GKA50 quarterhydrate , CAS No.G659443

CAS: G659443 Cat. No.: G659443 Peso molecular: 469.01

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Descripción general

GKA50 quarterhydrate is a potent glucokinase activator ( EC 50 =33 nM at 5 mM glucose) and stimulates insulin release from mouse islets of Langerhans. GKA50 quarterhydrate is a glucose-like activator of beta-cell metabolism in rodent and human islets and

Appearance:Solid

In Vitro:GKA50 (0.01-100 μM; 24 hours) enhances INS-1 cell proliferation with EC 50 values ranging from 1 to 2 μM. GKA50 (1.2 μM+40 μM glucose; 2-4 days) treatment reduces apoptosis induced by chronic high glucose in INS-1 cells. GKA50 activates human gl

In Vivo:GKA50 (1-30mg/kg; p.o.) gives significant glucose lowering in an oral glucose tolerance test. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: High-fat-fed obese female Zucker (fa/fa) rats

Biological Activity:GKA50 quarterhydrate is a potent glucokinase activator ( EC 50 =33 nM at 5 mM glucose) and stimulates insulin release from mouse islets of Langerhans. GKA50 quarterhydrate is a glucose-like activator of beta-cell metabolism in rodent and human islets and

Specifications

Condiciones de almacenamiento de almacenamiento

Store at -20°C

Enviado en

Ice chest + Ice pads

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Tipo de acción

ACTIVATOR

Nombres e identificadores

• Peso molecular: 469.01

Propiedades químicas y físicas

• Solubilidad: DMSO : 46 mg/mL (98.08 mM; Need ultrasonic and warming)