Fosfomycin Disodium Salt - 10mM in Water , CAS No.26016-99-9

CAS: 26016-99-9 Cat. No.: F422911 Peso molecular: 182.02 Beilstein Registry Number: 4604425 Número EC: 247-409-2

GRADE & PURITY 10mM in Water

Synonyms

Fosfomycin disodium|Fosfomycin sodium|26016-99-9|Phosphonemycin|Fosfomycin disodium salt|Phosphomycin disodium salt|Veramina|Disodium phosphonomycin|Fosfomycin sodium [JAN]|Disodium (1R,2S)-(1,2-epoxypropyl)phosphonate|Disodium fosfomycin|Priomicina|Fosfo

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Descripción general

Phosphomycin, also known as Fosfomycin, is an antibiotic produced by Streptomyces fradiae. It is used to treat uncomplicated urinary tract infections and to reduce nephrotoxicity and ototoxicity of platinum-containing anti-tumor agents. It is used for susceptibility studies of Klebsiella pneumoniae and to study in vitro susceptibility testing procedures for fosfomycin tromethamine

Specifications

Sinónimos

Fosfomycin disodium | Fosfomycin sodium | 26016-99-9 | Phosphonemycin | Fosfomycin disodium salt | Phosphomycin disodium salt | Veramina | Disodium phosphonomycin | Fosfomycin sodium [JAN] | Disodium (1R, 2S)-(1, 2-epoxypropyl)phosphonate | Disodium fosfomycin | Priomicina | Fosfo

Especificaciones y pureza

10mM in Water

Mecanismos bioquímicos y fisiológicos

Antibiotic that concentrates in kidney and bladder; reduces nephrotoxicity and ototoxicity of platinum-containing anti-tumor agents. Fosfomycin is a phosphoenolpyruvate analog that irreversibly inhibits UDP-GlcNAc enolpyruvyl tranferase (MurA), an enzyme

Condiciones de almacenamiento de almacenamiento

Store at -80°C

Enviado en

Dry ice packs + Cold packs

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Nombres e identificadores

• Sonrisas canónicas: CC1C(O1)P(=O)([O-])[O-].[Na+].[Na+]
• IUPAC Name: disodium;[(2R,3S)-3-methyloxiran-2-yl]-dioxido-oxo-λ5-phosphane
• InChIKey: QZIQJIKUVJMTDG-JSTPYPERSA-L
• INCHI: 1S/C3H7O4P.2Na/c1-2-3(7-2)8(4,5)6;;/h2-3H,1H3,(H2,4,5,6);;/q;2*+1/p-2/t2-,3+;;/m0../s1
• Isómeros SMILES: C[C@H]1[C@H](O1)P(=O)([O-])[O-].[Na+].[Na+]
• CAS alternativo: 23155-02-4
• Peso molecular: 182.02
• Beilstein: 4604425
• Reaxy-Rn: 9154748
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=9154748&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic acids and derivatives
    • Clase Organic phosphonic acids and derivatives
      • Subclass Organic phosphonic acids

• Kingdom: Organic compounds
• Superclass: Organic acids and derivatives
• Clase: Organic phosphonic acids and derivatives
• Subclass: Organic phosphonic acids
• Intermediate Tree Nodes: Not available
• Direct Parent: Organic phosphonic acids
• Alternative Parents: Oxacyclic compounds Epoxides Organopnictogen compounds Organophosphorus compounds Organooxygen compounds Organic sodium salts Organic oxides Hydrocarbon derivatives
• Molecular Framework: Aliphatic heteromonocyclic compounds
• Substituents: Organophosphonic acid - Oxacycle - Organic alkali metal salt - Organoheterocyclic compound - Oxirane - Organic oxygen compound - Organopnictogen compound - Organic oxide - Hydrocarbon derivative - Organic sodium salt - Organic salt - Organophosphorus compound - Organooxygen compound - Aliphatic heteromonocyclic compound
• Descripción: This compound belongs to the class of organic compounds known as organic phosphonic acids. These are organic compounds containing phosphonic acid.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Objetivos asociados (humanos)

KDM4A Tchem Lysine-specific demethylase 4A (52245 Activities)

Discover Target: KDM4A

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Objetivos asociados (no humanos)

ampC Beta-lactamase AmpC (62480 Activities)

Discover Target: ampC

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Ralstonia solanacearum (520 Activities)

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Staphylococcus aureus (210822 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Escherichia coli (133304 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Bacillus subtilis (32866 Activities)

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Bacillus cereus (7522 Activities)

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Mecanismos de acción

Propiedades químicas y físicas

• Sensibilidad: Heat sensitive
• Rotación específica [α]: -5° (C=5,H2O)
• Peso molecular: 182.020 g/mol
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 0
• Exact Mass: 181.972 Da
• Monoisotopic Mass: 181.972 Da
• Topological Polar Surface Area: 75.700 Ų
• Heavy Atom Count: 10
• Formal Charge: 0
• Complexity: 127.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 2
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 3

XLogP3

Referencias

1. Lin Li-Bin, Jian Xiao, Qiang Zhang, Rui Han, Biao Xu, Sheng-Xiang Yang, Wen-Bo Han, Jiang-Jiang Tang, Jin-Ming Gao.  (2021)  Eremophilane Sesquiterpenoids with Antibacterial and Anti-inflammatory Activities from the Endophytic Fungus Septoria rudbeckiae.  JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,      [PMID:34605647] [10.1021/acs.jafc.1c04131]

2. Wen Jiang, Wenhao Lao, Zhe Xu, Yiping Feng, Jiuli Ruan.  (2025)  Degradation of antibiotic fosfomycin by peroxymonosulfate/ferrate and simultaneous phosphate removal with in situ formed ferric nanoparticles.  Environmental Science-Nano,      [PMID:] [10.1039/D5EN00701A]