Fluorescein5(6)-isothiocyanate（FITC） - ≥95%, mixture of 5- and 6- isomers , CAS No.27072-45-3

CAS: 27072-45-3 Cat. No.: F106837 Peso molecular: 389.38 Beilstein Registry Number: 1407295 Número EC: 248-207-7

GRADE & PURITY ≥95%, mixture of 5- and 6- isomers

Synonyms

FITC | Fluorescein isothiocyanate | 3',6'-Dihydroxy-5(or 6)-isothiocyanatospiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one

Storage

Protected from light,Store at -20°C

Shipped In

Ice chest + Ice pads

Descripción general

Fluorescein 5(6)-isothiocyanate, also known as FITC, is a weakly acidic hydroxyxanthene whose overall size is small, with both carboxylic acid and isothiocyanate substituents on the pendant phenyl ring. The dye has a moderately sized, nonplanar aromatic system. The isothiocyanate group reacts with nucleophilic substituents (e.g. amino, hydroxyl, thiol) of biomolecules to be attached as a fluorescent label. The maximum emission of the dye is at 519nm in the same solvent.
Application
Fluorescein 5(6)-isothiocyanate (FITC) labelled molecules are used in non-microscopic immunoassays and physiological tracing experiments. FITC is widely used in flow cytometry experiments for staining proteins, nuclei, and subnuclear particles. White blood cells (WBCs) are marked with FITC to study their response toward a chemoattractant, eventually being measured.
For fluorescent labeling of proteins (e.g. immunofluorescence); H Protein labeling for gel chromatography

Specifications

Sinónimos

FITC | Fluorescein isothiocyanate | 3', 6'-Dihydroxy-5(or 6)-isothiocyanatospiro[isobenzofuran-1(3H), 9'-[9H]xanthen]-3-one

Especificaciones y pureza

≥95%, mixture of 5- and 6- isomers

Mecanismos bioquímicos y fisiológicos

Green fluorescent, amine-reactive label. Efficiently labels antibodies and other purified proteins at primary amines (lysine side chains). Used in applications including fluorescence microscopy, flow cytometry western blotting and ELISA.

Condiciones de almacenamiento de almacenamiento

Protected from light, Store at -20°C

Enviado en

Ice chest + Ice pads

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Nota

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Pureza

≥95%

Nombres e identificadores

• WGK Alemania: 3
• Peso molecular: 389.38
• Beilstein: 1407295
• Reaxy-Rn: 1407295

Propiedades químicas y físicas

• Solubilidad: Soluble in DMSO (5 mg/ml), 2-methoxyethanol(9 mg/ml), acetone(1 mg/ml) and ethanol (20 mg/ml). It is soluble in water at less than 0.1 mg/ml.
• Sensibilidad: heat & light sensitive

Referencias

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62. Xin Tan, Renwang Sheng, Weikun Li, Yinghua Tao, Zonghao Liu, Ning Yang, Syeda Safia Hashmi, Feiling Feng, Fangzhou Liu, Liqin Ge.  (2025)  Mannose-Glycated Metal-Phenolic Microcapsules Orchestrate Phenotype Switch of Macrophages for Boosting Tumor Immunotherapy.  Advanced Science,      [PMID:40014038] [10.1002/advs.202415565]

63. Wenrun Li, Li Shen, Shiyan Fu, Yong Li, Feng Huang, Qi Li, Qinyang Lin, Hongjia Liu, Qiuchi Wang, Liyi Chen, Huanhuan Tan, Juan Li, Yazhen Zhao, Yonghong Ran, Yuhui Hao.  (2024)  Mitochondrial-Targeting Mesoporous Polydopamine Nanoparticles for Reducing Kidney Injury Caused by Depleted Uranium.  Advanced Healthcare Materials,      [PMID:39543790] [10.1002/adhm.202403015]

64. Fanqi Kong, Hongyue Yu, Lifei Gao, Enyun Xing, Yan Yu, Xiaofei Sun, Wenxing Wang, Dongyuan Zhao, Xiaomin Li.  (2024)  Multifunctional Hierarchical Nanoplatform with Anisotropic Bimodal Mesopores for Effective Neural Circuit Reconstruction after Spinal Cord Injury.  ACS Nano,      [PMID:38717602] [10.1021/acsnano.4c03252]

