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Synonyms
(((1-Chloro-4-hydroxyisoquinolin-3-yl)carbonyl)amino)acetic acid | 1-Chloro-N- (hydroxyformylmethyl-4-hydroxyisoquinoline-3-carboxamide | A899534 | Isoquinoline 3 | 4ie6 | SCHEMBL522744 | DB08687 | IOX3;YM311 | FG 2216 | SCHEMBL166144 | [(1-Chloro-4-hydro
Shipped In
Ice chest + Ice pads
Descripción general Information
FG-2216 FG-2216 is a potent, and orally active HIF prolyl 4-hydroxylase inhibitor with IC50 of 3.9 μM for PHD2 . Phase 2.
Targets
PHD2 (Cell-free assay) 3.9 μM
In vitro
FG-2216 shows the ability to stabilize HIF-α to stimulate EPO secretion.
In vivo
In male rhesus macaques, FG-2216 (60 mg/kg, p.o.), induces significant and reversible Epo induction, and induces a small elevation of HbF expression.
Specifications Sinónimos
(((1-Chloro-4-hydroxyisoquinolin-3-yl)carbonyl)amino)acetic acid | 1-Chloro-N- (hydroxyformylmethyl-4-hydroxyisoquinoline-3-carboxamide | A899534 | Isoquinoline 3 | 4ie6 | SCHEMBL522744 | DB08687 | IOX3;YM311 | FG 2216 | SCHEMBL166144 | [(1-Chloro-4-hydro
Especificaciones y pureza
≥96%
Mecanismos bioquímicos y fisiológicos
FG-2216 is a potent, and orally active HIF prolyl 4-hydroxylase inhibitor with IC50 of 3.9 μM for PHD2. Phase 2.
Condiciones de almacenamiento de almacenamiento
Store at -20°C
Enviado en
Ice chest + Ice pads
Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.
Propiedades del producto ALogP 1.337 hba_count 3 Recuento HBD 2 Enlace rotable 3
Nombres e identificadores Pubchem Sid 504764330 Pubchem Sid Url https://pubchem.ncbi.nlm.nih.gov/substance/504764330 Sonrisas canónicas C1=CC=C2C(=C1)C(=C(N=C2Cl)C(=O)NCC(=O)O)O IUPAC Name 2-[(1-chloro-4-hydroxyisoquinoline-3-carbonyl)amino]acetic acid InChIKey OUQVKRKGTAUJQA-UHFFFAOYSA-N INCHI 1S/C12H9ClN2O4/c13-11-7-4-2-1-3-6(7)10(18)9(15-11)12(19)14-5-8(16)17/h1-4,18H,5H2,(H,14,19)(H,16,17) Isómeros SMILES C1=CC=C2C(=C1)C(=C(N=C2Cl)C(=O)NCC(=O)O)O Peso molecular 280.66 Reaxy-Rn 10565114 Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=10565114&ln=
Documentation 📋 Safety Data Sheet (SDS) Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS → ✅ Certificate of Analysis (COA) Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA → 📊 Datasheet Quick-reference summary of product specifications and applications.
View datasheet → 🔬 Specification Sheet Full quality attributes and acceptance criteria for this grade.
View spec sheet →
Advanced Data Taxonomic Classification Kingdom Organic compounds Superclass Organic acids and derivatives Clase Carboxylic acids and derivatives Subclass Amino acids, peptides, and analogues Intermediate Tree Nodes Amino acids and derivatives - Alpha amino acids and derivatives - N-acyl-alpha amino acids and derivatives Direct Parent N-acyl-alpha amino acids Alternative Parents Isoquinolines and derivatives Pyridinecarboxylic acids and derivatives 2-heteroaryl carboxamides 2-halopyridines Hydroxypyridines Aryl chlorides Benzenoids Heteroaromatic compounds Vinylogous acids Secondary carboxylic acid amides Monocarboxylic acids and derivatives Carboxylic acids Azacyclic compounds Organonitrogen compounds Organopnictogen compounds Hydrocarbon derivatives Carbonyl compounds Organic oxides Organochlorides Molecular Framework Aromatic heteropolycyclic compounds Substituents N-acyl-alpha-amino acid - Isoquinoline - Pyridine carboxylic acid or derivatives - 2-heteroaryl carboxamide - 2-halopyridine - Hydroxypyridine - Aryl chloride - Aryl halide - Pyridine - Benzenoid - Heteroaromatic compound - Vinylogous acid - Carboxamide group - Secondary carboxylic acid amide - Carboxylic acid - Monocarboxylic acid or derivatives - Azacycle - Organoheterocyclic compound - Organochloride - Organohalogen compound - Hydrocarbon derivative - Organic nitrogen compound - Organic oxide - Organopnictogen compound - Organonitrogen compound - Organooxygen compound - Organic oxygen compound - Carbonyl group - Aromatic heteropolycyclic compound Descripción This compound belongs to the class of organic compounds known as n-acyl-alpha amino acids. These are compounds containing an alpha amino acid which bears an acyl group at its terminal nitrogen atom. External Descriptors Not available Data sources 1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.
Estructura 3D Objetivos asociados (humanos) Objetivos asociados (no humanos) Mecanismos de acción Certificados (CoA, COO, BSE/TSE y tabla de análisis) Propiedades químicas y físicas Solubilidad Solubility (25°C) In vitro DMSO: 56 mg/mL (199.52 mM); Water: Insoluble; Ethanol: Insoluble; DMSO (mg/ml) Solubilidad máxima 56 DMSO (mM) Solubilidad máxima 199.52968 Agua (mg/ml) Solubilidad máxima ＜1 Peso molecular 280.660 g/mol XLogP3 2.500 Hydrogen Bond Donor Count 3 Hydrogen Bond Acceptor Count 5 Rotatable Bond Count 3 Exact Mass 280.025 Da Monoisotopic Mass 280.025 Da Topological Polar Surface Area 99.500 Ų Heavy Atom Count 19 Formal Charge 0 Complexity 366.000 Isotope Atom Count 0 Defined Atom Stereocenter Count 0 Undefined Atom Stereocenter Count 0 Defined Bond Stereocenter Count 0 Undefined Bond Stereocenter Count 0 The total count of all stereochemical bonds 0 Covalently-Bonded Unit Count 1
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