Plasma proteins do not merely maintain colloid osmotic pressure or serve as passive carriers, but instead constitute a core functional layer in the circulatory system for metal coordination, inflammatory reprogramming, and injury buffering. Transferrin, ceruloplasmin, albumin, haptoglobin, and ...
Haptoglobin (Hp) is an α2-globulin glycoprotein primarily synthesized by hepatocytes and secreted into plasma. Hp binds free hemoglobin (Hb) released during intravascular hemolysis with high affinity, forming Hp–Hb complexes that are cleared via receptor-mediated pathways (notably CD163). ...
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