Ferroptosis is a form of metabolic cell death jointly driven by disruption of iron homeostasis, accumulation of membrane lipid peroxidation, and failure of lipid antioxidant defense systems.
The GPX family constitutes an important enzymatic system in the regulation of cellular redox homeostasis and participates in peroxide clearance, termination of lipid peroxidation, maintenance of membrane homeostasis, and control of stress-induced injury. Different members exhibit clear ...
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