiaoqing Qiu, Xule Wan, Zichun Wang, Zhiwei Li, Juan Li, Xiaohong Li, Zhijun Zhang.  (2022)  A simple and universal strategy for construction and application of silica-based flame-retardant nanostructure.  COMPOSITES PART B-ENGINEERING,      [PMID:] [10.1016/j.compositesb.2022.109887]

11. Wenduo Wang, Zhengzhou Wang.  (2022)  Functionalizing mesoporous silica with a nano metal–organic phosphonate towards mechanical-robust, thermal-resistant, and fire-safety epoxy resin.  POLYMERS FOR ADVANCED TECHNOLOGIES,  33  (5): (1496-1511).  [PMID:] [10.1002/pat.5616]

12. Qiang Chen, Zhengzhou Wang.  (2021)  A copper organic phosphonate functionalizing boron nitride nanosheet for PVA film with excellent flame retardancy and improved thermal conductive property.  COMPOSITES PART A-APPLIED SCIENCE AND MANUFACTURING,      [PMID:] [10.1016/j.compositesa.2021.106738]

13. Lili Hao, Peng Wang, Zhenxu Wu, Zongliang Wang, Yu Wang, Yongzhan Zhu, Zhiqiang Xu, Min Guo, Jiansong Ji, Peibiao Zhang.  (2021)  EDTMP ligand-enhanced water interactions endowing iron oxide nanoparticles with dual-modal MRI contrast ability.  Journal of Materials Chemistry B,  9  (43): (9055-9066).  [PMID:34673872] [10.1039/D1TB01677F]

14. Lei Chen, Huan Wang, Xiaohong Cao, Yue Feng, Zhibing Zhang, Youqun Wang, Yunhai Liu.  (2021)  Effects of different phosphorus sources on the adsorption of U(Ⅵ) by Zr(Ⅳ) organophosphate hybrids.  JOURNAL OF SOLID STATE CHEMISTRY,      [PMID:] [10.1016/j.jssc.2021.122434]

15. Bi Lin, Jun Liu, Yanxing Wang, Fan Yang, Liyu Huang, Ruichan Lv.  (2020)  Enhanced Upconversion Luminescence-Guided Synergistic Antitumor Therapy Based on Photodynamic Therapy and Immune Checkpoint Blockade.  CHEMISTRY OF MATERIALS,      [PMID:] [10.1021/acs.chemmater.0c01031]

16. Chun Ding, Xuan Zhang, Shu Xiong, Liang Shen, Ming Yi, Boyang Liu, Yan Wang.  (2019)  Organophosphonate draw solution for produced water treatment with effectively mitigated membrane fouling via forward osmosis.  JOURNAL OF MEMBRANE SCIENCE,      [PMID:] [10.1016/j.memsci.2019.117429]

17. Shu Wang, Shuhui Sun, Chao Shan, Bingcai Pan.  (2019)  Analysis of trace phosphonates in authentic water samples by pre-methylation and LC-Orbitrap MS/MS.  WATER RESEARCH,      [PMID:31181449] [10.1016/j.watres.2019.05.099]

18. Yongquan Luo, Lei Zhang, Lingyi Zhang, Bohao Yu, Yajie Wang, Weibing Zhang.  (2019)  Multiporous Terbium Phosphonate Coordination Polymer Microspheres as Fluorescent Probes for Trace Anthrax Biomarker Detection.  ACS Applied Materials & Interfaces,      [PMID:30951283] [10.1021/acsami.9b01123]

19. Shuhui Sun, Shu Wang, Yuxuan Ye, Bingcai Pan.  (2019)  Highly efficient removal of phosphonates from water by a combined Fe(III)/UV/co-precipitation process.  WATER RESEARCH,      [PMID:30685633] [10.1016/j.watres.2019.01.007]

20. Liang Shen, Fangqian Wang, Lian Tian, Xuan Zhang, Chun Ding, Yan Wang.  (2018)  High-performance thin-film composite membranes with surface functionalization by organic phosphonic acids.  JOURNAL OF MEMBRANE SCIENCE,      [PMID:] [10.1016/j.memsci.2018.05.071]

21. Yuhua Dong, Yutong Xie, Jiaqi Yu, Wenjiao Zhang, Xueyan Du, Qiong Zhou.  (2024)  A novel anti-scaling and protection coating based on hollow periodic mesoporous organosilica encapsulated with scale inhibitor.  PROGRESS IN ORGANIC COATINGS,      [PMID:] [10.1016/j.porgcoat.2024.108942]

22. Hui-Song Hu, Tian-Yu Zhao, Hao Li, Hai-Jing Sun, Lian-Kui Wu, Fa-He Cao.  (2025)  A novel organic-reinforced zirconium-based composite conversion coating with long-term corrosion resistance property for ADC12 aluminum alloy.  Surfaces and Interfaces,      [PMID:] [10.1016/j.surfin.2025.106301]

23. Changxin Dong, Xinhuan Niu, Chao He, Xinjie Li, Zheng Wu, Jiahui Li, Bin Hu, Yunhui Shi, Jiabao Cheng, Xiaodong Luan.  (2024)  Effects of organic compounds rich in phosphate functional groups as multifunctional inhibitors on copper film chemical-mechanical polishing properties: Combined experiment and theoretical calculation.  TRIBOLOGY INTERNATIONAL,      [PMID:] [10.1016/j.triboint.2024.110276]

24. Tingting Xiang, Qingchao Zhu, Tanyu Zhou, Chenglong Chen, Ruibo Wang, Tieyu Hu, Bing Li, Ziwei Xu, Juan Yang.  (2024)  Tailoring ORR Activity in Fe−N−C Catalysts through Phosphorus Incorporation.  CHEMISTRY-A EUROPEAN JOURNAL,      [PMID:39512148] [10.1002/chem.202403162]

