Exendin (5-39) - ≥99% , CAS No.196109-27-0

CAS: 196109-27-0 Cat. No.: E647553 Peso molecular: 3806.30

GRADE & PURITY ≥99%

Storage

Protected from light,Argon charged,Desiccated,Store at -80°C

Shipped In

Dry ice packs + Cold packs

Descripción general

Exendin (5-39) is a potent Glukagon-like peptide 1 ( GLP-1 ) receptor antagonist. Exendin (5-39) improves memory impairment in β-amyloid protein-treated rats

In Vivo

Exendin (5-39) (intracerebroventricular injection; 0.3 μg; once daily; 1-week) increases GLT-1 protein levels in the hippocampus of male Wistar rats. Additionally, hippocampal slices are prepared from Ex-treated or vehicle rats,Exendin (5-39) decreases fEPSP decay time and increases the input-output relation and decreased the paired-pulse ratio in the dentate gyrus (DG). Furthermore, Ex inhibits long-term depression but not long-term potentiation in the DG . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Wistar rats (3 weeks old and 18 days pregnant) Dosage: 0.3 μg Administration: Intracerebroventricular injection; 0.3 μg; once daily; 1-week Result: Inhibited GLT-1 protein levels and inhibited long-term depression in rats.

Form:Solid

IC50& Target:IC50: GLP-1 receptor

Specifications

Especificaciones y pureza

≥99%

Mecanismos bioquímicos y fisiológicos

Exendin (5-39) is a potent Glukagon-like peptide 1 ( GLP-1 ) receptor antagonist. Exendin (5-39) improves memory impairment in β-amyloid protein-treated rats.

Condiciones de almacenamiento de almacenamiento

Protected from light, Argon charged, Desiccated, Store at -80°C

Enviado en

Dry ice packs + Cold packs

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Tipo de acción

ANTAGONIST

Pureza

≥99%

Nombres e identificadores

• Peso molecular: 3806.30