≥96%, A solution in ethanol for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -20°C,Argon charged Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Farnesyl Thiosalicylic Acid Amide, association of Ras protein to the inner surface of the plasma membrane is required for Ras signaling activity. Farnesyl thiosalicylic acid (FTS) inhibits Ras-mediated signaling by dislodging Ras from the cell membrane thereby rendering it susceptible to proteolytic degradation. FTS amide is an FTS derivative with an amide added to the carboxyl group. FTS amide inhibits the growth of U87 and Panc-1 tumor cells with IC50values of 10 and 20 μM, respectively, a relatively higher potency compared to that of FTS (IC50s = 50 and 35 μM, respectively). Treatment of nude mice bearing either Panc-1 or U87 glioblastoma tumors with 100 mg/kg FTS-amide twice daily for four days inhibits tumor growth by at least 50% of controls.
application：
Farnesyl Thiosalicylic Acid Amide is a Ras-mediated signaling inhibitor.
| Sonrisas canónicas | CC(=CCCC(=CCCC(=CCSC1=CC=CC=C1C(=O)N)C)C)C |
|---|---|
| IUPAC Name | 2-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trienyl]sulfanylbenzamide |
| InChIKey | GZTMFRUGZMZCRD-CFBAGHHKSA-N |
| INCHI | 1S/C22H31NOS/c1-17(2)9-7-10-18(3)11-8-12-19(4)15-16-25-21-14-6-5-13-20(21)22(23)24/h5-6,9,11,13-15H,7-8,10,12,16H2,1-4H3,(H2,23,24)/b18-11+,19-15+ |
| Isómeros SMILES | CC(=CCC/C(=C/CC/C(=C/CSC1=CC=CC=C1C(=O)N)/C)/C)C |
| Número ONU | 1230 |
| Grupo de embalaje | II |
| Peso molecular | 357.55 |
Comprehensive hazard, handling, storage, and regulatory compliance document.
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View spec sheet →Taxonomy Tree
| Kingdom | Organic compounds |
|---|---|
| Superclass | Lipids and lipid-like molecules |
| Clase | Prenol lipids |
| Subclass | Sesquiterpenoids |
| Intermediate Tree Nodes | Not available |
| Direct Parent | Sesquiterpenoids |
| Alternative Parents | O-sulfanylbenzoic acids and derivatives Benzamides Thiophenol ethers Benzoyl derivatives Alkylarylthioethers Vinylogous thioesters Primary carboxylic acid amides Sulfenyl compounds Organooxygen compounds Organonitrogen compounds Organic oxides Hydrocarbon derivatives |
| Molecular Framework | Aromatic homomonocyclic compounds |
| Substituents | Sesquiterpenoid - Farsesane sesquiterpenoid - O-sulfanylbenzoic acid or derivatives - Benzamide - Benzoic acid or derivatives - Aryl thioether - Benzoyl - Thiophenol ether - Alkylarylthioether - Benzenoid - Vinylogous thioester - Monocyclic benzene moiety - Primary carboxylic acid amide - Carboxamide group - Thioether - Carboxylic acid derivative - Sulfenyl compound - Organosulfur compound - Organooxygen compound - Organonitrogen compound - Hydrocarbon derivative - Organic oxide - Organic oxygen compound - Organic nitrogen compound - Aromatic homomonocyclic compound |
| Descripción | This compound belongs to the class of organic compounds known as sesquiterpenoids. These are terpenes with three consecutive isoprene units. |
| External Descriptors | Not available |
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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| Solubilidad | Soluble in DMSO (~10 mg/ml), and DMF (~10 mg/ml). |
|---|---|
| Índice de refracción | n20D1.56 (Predicted) |
| Punto de ebullición (°C) | 78° C |
| Peso molecular | 357.600 g/mol |
| XLogP3 | 6.500 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 2 |
| Rotatable Bond Count | 10 |
| Exact Mass | 357.213 Da |
| Monoisotopic Mass | 357.213 Da |
| Topological Polar Surface Area | 68.400 Ų |
| Heavy Atom Count | 25 |
| Formal Charge | 0 |
| Complexity | 500.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 2 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 2 |
| Covalently-Bonded Unit Count | 1 |
K2218984