FFN511 - ≥98% , CAS No.1004548-96-2

CAS: 1004548-96-2 Cat. No.: F274714 Peso molecular: 284.35

GRADE & PURITY ≥98%

Synonyms

9-(2-aminoethyl)-2,3,6,7-tetrahydro-1H-pyrano[2,3-f]pyrido[3,2,1-ij]quinolin-11(5H)-one

Storage

Store at -20°C,Desiccated

Shipped In

Ice chest + Ice pads

Descripción general

FFN511 is a potent fluorescent false neurotransmitters (FFNs) that targets neuronal vesicular monoamine transporter 2 (VMA T2). FFN511 inhibits serotonin binding to VMA T2-containing membranes with an IC50 of 1 µM. FFN511 directly images the dynamics of release during exocytosis, can be used to label dopamine terminals in live cortical-striatalacute slices。

Specifications

Sinónimos

9-(2-aminoethyl)-2, 3, 6, 7-tetrahydro-1H-pyrano[2, 3-f]pyrido[3, 2, 1-ij]quinolin-11(5H)-one

Especificaciones y pureza

≥98%

Mecanismos bioquímicos y fisiológicos

First novel fluorescent false neurotransmitter. Enables optical imaging of presynaptic terminal activity. Inhibits 5-HT binding to VMAT2 (IC 50 = 1 µM (comparable to dopamine itself)). Released via exocytosis in the striatum in mouse acute slice preparati

Condiciones de almacenamiento de almacenamiento

Store at -20°C, Desiccated

Enviado en

Ice chest + Ice pads

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Tipo de acción

INHIBITOR

Nota

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. To make a 10 μM solution for slice incubation, 25 μl of a 20 mM FFN511 stock solution in DMSO is added to 50 ml of ACSF. This results in a 10 μM FFN511 solution in ACSF containing 0.05% DMSO. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Pureza

≥98%

Nombres e identificadores

• Sonrisas canónicas: C1CC2=CC3=C(C4=C2N(C1)CCC4)OC(=O)C=C3CCN.C(=O)(C(F)(F)F)O
• IUPAC Name: 6-(2-aminoethyl)-3-oxa-13-azatetracyclo[7.7.1.02,7.013,17]heptadeca-1(17),2(7),5,8-tetraen-4-one;2,2,2-trifluoroacetic acid
• InChIKey: XHUSAIWAUAMZRG-UHFFFAOYSA-N
• INCHI: 1S/C17H20N2O2.C2HF3O2/c18-6-5-11-10-15(20)21-17-13-4-2-8-19-7-1-3-12(16(13)19)9-14(11)17;3-2(4,5)1(6)7/h9-10H,1-8,18H2;(H,6,7)
• Isómeros SMILES: C1CC2=CC3=C(C4=C2N(C1)CCC4)OC(=O)C=C3CCN.C(=O)(C(F)(F)F)O
• Peso molecular: 284.35
• Reaxy-Rn: 23051490
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=23051490&ln=

Propiedades químicas y físicas

• Solubilidad: Soluble in DMSO to 100 mM and in ethanol to 100 mM

Referencias

1. Chen Zhou, Feifei Wu, Liqing He, Huijie Yan, Zhaowei Zhang, Shuang Zhao, Wenyi Huang, Yuhao Luo, Wei Zhao, Bulong Gao, Zherui Zhang, Yaofeng Zhou, Baiheng Wu, Junqiu Liu, Dingcheng Zhu.  (2025)  An Implant-Free Nanosystem Enabling Synergistic Oxidative Damage Mitigation and Deep Brain Stimulation for Alleviating Parkinsonian Symptoms.  ACS Nano,      [PMID:40664603] [10.1021/acsnano.5c06227]