Artículos por tema "cytotoxic T cells"

1. Granzyme A and Granzyme B Signaling Pathways: Cytotoxic Effects and Immune Regulatory Mechanisms
   posted this at 22 jun 2026

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   Granzyme A (GZMA) and Granzyme B (GZMB) are serine proteases released by cytotoxic T cells, natural killer cells, and some NKT cells. They are key effector molecules in the perforin–granzyme cytotoxic system. GZMB is mainly associated with caspase-dependent apoptosis, the Bid–mitochondrial ...
2. Killer T Cell-Mediated Apoptosis Pathway: Recognition, Effector Molecule Release, and Target Cell Death Mechanisms
   posted this at 22 jun 2026

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   The killer T cell-mediated apoptosis pathway mainly refers to the process by which CD8⁺ cytotoxic T lymphocytes (CTLs) recognize abnormal target cells and induce target cell apoptosis through the perforin-granzyme axis, the Fas/FasL death receptor axis, and TNF-related signaling. This pathway ...