25. Zhou Chengwang, Ding Zhezheng, Ying Shengzhe, Jiang Hao, Wang Yan, Fang Timing, Zhang You, Sun Bing, Tang Xiao, Liu Xiaomin.  (2024)  Electrode/Electrolyte Optimization-Induced Double-Layered Architecture for High-Performance Aqueous Zinc-(Dual) Halogen Batteries.  Nano-Micro Letters,  17  (1): (1-17).  [PMID:39509032] [10.1007/s40820-024-01551-w]

26. Chengyi Wang, Siyue Xue, Yubo Xu, Ran Li, Yangbo Qiu, Chao Wang, Long-Fei Ren, Jiahui Shao.  (2024)  Novel electrocatalytic capacitive deionization with catalytic electrodes for selective phosphonate degradation: Performance and mechanism.  WATER RESEARCH,      [PMID:38657308] [10.1016/j.watres.2024.121614]

27. Wen Li, Jiajie Fang, Zhi Mao, Shanfu Lu, Yan Xiang.  (2025)  Dispersion engineering of ethylenediamine tetramethylene phosphonic acid in composite Membranes: Toward enhanced proton conductivity and phosphoric acid retention for high-temperature proton exchange membranes.  JOURNAL OF MEMBRANE SCIENCE,      [PMID:] [10.1016/j.memsci.2025.124388]

28. Wubin Liao, Peng Liao, Zheng Wang, Chenggang Ci, Shiwei Xie.  (2025)  New insight to phosphonate degradation by electrochlorination: Hypochlorous acid dominated dephosphorylation through selective attacking CP bond.  SEPARATION AND PURIFICATION TECHNOLOGY,      [PMID:] [10.1016/j.seppur.2025.132958]

29. Shuai Yang, Lin Zhang, Yibing Sun, Zhichao Yang, Hongchao Li.  (2025)  Nonradical degradation of phosphonates to orthophosphate via surface-activated peroxides on carbon nanotubes.  SEPARATION AND PURIFICATION TECHNOLOGY,      [PMID:] [10.1016/j.seppur.2025.133242]

30. Wenfang Cui, Mei Ma, Yongmei Sun, Qingwen Fan, KeYu Zhang, Chengcheng Shi.  (2025)  Porous TiP2O7/nitrogen-doped carbon composite with tailored crystal orientation as diffusion-controlled high-rate anode for lithium-ion batteries.  JOURNAL OF COLLOID AND INTERFACE SCIENCE,      [PMID:40174286] [10.1016/j.jcis.2025.137469]

31. Feixiang Chen, Youqun Wang, Weiqian Cai, Zhibin Zhang, Xiaohong Cao, Yunhai Liu.  (2025)  Efficient adsorptive removal of U(VI) using zirconium phosphate decorated by ethylenediaminetetramethylene phosphonic acid.  Journal of Water Process Engineering,      [PMID:] [10.1016/j.jwpe.2025.108105]

32. Xican Xu, Xing Sun, Zhaohui Qin, Qingyuan Wu, Hongyu Wang, Yali Chang, Jiayu Yang, Shunhao Wang, Hongwei Hou, Xin Su, Huiyu Liu.  (2025)  Nanozyme-powered detection platform for pyrophosphate and related biomarkers.  CHEMICAL ENGINEERING JOURNAL,      [PMID:] [10.1016/j.cej.2025.171761]

33. Wenfang Cui, Yongmei Sun, KeYu Zhang, Chengcheng Shi, Peng Fu, Mei Ma.  (2026)  Ionic liquid-mediated concurrent oxygen vacancies and N-doped carbon in hierarchical TiP2O7 for lithium storage.  CHEMICAL ENGINEERING JOURNAL,      [PMID:] [10.1016/j.cej.2026.174155]

34. Lingyun Bao, Wengang Liu, Wenbao Liu, Yong Mao, Yanbai Shen.  (2026)  Selective depression of activated sphalerite using organic phosphonate depressants: Role of functional group.  JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY,      [PMID:] [10.1016/j.jiec.2026.02.020]

35. Huihui Peng, Mengchun Zhou, Yan Zhang, Ankang Wang, Chenying Zhou, Chuanshu He, Yongjia Lei, Peng Zhou, Bo Lai.  (2026)  Self-enhanced phosphonate degradation in mZVI/air-Fenton process: The role of coordination for mZVI corrosion and iron-sludge reduction.  WATER RESEARCH,      [PMID:41785790] [10.1016/j.watres.2026.125606]

36. Ningyi Chen, Ying Xu, Dan Wang, Ge Zhao, Kehao Huang, Bingjun Pan.  (2026)  Nanogold Array Sensors Leveraging Interaction-Sensitive UV Shifts for Portable Speciation of Phosphorus in Water.  ENVIRONMENTAL SCIENCE & TECHNOLOGY,      [PMID:41725160] [10.1021/acs.est.5c17656]

37. Meng Zhang, Xuewei Li, Jiuyang Lin, Yinhua Wan, Weijie Song.  (2026)  Selective enrichment of rare earth ions from high-magnesium/calcium leaching solutions via extraction-precipitation.  Journal of Environmental Chemical Engineering,      [PMID:] [10.1016/j.jece.2026.122016]

38. Shiwei Xie, Zheng Wang, Na Zhang, Wenlu Li, Peng Liao.  (2026)  Sequential Oxidation and Crystallization Based on Split-flow Electrochemical Oxidation with Rapid Filtration for Sustainable Phosphate Recovery from Phosphonate.  WATER RESEARCH,      [PMID:] [10.1016/j.watres.2026.125782]