Cephalosporinases are β-lactamase phenotypes characterized by preferential hydrolysis of cephalosporins and play a major role in antimicrobial resistance among Gram-negative bacteria.
β-Lactamases are a family of enzymes that hydrolyze the β-lactam ring and inactivate β-lactam antibacterial agents, constituting a major molecular basis for acquired bacterial resistance. β-Lactam antibiotics primarily target penicillin-binding proteins (PBPs) and disrupt peptidoglycan ...
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