Fosfenitoína disódica - ≥98% , Sodium channel alpha subunit blocker, CAS No.92134-98-0, Sodium channel alpha subunit blocker

CAS: 92134-98-0 Cat. No.: F335292 Peso molecular: 426.27 Número EC: 618-823-4

GRADE & PURITY ≥98%

Synonyms

Fosfenitoin sodium (USP) | ACC-9653-010 | FOSFENITOIN SODIUM [USP IMPURITY] | BCP13859 | Fosfenitoin sodium | FOSFENITOIN SODIUM (USP IMPURITY) | 5,5-diphenyl-3-[(phosphonooxy)methyl]-2,4-imidazolidinedione disodium salt | ACC 9653-010 | Fosfenitoin

Storage

Conservar a -20°C

Shipped In

Hielera + almohadillas de hielo

Descripción general

La fosfenitoína sódica es un profármaco de la fenitoína con propiedades anticonvulsivantes similares. Su principal mecanismo consiste en bloquear los canales de sodio neuronales dependientes de la frecuencia, del uso y del voltaje y, por tanto, limitar el disparo repetitivo de los potenciales de acción.

Specifications

Sinónimos

Fosfenitoin sodium (USP) | ACC-9653-010 | FOSFENITOIN SODIUM [USP IMPURITY] | BCP13859 | Fosfenitoin sodium | FOSFENITOIN SODIUM (USP IMPURITY) | 5, 5-diphenyl-3-[(phosphonooxy)methyl]-2, 4-imidazolidinedione disodium salt | ACC 9653-010 | Fosfenitoin

Especificaciones y pureza

≥98%

Condiciones de almacenamiento de almacenamiento

Conservar a -20°C

Enviado en

Hielera + almohadillas de hielo

Tipo de acción

BLOCKER

Mecanismo de acción

Sodium channel alpha subunit blocker

Pureza

≥98%

Nombres e identificadores

• Pubchem Sid: 488183393
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/488183393
• Sonrisas canónicas: C1=CC=C(C=C1)C2(C(=O)N(C(=O)N2)COP(=O)([O-])[O-])C3=CC=CC=C3.[Na+].[Na+]
• IUPAC Name: disodium;(2,5-dioxo-4,4-diphenylimidazolidin-1-yl)methyl phosphate
• InChIKey: GQPXYJNXTAFDLT-UHFFFAOYSA-L
• INCHI: 1S/C16H15N2O6P.2Na/c19-14-16(12-7-3-1-4-8-12,13-9-5-2-6-10-13)17-15(20)18(14)11-24-25(21,22)23;;/h1-10H,11H2,(H,17,20)(H2,21,22,23);;/q;2*+1/p-2
• Isómeros SMILES: C1=CC=C(C=C1)C2(C(=O)N(C(=O)N2)COP(=O)([O-])[O-])C3=CC=CC=C3.[Na+].[Na+]
• Peso molecular: 426.27
• Reaxy-Rn: 5899919
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=5899919&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Clase Azolidines
      • Subclass Imidazolidines
        • Level5 Imidazolidinones
          • Level6 Imidazolidinediones
            • Level7 Hydantoins
              • Level8 Phenylhydantoins

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Clase: Azolidines
• Subclass: Imidazolidines
• Intermediate Tree Nodes: Imidazolidinones - Imidazolidinediones - Hydantoins
• Direct Parent: Phenylhydantoins
• Alternative Parents: Diphenylmethanes Phenylimidazolidines Alpha amino acids and derivatives N-acyl ureas Alkyl phosphates Dicarboximides Azacyclic compounds Organopnictogen compounds Organonitrogen compounds Organic sodium salts Organic oxides Hydrocarbon derivatives Carbonyl compounds
• Molecular Framework: Aromatic heteromonocyclic compounds
• Substituents: Diphenylmethane - 5-phenylhydantoin - Phenylimidazolidine - Alpha-amino acid or derivatives - N-acyl urea - Ureide - Monocyclic benzene moiety - Organic phosphoric acid derivative - Phosphoric acid ester - Alkyl phosphate - Benzenoid - Dicarboximide - Urea - Carbonic acid derivative - Azacycle - Organic alkali metal salt - Carboxylic acid derivative - Organic nitrogen compound - Organonitrogen compound - Organooxygen compound - Organopnictogen compound - Organic oxygen compound - Organic oxide - Carbonyl group - Hydrocarbon derivative - Organic salt - Organic sodium salt - Aromatic heteromonocyclic compound
• Descripción: This compound belongs to the class of organic compounds known as phenylhydantoins. These are heterocyclic aromatic compounds containing an imiazolidinedione moiety substituted by a phenyl group.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Objetivos asociados (no humanos)

Rattus norvegicus (775804 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mecanismos de acción

Propiedades químicas y físicas

• Sensibilidad: Moisture sensitive.
• Índice de refracción: n20D~1.63 (Predicted)
• Punto de fusión (°C): 282-288° C
• Peso molecular: 406.240 g/mol
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 4
• Exact Mass: 406.031 Da
• Monoisotopic Mass: 406.031 Da
• Topological Polar Surface Area: 122.000 Ų
• Heavy Atom Count: 27
• Formal Charge: 0
• Complexity: 535.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 3

XLogP3