Chronic Lymphocytic Leukemia Detection Test
Chronic Lymphocytic Leukemia Detection Test
Chronic lymphocytic leukemia (chronic lymphatic cbronic lymphvcytic leukemia cll) is a malignant proliferative disease of lymphocytes in the lymphatic system with certain immune insufficiencies, applying monoclonal antibody for immunophenotyping of chronic lymphatic, 85% of them belong to the B-cell type, and the others are the non-T-non-B and T-cell type, the experiment is derived from the undergraduate 5-year testing program of Mudanjiang Medical College. Laboratory instruction
Operation method
Chronic Lymphocytic Leukemia Detection Test
Principle
Chronic lymphocytic leukemia (chronic lymphocytic cbronic lymphvcytic leukemia cll) is a malignant proliferative disease of lymphocytes in the lymphatic system with certain immune insufficiencies, applying monoclonal antibodies to immunophenotyping of chronic lymphocytes, 85% of them belong to the B-cell type, and the others are the non-T non-B-type and the T-cell type. Move Hematology: For more product details, please visit Aladdin Scientific website.
1. Red blood cells and platelets may be normal in the early stages of the disease and decrease in the later stages.
2. autoimmune hemolytic anemia may complicate about 10-20% of patients, when the anemia is aggravated.
3. the total number of leukocytes is mostly 10×109/L, and a few of them are more than 100×109/L. Most of them are mature small lymphocytes, which can account for 65-75% in early stage, and up to 90-98% in late stage, whose morphology is indistinguishable from that of normal small lymphocytes, and large lymphocytes can be seen occasionally, whose morphology has no obvious abnormality. The morphology is indistinguishable from that of normal small lymphocytes, and occasionally large lymphocytes are seen with no obvious abnormalities in their morphology. Young lymphocytes with loose nuclear chromatin and obvious nucleoli are also one of the features of slow gonorrhea.
Bone marrow image: lymphocytes increase significantly, accounting for more than 40%, cell size and morphology are basically consistent with the periphery. In the early stage of the disease. In the early stage of the disease, all kinds of hematopoietic cells can be seen in the bone marrow, but in the late stage, almost all of them are lymphocytes, and the prolymphocytes are not more than 1-2%, and the young lymphocytes are similar to those in the peripheral blood. The granulocyte and erythrocyte lineages are reduced, and megakaryocytes are also reduced in the late stage. When hemolysis occurs, young erythrocytes can be significantly increased. Bone marrow biopsy shows focal or diffuse wetting of lymphocytes. Morphological characteristics of leukemic lymphocytes: proliferation of mature lymphocytes is dominant, morphological abnormalities are not obvious, the cytosol is slightly large and friable, blue cells are easily seen, the nuclear chromatin is dense, the nucleolus is inconspicuous or absent, and the nucleus has a deep fissure, most of the cytoplasm is abundant, alkalophilic, and granulomatous, and a few of them have little cytoplasm, and Auer's vesicles are seen only in the fissure of the nucleus or in the notch.