FNDR-20123 - ≥98% , CAS No.F658744

CAS: F658744 Cat. No.: F658744 Peso molecular: 413.9

GRADE & PURITY ≥98%

Storage

Store at 2-8°C,Desiccated

Shipped In

Wet ice

Descripción general

FNDR-20123 is a safe, first-in-class, and orally active anti-malarial HDAC inhibitor with IC 50 s of 31 nM and 3 nM for Plasmodium and human HDAC , respectively. FNDR-20123 exerts anti-malarial activity against Plasmodium falciparum asexual stage (IC 50 =

Appearance:Solid

IC50& Target:human HDAC 3 nM (IC 50 ) Plasmodium HDAC 31 nM (IC 50 ) HDAC1 25 nM (IC 50 ) HDAC2 29 nM (IC 50 ) HDAC3 2 nM (IC 50 ) HDAC6 11 nM (IC 50 ) HDAC8 282 nM (IC 50 ) Plasmodium

In Vitro:FNDR-20123 is active against all resistant strains tested so far, which will be highly valuable in eliminating the rapidly evolving drug-resistant parasite. MCE has not independently confirmed the accuracy of these methods. They are for reference onl

In Vivo:FNDR-20123 (10-50mg/kg; p.o.; bw for 4 days) is also able to reduce parasitaemia significantly in a mouse model for P. falciparum infection. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model

Biological Activity:FNDR-20123 is a safe, first-in-class, and orally active anti-malarial HDAC inhibitor with IC 50 s of 31 nM and 3 nM for Plasmodium and human HDAC , respectively. FNDR-20123 exerts anti-malarial activity against Plasmodium falciparum asexual stage (IC 50 =

Specifications

Especificaciones y pureza

≥98%

Condiciones de almacenamiento de almacenamiento

Store at 2-8°C, Desiccated

Enviado en

Wet ice

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Tipo de acción

INHIBITOR

Pureza

≥98%

Nombres e identificadores

• Peso molecular: 413.9

Propiedades químicas y físicas

• Solubilidad: DMSO : 31.25 mg/mL (75.50 mM; Need ultrasonic)