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· · COA & SDS Disponible para cada producto · Same-day shipping on in-stock items Galicaftor (ABBV-2222) - ≥98% , Cystic fibrosis transmembrane conductance regulator positive modulator, CAS No.1918143-53-9, Cystic fibrosis transmembrane conductance regulator positive modulator
Synonyms
4-((2R,4R)-4-(((1-(2,2-DIFLUORO-1,3-BENZODIOXOL-5-YL)CYCLOPROPYL)CARBONYL)AMINO)-7-(DIFLUOROMETHOXY)-3,4-DIHYDRO-2H-CHROMEN-2-YL)BENZOIC ACID | AKOS040745007 | J0IIT8QSQS | 4-[(2R,4R)-4-[1-(2,2-difluoro-2H-1,3-benzodioxol-5-yl)cyclopropaneamido]-7-(difluo
Shipped In
Ice chest + Ice pads
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Why this grade ≥98% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
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Storage & shipping Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
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Quality documents SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
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Literature proof Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Descripción general Information
Galicaftor (ABBV-2222) Galicaftor (ABBV-2222, GLPG2222) is a potent corrector of CFTR for the treatment of Cystic Fibrosis (CF).
Targets
CFTR
In vitro
ABBV-2222/GLPG2222 exhibits potent in vitro functional activity in primary patient cells harboring F508del/F508del CFTR with an EC50 <10 nM. ABBV-2222 promotes maturation of F508delCFTR, and stabilizes nucleotide binding domain 1 - membrane spanning domain interface. ABBV-2222 corrects F508delCFTR through action on membrane spanning domain 1.
Cell Research(from reference)
Cell lines：CFBE41o-F508del CFTR-HRP cells
Concentrations：0 - 20 μM
Incubation Time：18-24 h
Specifications Sinónimos
4-((2R, 4R)-4-(((1-(2, 2-DIFLUORO-1, 3-BENZODIOXOL-5-YL)CYCLOPROPYL)CARBONYL)AMINO)-7-(DIFLUOROMETHOXY)-3, 4-DIHYDRO-2H-CHROMEN-2-YL)BENZOIC ACID | AKOS040745007 | J0IIT8QSQS | 4-[(2R, 4R)-4-[1-(2, 2-difluoro-2H-1, 3-benzodioxol-5-yl)cyclopropaneamido]-7-(difluo
Especificaciones y pureza
≥98%
Mecanismos bioquímicos y fisiológicos
Galicaftor (ABBV-2222, GLPG2222) is a potent corrector of CFTR for the treatment of Cystic Fibrosis (CF).
Condiciones de almacenamiento de almacenamiento
Store at -20°C
Enviado en
Ice chest + Ice pads
Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.
Tipo de acción
POSITIVE MODULATOR
Mecanismo de acción
Cystic fibrosis transmembrane conductance regulator positive modulator
Propiedades del producto Nombres e identificadores Sonrisas canónicas C1CC1(C2=CC3=C(C=C2)OC(O3)(F)F)C(=O)NC4CC(OC5=C4C=CC(=C5)OC(F)F)C6=CC=C(C=C6)C(=O)O IUPAC Name 4-[(2R,4R)-4-[[1-(2,2-difluoro-1,3-benzodioxol-5-yl)cyclopropanecarbonyl]amino]-7-(difluoromethoxy)-3,4-dihydro-2H-chromen-2-yl]benzoic acid InChIKey QVDYQHXNAQHIKH-TZIWHRDSSA-N INCHI 1S/C28H21F4NO7/c29-26(30)37-17-6-7-18-19(13-21(38-22(18)12-17)14-1-3-15(4-2-14)24(34)35)33-25(36)27(9-10-27)16-5-8-20-23(11-16)40-28(31,32)39-20/h1-8,11-12,19,21,26H,9-10,13H2,(H,33,36)(H,34,35)/t19-,21-/m1/s1 Isómeros SMILES C1CC1(C2=CC3=C(C=C2)OC(O3)(F)F)C(=O)N[C@@H]4C[C@@H](OC5=C4C=CC(=C5)OC(F)F)C6=CC=C(C=C6)C(=O)O Peso molecular 559.46 Reaxy-Rn 57188872 Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=57188872&ln=
Documentation 📋 Safety Data Sheet (SDS) Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS → ✅ Certificate of Analysis (COA) Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA → 📊 Datasheet Quick-reference summary of product specifications and applications.
View datasheet → 🔬 Specification Sheet Full quality attributes and acceptance criteria for this grade.
View spec sheet →
Advanced Data Taxonomic Classification Kingdom Organic compounds Superclass Phenylpropanoids and polyketides Clase Flavonoids Subclass Flavans Intermediate Tree Nodes Not available Direct Parent Flavans Alternative Parents 1-benzopyrans Benzoic acids Benzodioxoles Benzoyl derivatives Alkyl aryl ethers Cyclopropanecarboxylic acids and derivatives Secondary carboxylic acid amides Oxacyclic compounds Monocarboxylic acids and derivatives Carboxylic acids Organopnictogen compounds Organonitrogen compounds Organofluorides Organic oxides Hydrocarbon derivatives Carbonyl compounds Alkyl fluorides Molecular Framework Aromatic heteropolycyclic compounds Substituents Flavan - 1-benzopyran - Benzopyran - Chromane - Benzoic acid - Benzoic acid or derivatives - Benzodioxole - Benzoyl - Alkyl aryl ether - Benzenoid - Cyclopropanecarboxylic acid or derivatives - Monocyclic benzene moiety - Secondary carboxylic acid amide - Carboxamide group - Oxacycle - Organoheterocyclic compound - Monocarboxylic acid or derivatives - Ether - Carboxylic acid - Carboxylic acid derivative - Organic nitrogen compound - Organic oxygen compound - Organopnictogen compound - Organic oxide - Hydrocarbon derivative - Organooxygen compound - Organonitrogen compound - Organofluoride - Organohalogen compound - Carbonyl group - Alkyl halide - Alkyl fluoride - Aromatic heteropolycyclic compound Descripción This compound belongs to the class of organic compounds known as flavans. These are compounds containing a flavan moiety, with a structure characterized by a 2-phenyl-3,4-dihydro-2H-1-benzopyran skeleton. External Descriptors Not available Data sources 1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.
Estructura 3D Objetivos asociados (humanos) Objetivos asociados (no humanos) Mecanismos de acción Certificados (CoA, COO, BSE/TSE y tabla de análisis) Propiedades químicas y físicas Solubilidad Solubility (25°C) In vitro DMSO: 100 mg/mL (178.74 mM); Ethanol: 100 mg/mL (178.74 mM); Water: Insoluble; Peso molecular 559.500 g/mol XLogP3 5.700 Hydrogen Bond Donor Count 2 Hydrogen Bond Acceptor Count 11 Rotatable Bond Count 7 Exact Mass 559.125 Da Monoisotopic Mass 559.125 Da Topological Polar Surface Area 103.000 Ų Heavy Atom Count 40 Formal Charge 0 Complexity 957.000 Isotope Atom Count 0 Defined Atom Stereocenter Count 2 Undefined Atom Stereocenter Count 0 Defined Bond Stereocenter Count 0 Undefined Bond Stereocenter Count 0 The total count of all stereochemical bonds 0 Covalently-Bonded Unit Count 1
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