65. Zhongyang Ren, Xianglan Huang, Yongqiang Zhao, Linfan Shi, Shen Yang, Ritian Jin, Rong Lin, Shuji Liu, Zhiyu Liu, Yucang Zhang, Wuyin Weng.  (2024)  Novel Pickering emulsions using polysaccharide-myosin complexes: Effect of polysaccharide types.  FOOD HYDROCOLLOIDS,      [PMID:] [10.1016/j.foodhyd.2024.110469]

66. Huajing Zeng, Ziyan Chen, Pengyu Wei, Haofei Huang, Bin Liu, Zengjie Fan.  (2024)  Rapid Customization of Biomimetic Cartilage Scaffold with Stem Cell Capturing and Homing Capabilities for In Situ Inductive Regeneration of Osteochondral Defects.  ADVANCED FUNCTIONAL MATERIALS,      [PMID:] [10.1002/adfm.202400608]

67. Chuntao Zhu, Meng Yu, Zijian Liang, Lanhe Zhang, Jian Zhang.  (2024)  Selective separation of dyes and tetracycline hydrochloride in polymer-nucleotide coacervate droplets.  JOURNAL OF APPLIED POLYMER SCIENCE,  142  (5): (e56430).  [PMID:] [10.1002/app.56430]

68. Wanling Chen, Nanxi Xiang, Jiahong Huang, Huixian Xu, Zhenyuan Wang, Bo Ruan, Jichuan Zhang, Chengyu Wu, Jiaheng Zhang, YanZhen Liang.  (2024)  Supramolecular collagen nanoparticles for anti-wrinkle, skin whitening, and moisturizing effects.  COLLOIDS AND SURFACES B-BIOINTERFACES,      [PMID:39383579] [10.1016/j.colsurfb.2024.114275]

69. Jingjing Fang, Xuezhen Chen, Qiong Xiao, Yonghui Zhang, Huifen Weng, Jun Chen, Qiuming Yang, Fuquan Chen, Anfeng Xiao.  (2025)  Structure transition and gel melioration of ι-carrageenan and non-gelling senna tora gum mixed gel.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,      [PMID:40633863] [10.1016/j.ijbiomac.2025.145790]

70. Yu Zhao, Huangmei Zhou, Longliang Qiao, Jinming Xu, Rodolphe Antoine, Lunhua Deng, Sanjun Zhang, Haifeng Ye.  (2025)  Tumor-targeted ratiometric fluorescent gold nanoclusters for monitoring apoptosis and quantifying pH in vivo.  SENSORS AND ACTUATORS B-CHEMICAL,      [PMID:] [10.1016/j.snb.2025.138357]

71. Yu-Lin Zhong, Bing-Bing Wang, Kai-Fei Chu, Ai-Jun Wang, Tiejun Zhao, Jiu-Ju Feng.  (2025)  High-entropy intermetallic alloy/carbon nanoflower cascade nanozyme for multi-modal synergistic cancer therapy.  JOURNAL OF COLLOID AND INTERFACE SCIENCE,      [PMID:40845442] [10.1016/j.jcis.2025.138753]

72. Chang’e Wang, Junjian Miao, Chang Liu, Yi Guo, Lili Zhang, Ying Lu.  (2025)  Adsorption kinetics between tetrodotoxin and peptidoglycan derived from lactic acid bacteria.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,      [PMID:40769350] [10.1016/j.ijbiomac.2025.146586]

73. Wenbo Miao, David Julian McClements, Junqing Han, Hangyan Ji, Zhengyu Jin, Chao Qiu.  (2025)  Enhancement of rheological properties and oxidative stability of OSA starch oleogels by chitosan-EGCG conjugates: Influence of chitosan viscosity.  FOOD HYDROCOLLOIDS,      [PMID:] [10.1016/j.foodhyd.2025.112027]

