≥99% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
GDC-0310 is a selective acyl-sulfonamide Na v 1.7 inhibitor, with an IC 50 of 0.6 nM for hNa v 1.7
In Vitro
GDC-0310 exhibits an EC 50 of 1.1 μM in vivo and a K i of 1.8 nM for Na v 1.7. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
GDC-0310 shows substantially improved Na v selectivity and ADME properties . GDC-0310 exhibits t1/2 values of 5 h, 46 h and 4.4 h in rat (5 mg/kg, iv), dog (1 mg/kg, iv) and cynomolgus monkeys (2 mg/kg, iv), respectively . MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Form:Solid
IC50& Target:hNa v 1.4 3.4 nM (IC 50 ) hNa v 1.2 38 nM (IC 50 ) hNa v 1.6 198 nM (IC 50 ) hNa v 1.1 202 nM (IC 50 ) hNa v 1.5 551 nM (IC 50 ) Na v 1.7 0.6 nM (IC 50 )
| Isómeros SMILES | C[C@@H](C1=CC(=CC(=C1)Cl)Cl)N2CCC(CC2)COC3=CC(=C(C=C3C4CC4)C(=O)NS(=O)(=O)C)F |
|---|---|
| PubChem CID | 118110531 |
| Peso molecular | 543.48 |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
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| Solubilidad | DMSO : 4 mg/mL (7.36 mM; ultrasonic and warming and heat to 60°C) |
|---|---|
| Peso molecular | 543.500 g/mol |
| XLogP3 | 5.700 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 6 |
| Rotatable Bond Count | 8 |
| Exact Mass | 542.121 Da |
| Monoisotopic Mass | 542.121 Da |
| Topological Polar Surface Area | 84.100 Ų |
| Heavy Atom Count | 35 |
| Formal Charge | 0 |
| Complexity | 822.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 1 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 0 |
| Covalently-Bonded Unit Count | 1 |
