FH1 (BRD-K4477) - ≥98% , CAS No.2719-05-3

CAS: 2719-05-3 Cat. No.: F413757 Peso molecular: 282.34 Número EC: 665-398-6

GRADE & PURITY ≥98%

Synonyms

N,N'-AcetylMDA | AC-33028 | N,N'-Diacetyl-4,4'-diaminodiphenylmethane | Paroil chlorez | Acetamide,N'-(methylenedi-4,1-phenylene)bis- | N,N'-(Methylenedi-4,1-phenylene)bis- acetamide | N-[4-[(4-acetamidophenyl)methyl]phenyl]acetamide | AM85691 | AKOS00281

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Descripción general

Information

FH1 (BRD-K4477) is a small molecule, which promotes differentiation of iPS-derived hepatocytes.

In vitro

FH1(BRD-K4477) enhances hepatocyte functions, and promotes the maturation of well-differentiated cultures of iHeps, which potentially alleviates a major obstacle to the use of iPS cells as a renewable source of functional human hepatocytes.

Specifications

Sinónimos

N, N'-AcetylMDA | AC-33028 | N, N'-Diacetyl-4, 4'-diaminodiphenylmethane | Paroil chlorez | Acetamide, N'-(methylenedi-4, 1-phenylene)bis- | N, N'-(Methylenedi-4, 1-phenylene)bis- acetamide | N-[4-[(4-acetamidophenyl)methyl]phenyl]acetamide | AM85691 | AKOS00281

Especificaciones y pureza

≥98%

Condiciones de almacenamiento de almacenamiento

Store at -20°C

Enviado en

Ice chest + Ice pads

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Pureza

≥98%

Nombres e identificadores

• Pubchem Sid: 504756248
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504756248
• Sonrisas canónicas: CC(=O)NC1=CC=C(C=C1)CC2=CC=C(C=C2)NC(=O)C
• IUPAC Name: N-[4-[(4-acetamidophenyl)methyl]phenyl]acetamide
• InChIKey: OEXMNSOPAKOPEF-UHFFFAOYSA-N
• INCHI: 1S/C17H18N2O2/c1-12(20)18-16-7-3-14(4-8-16)11-15-5-9-17(10-6-15)19-13(2)21/h3-10H,11H2,1-2H3,(H,18,20)(H,19,21)
• Isómeros SMILES: CC(=O)NC1=CC=C(C=C1)CC2=CC=C(C=C2)NC(=O)C
• Peso molecular: 282.34
• Reaxy-Rn: 2815695
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=2815695&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Benzenoids
    • Clase Benzene and substituted derivatives
      • Subclass Diphenylmethanes

• Kingdom: Organic compounds
• Superclass: Benzenoids
• Clase: Benzene and substituted derivatives
• Subclass: Diphenylmethanes
• Intermediate Tree Nodes: Not available
• Direct Parent: Diphenylmethanes
• Alternative Parents: Acetanilides N-acetylarylamines Acetamides Secondary carboxylic acid amides Organopnictogen compounds Organic oxides Hydrocarbon derivatives Carbonyl compounds
• Molecular Framework: Aromatic homomonocyclic compounds
• Substituents: Diphenylmethane - Acetanilide - N-acetylarylamine - Anilide - N-arylamide - Acetamide - Carboxamide group - Secondary carboxylic acid amide - Carboxylic acid derivative - Organic oxide - Organooxygen compound - Organonitrogen compound - Organopnictogen compound - Organic nitrogen compound - Organic oxygen compound - Carbonyl group - Hydrocarbon derivative - Aromatic homomonocyclic compound
• Descripción: This compound belongs to the class of organic compounds known as diphenylmethanes. These are compounds containing a diphenylmethane moiety, which consists of a methane wherein two hydrogen atoms are replaced by two phenyl groups.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Objetivos asociados (no humanos)

Hdac6 Histone deacetylase 6 (222 Activities)

Discover Target: Hdac6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mecanismos de acción

Propiedades químicas y físicas

• Solubilidad: DMSO: 52 mg/mL (184.2 mM) Ethanol: <1 mg/mL
• Peso molecular: 282.340 g/mol
• XLogP3: 2.500
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• Exact Mass: 282.137 Da
• Monoisotopic Mass: 282.137 Da
• Topological Polar Surface Area: 58.200 Ų
• Heavy Atom Count: 21
• Formal Charge: 0
• Complexity: 320.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1