74. Ning Yu, Shule Zhang, Rui Fang, Yingxin Zhang, Xi Xu, Lijuan Cao, Jianfa Zhang.  (2025)  Selective thrombolysis through fibrin network destabilization: An unrecognized heparin analog mechanism.  PHARMACOLOGICAL RESEARCH,      [PMID:40976458] [10.1016/j.phrs.2025.107961]

75. Ruixue Liu, Min Gao, Li Zhang, Shihan Wang, Ying Yang, Jing Bai, Ruohan Wang, Yongsheng Wang, Zhihan Wang.  (2025)  Gallic acid-reinforced Rana chensinensis ovum protein isolates-Gellan gum thermally reversible emulsion gel: Insight of the structure and potential applications in dysphagia management.  FOOD RESEARCH INTERNATIONAL,      [PMID:41185331] [10.1016/j.foodres.2025.117583]

76. Lu Zhengnan, Wang Yi, Zhang Peng, Sheng Yang, Sun Yixin, Bradley Mark, Zhang Rong.  (2025)  Design and in vitro photodynamic evaluation of self-illuminating nanospheres loaded with polyurethane containing protoporphyrin IX for anticancer and antibacterial applications.  JOURNAL OF MATERIALS SCIENCE,      [PMID:] [10.1007/s10853-025-11465-6]

77. Chunling Nie, Pengrui Wu, Yefan Niu, Zhihong Song, Xindi Wei, Zhonghui Shen, Yijun Liu, Jianguo Wang.  (2025)  Novel food-grade water-in-water Pickering emulsions stabilized by cellulose nanocrystals with long-term stability and slowing down starch digestibility.  FOOD HYDROCOLLOIDS,      [PMID:] [10.1016/j.foodhyd.2025.111507]

78. Zheng Wang, Feng Xu, Di Wu, Wei Huang, Zhiqin Chu, Yuan Lin.  (2025)  Nuclear Deformation and Stiffness-Dependent Traction Force Generation Dictate the Migration of Cells under Confinement.  ACS Applied Materials & Interfaces,      [PMID:40230252] [10.1021/acsami.5c03048]

79. Haifeng Mai, Xinqi Liang, Baoyi Zhang, Weijuan Huang.  (2025)  One-step preparation of emulsion gels stabilized by carboxymethyl chitosan and cinnamaldehyde.  FOOD HYDROCOLLOIDS,      [PMID:] [10.1016/j.foodhyd.2025.111547]

80. Jin-Long Tian, Nuo Wang, Qin-Fu Zhao, Zhi-Huan Zang, Zhi-Ying Li, Zhen-Yu Wang, Ying Zhou, Bao-Ru Yang, Sergey S. Makarov, Anton I. Chudetsky, Liang Wang, Ying He, Bin Li.  (2025)  Design of a sustained-release nanosystem for ultra-efficient absorption of anthocyanins and regulating lung damage through the “lung-gut” axis.  Journal of Advanced Research,      [PMID:40472894] [10.1016/j.jare.2025.05.059]

81. Meiling Wang, Wei Pang, Jiaxin Zhang, Li Wang, Chenxi Wang, Zesheng Liu, Ziyan Cheng, Peng Luo, Zhixian Gao, Huanying Zhou.  (2025)  Integrated multi-channel microfluidic biosensing chip based on chain amplified enhanced fluorescence for determination of SEs.  SENSORS AND ACTUATORS B-CHEMICAL,      [PMID:] [10.1016/j.snb.2025.138149]

82. Xu Zixuan, Zhang Yumin, Jiang Minqiang, Wang Yuheng, Li Min, Li Lijie, He Gaohong, Zhang Wenjun.  (2025)  A cascade sensing platform of glucose oxidase loaded Fe-MOF functionalized via boric acid modification and defect engineering for H2O2 and glucose sensitive detection.  MICROCHIMICA ACTA,  192  (7): (1-12).  [PMID:40544183] [10.1007/s00604-025-07243-5]

