Information
Foscarnet Sodium Foscarnet Sodium (Phosphonoformate) inhibits viral RNA polymerases, reverse transcriptase, and DNA polymerases through noncompetitive inhibition with dNTPs.
In vitro
Foscarnet Sodium is able to penetrate into cells and inhibit viral replication by inhibiting viral DNA synthesis. Foscarnet Sodium (300 μM) displays a more than 95% inhibition on HTLV-III reverse transcriptase activity in H9 cells infected with HTLV-III. Foscarnet Sodium has a low cellular toxicity, but shows an inhibition of cell proliferation at high concentrations, which is reversed after drug removal. Incubation 0.5-1 mM Foscarnet Sodium with HeLa cells or primary human lung fibroblast for 24-48 hr inhibited 50% DNA synthesis and/or cell proliferation. Foscarnet Sodium is able to bind with the heparin-binding domain of FGF2 and inhibits FGF2 induced cell proliferation. Foscarnet Sodium (25 μM) treating HUVEC cells for 48 hr reduced FGF2-induced cellular proliferation by 20%. Foscarnet Sodium (0.5-1 mM) reduced the 24h proliferation rate of CAL-62 cell, a Human thyroid anaplastic carcinoma cell line which expresses FGF2, to nearly 80%.
In vivo
Foscarnet Sodium display an efficient therapy effect on animal with virus diseases, such as cutaneous infection, herpes keratitis, genital infection, or systemic and interacerebral infection. For example, Foscarnet Sodium (100 mM) applied at initiated 48 h post inoculation with twice daily applications of 30 μL for 4 days, displays a more than 70% reduction in cumulative score after inoculation with HSV-1 strain C42. Foscarnet Sodium (20 mg/kg) given as an aerosol to mice infected with murine CMV caused a reduction of 60% in lung titers.
Cell Data
cell lines：
Concentrations：~1.5 mM
Incubation Time：48 hours
Powder Purity:≥98%
| Isómeros SMILES | C(=O)([O-])P(=O)([O-])[O-].[Na+].[Na+].[Na+] |
|---|---|
| PubChem CID | 44561 |
| Peso molecular | 191.95 |
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View spec sheet →| 1. Jiang Yingying, Tao Yali, Chen Yutong, Xue Xu, Ding Gangyi, Wang Sicheng, Liu Guodong, Li Mengmeng, Su Jiacan. (2022) Role of Phosphorus-Containing Molecules on the Formation of Nano-Sized Calcium Phosphate for Bone Therapy. Frontiers in Bioengineering and Biotechnology, [PMID:35813995] [10.3389/fbioe.2022.875531] |
| 2. Mi-Hua Liu, Xiao-Long Lin, Le-Le Xiao. (2024) Excess phosphate promotes SARS‑CoV‑2 N protein‑induced NLRP3 inflammasome activation via the SCAP‑SREBP2 signaling pathway. Molecular Medicine Reports, 29 (3): (1-12). [PMID:38275129] [10.3892/mmr.2024.13173] |