83. Xu Zhilang, Wang Xinxin, Liang Huaqian, Li Xinying, Li Derong, Mu Changdao, Ge Liming, Li Defu.  (2025)  Development of cinnamon essential oil-loaded Pickering emulsions stabilized by chitosan/gelatin nanoparticles with enhanced antibacterial and antibiofilm actives.  Collagen and Leather,  7  (1): (1-18).  [PMID:] [10.1186/s42825-024-00180-8]

84. Chang’e Wang, Yi Guo, Lili Zhang, Junjian Miao, Ying Lu.  (2025)  The Role of Hydroxyl Modification of Peptidoglycan to Reduce the TTX Toxicity via Superior Absorption.  Foods,  14  (12): (2145).  [PMID:40565752] [10.3390/foods14122145]

85. Xinyu Jiang, Yongliang Ma, Feng Gao, Yali Yu.  (2025)  Design and molecular mechanisms of dual-fibril composite gels based on tiger nut protein fibril and carboxylated cellulose nanofibril: Effects of pH and composition.  FOOD HYDROCOLLOIDS,      [PMID:] [10.1016/j.foodhyd.2025.112083]

86. Han Zeng, Yiyao Li, Boyuan Liu, Chenxiao Chu, Yupeng Feng, Peifu Xiao, Haoyang Yuan, Xiaopeng Deng, Yu Zhang, Tian Yin, Haibing He, Jingxin Gou, Xing Tang.  (2025)  Balancing oral sequential absorption barriers of semaglutide-loaded nanoparticles by optimization of surface glycocholic acid density.  JOURNAL OF CONTROLLED RELEASE,      [PMID:41083011] [10.1016/j.jconrel.2025.114316]

87. Qunna Xu, Yao Pu, Jiaqi Shi, Xiaoyu Xu, Jianzhong Ma.  (2025)  Tannic acid multipoint crosslinked casein/chitosan microcapsules loaded with oregano essential oil for fruit preservation.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,      [PMID:41106742] [10.1016/j.ijbiomac.2025.148324]

88. Yao Fu, Shuwen Tan, Xiaojia Xu, Wenlong Xing, Qi He, Yi Lu, Jia Tang, Xiaoyan Liu, Yu Fang.  (2025)  pH and temperature dual-responsive Pickering emulsion stabilized by alginate-based microgel particles for encapsulation of curcumin.  Carbohydrate Polymer Technologies and Applications,      [PMID:] [10.1016/j.carpta.2025.101037]

89. Yuanqing Niu, Hengrui Chang, Jiaxin Xu.  (2025)  Regenerative treatment of zinc-based nanoenzyme incorporated injectable hydrogel with mesenchymal stem cells alleviates spinal cord injury.  JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION,      [PMID:41167984] [10.1080/09205063.2025.2574942]

90. Li Hao, Jialin Zeng, Weixian Qiu, Jinhui Wang, Xiaoshan Huang, Jiachun Wu, Zhensong Weng, Ziting Yin, Hongjun Zhou, Xinhua Zhou.  (2025)  Boron Nitride Reinforced Supramolecular Gels Nano-Assembled with Fungicides toward Soil-Borne Fungal Disease Management.  Advanced Science,      [PMID:41255213] [10.1002/advs.202515855]

91. Xiaowen Feng, Yaohua Sun, Gaoshang Wang, Guangxin Feng, Jian Guo, Zhili Wan, Jinmei Wang, Xiaoquan Yang.  (2025)  Suppression of sensory bitterness of beverages via nanoscale complex coacervation.  FOOD CHEMISTRY,      [PMID:41371024] [10.1016/j.foodchem.2025.147356]

92. Liu Yiqiong, Xu Dailin, Cheng Jianwei, Fei Zhengyue, Dong Haiqing, Li Yan, Li Yongyong, Lu Peihua.  (2025)  Self-reinforcing nanomedicine orchestrates EPR effect and neutrophil hitchhiking for spatiotemporal accumulation in solid tumors.  JOURNAL OF NANOBIOTECHNOLOGY,      [PMID:41327183] [10.1186/s12951-025-03863-4]

93. Jiawen Li, Qinbo Jiang, Meiyu Chen, Teng Li, Quancai Sun, Ye Peng, Yang Li, Yucheng Zou, Hui Zhang.  (2025)  Protein thermal denaturation and 12-hydroxystearic acid loading: Dual hydrophobic modification mechanism of the electrospun fiber aerogel-templated oleogels.  CHEMICAL ENGINEERING JOURNAL,      [PMID:] [10.1016/j.cej.2025.172239]

94. Yi Zhao, Xiufang Bi, Chunlei Ni, Ruifeng Ying, Khizar Hayat, Meigui Huang.  (2025)  Nanostructural and lipidomic alterations induced by sterilization: the unforeseen stability of ultra-high temperature (UHT)-treated yak milk fat globules.  FOOD RESEARCH INTERNATIONAL,      [PMID:41652679] [10.1016/j.foodres.2025.118262]

95. Geng Cao, Zuoqian Yang, Xiangzheng Li, Xiaoyang He, Shuang Song, Chengrong Wen.  (2026)  The combined effects of konjac glucomannan and ultrasound treatments on the interaction of gluten and surimi protein.  Food Chemistry-X,      [PMID:41623964] [10.1016/j.fochx.2026.103492]

96. Wanning Gao, Shengyuan Shi, Youcong Li, Fangyuan Liu, Yudi Cheng, Jie Zheng, Meng Qiao, Shuai Yuan, Xing Zhang.  (2026)  DNA-directed assembly of core-satellite MOF structures for spatially compartmentalized multi-enzyme cascade catalysis.  CHEMICAL ENGINEERING JOURNAL,      [PMID:] [10.1016/j.cej.2026.173137]

97. Xiaoling Xie, Sicheng Tang, Ruhui Yang, Jinyu Guo, Chaofan Jin, Hao Chen, Wenjuan Huang, Xingjie Zan.  (2026)  Size-Evolving Protein Drug Nanoparticles: A Promising Non-Invasive Strategy for Retinal Neovascularization by Overcoming Multiple Ocular Barriers.  ADVANCED FUNCTIONAL MATERIALS,      [PMID:] [10.1002/adfm.202523513]

98. Chen Yue, Chen Qinyi, Ma Yuanyuan, Zhang Cheng, Xu Jie, Li Kejing, Sun Yajie, Su Xinge, Wei Mingguang, Bao Rui, Ding Tong, Tang Longguang, Yu Wenying, Ju Shenghong, Fan Wenpei.  (2026)  In situ self-assembled cell reservoir hydrogel for maneuvering multistage radioimmunotherapy.  Nature Communications,      [PMID:41565700] [10.1038/s41467-026-68490-5]

99. Ce Li, Yichao Yuan, Yaqing Bao, Yeling Ni, Nan Chen, Jigang Piao, Lu Wang, Zhihong Zhu.  (2026)  Synergistic regulation of TGF-β1/Smad2/3 signaling and inflammatory pathways via SA/NAC-based nanoplatforms: a novel strategy to enhance anti-fibrotic therapeutic outcomes in idiopathic pulmonary fibrosis.  JOURNAL OF NANOBIOTECHNOLOGY,      [PMID:41582130] [10.1186/s12951-026-04071-4]

100. Luo Wen, Gao Yanfeng, Feng Shujun, He Bangshun, Li Jingjing, Yang Jingjing, Yin Yi, Wang Meng, Xue Bin, Cao Yi, Hu Tony Y., Song Yujun.  (2026)  A Mechanophenotyping chip for high-throughput detection of metastatic bacteria-infected circulating tumor cells.  Nature Communications,  17  (1): (1412).  [PMID:41507183] [10.1038/s41467-025-68152-y]

101. Ruoxi Nie, Somia Yassin Hussain Abdalkarim, Bunan Wu, Haibin Ji, Chaopei Chen, Haicheng Huang, Hou-Yong Yu.  (2026)  Enzyme-programmed cellulose nanocrystal interfaces: Regulating degradation microenvironment and plant growth of polylactic acid films.  JOURNAL OF HAZARDOUS MATERIALS,      [PMID:] [10.1016/j.jhazmat.2026.141695]