Determine the necessary mass, volume, or concentration for preparing a solution.
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analytical standard, Moligand™ Analytical standard,Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at 2-8°C,Argon charged Ships Wet ice Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 27 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Glycyrrhizic acid is a triterpenoid saponinl, acting as a direct HMGB1 antagonist, with anti-tumor, anti-diabetic activities.
| Sonrisas canónicas | CC1(C2CCC3(C(C2(CCC1OC4C(C(C(C(O4)C(=O)O)O)O)OC5C(C(C(C(O5)C(=O)O)O)O)O)C)C(=O)C=C6C3(CCC7(C6CC(CC7)(C)C(=O)O)C)C)C)C |
|---|---|
| IUPAC Name | (2S,3S,4S,5R,6R)-6-[(2S,3R,4S,5S,6S)-2-[[(3S,4aR,6aR,6bS,8aS,11S,12aR,14aR,14bS)-11-carboxy-4,4,6a,6b,8a,11,14b-heptamethyl-14-oxo-2,3,4a,5,6,7,8,9,10,12,12a,14a-dodecahydro-1H-picen-3-yl]oxy]-6-carboxy-4,5-dihydroxyoxan-3-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid |
| InChIKey | LPLVUJXQOOQHMX-QWBHMCJMSA-N |
| INCHI | 1S/C42H62O16/c1-37(2)21-8-11-42(7)31(20(43)16-18-19-17-39(4,36(53)54)13-12-38(19,3)14-15-41(18,42)6)40(21,5)10-9-22(37)55-35-30(26(47)25(46)29(57-35)33(51)52)58-34-27(48)23(44)24(45)28(56-34)32(49)50/h16,19,21-31,34-35,44-48H,8-15,17H2,1-7H3,(H,49,50)(H,51,52)(H,53,54)/t19-,21-,22-,23-,24-,25-,26-,27+,28-,29-,30+,31+,34-,35-,38+,39-,40-,41+,42+/m0/s1 |
| Isómeros SMILES | C[C@]12CC[C@](C[C@H]1C3=CC(=O)[C@@H]4[C@]5(CC[C@@H](C([C@@H]5CC[C@]4([C@@]3(CC2)C)C)(C)C)O[C@@H]6[C@@H]([C@H]([C@@H]([C@H](O6)C(=O)O)O)O)O[C@H]7[C@@H]([C@H]([C@@H]([C@H](O7)C(=O)O)O)O)O)C)(C)C(=O)O |
| Peso molecular | 822.93 |
| Reaxy-Rn | 24723660 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=24723660&ln= |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →Taxonomy Tree
| Kingdom | Organic compounds |
|---|---|
| Superclass | Lipids and lipid-like molecules |
| Clase | Prenol lipids |
| Subclass | Terpene glycosides |
| Intermediate Tree Nodes | Triterpene glycosides |
| Direct Parent | Triterpene saponins |
| Alternative Parents | Triterpenoids O-glucuronides Disaccharides O-glycosyl compounds Tricarboxylic acids and derivatives Beta hydroxy acids and derivatives Cyclohexenones Pyrans Oxanes Secondary alcohols Polyols Acetals Carboxylic acids Oxacyclic compounds Hydrocarbon derivatives Organic oxides |
| Molecular Framework | Aliphatic heteropolycyclic compounds |
| Substituents | Triterpene saponin - Triterpenoid - 1-o-glucuronide - O-glucuronide - Glucuronic acid or derivatives - Disaccharide - Glycosyl compound - O-glycosyl compound - Tricarboxylic acid or derivatives - Beta-hydroxy acid - Cyclohexenone - Pyran - Oxane - Hydroxy acid - Secondary alcohol - Ketone - Organoheterocyclic compound - Oxacycle - Polyol - Carboxylic acid derivative - Carboxylic acid - Acetal - Carbonyl group - Hydrocarbon derivative - Organic oxygen compound - Alcohol - Organooxygen compound - Organic oxide - Aliphatic heteropolycyclic compound |
| Descripción | This compound belongs to the class of organic compounds known as triterpene saponins. These are glycosylated derivatives of triterpene sapogenins. The sapogenin moiety backbone is usually based on the oleanane, ursane, taraxastane, bauerane, lanostane, lupeol, lupane, dammarane, cycloartane, friedelane, hopane, 9b,19-cyclo-lanostane, cycloartane, or cycloartanol skeleton. |
| External Descriptors | enone - tricarboxylic acid - glucosiduronic acid - triterpenoid saponin - pentacyclic triterpenoid |
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Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Fecha | Articulo |
|---|---|---|---|
| Certificate of Analysis | Dec 04, 2025 | G111375 | |
| Certificate of Analysis | Dec 04, 2025 | G111375 | |
| Certificate of Analysis | Jun 18, 2025 | G111375 | |
| Certificate of Analysis | Feb 28, 2025 | G111375 | |
| Certificate of Analysis | Aug 31, 2024 | G111375 | |
| Certificate of Analysis | Feb 04, 2024 | G111375 | |
| Certificate of Analysis | Feb 04, 2024 | G111375 | |
| Certificate of Analysis | Jun 13, 2023 | G111375 | |
| Certificate of Analysis | Oct 31, 2022 | G111375 | |
| Certificate of Analysis | Jul 29, 2022 | G111375 |
| Solubilidad | Soluble in alcohol, insoluble in ether |
|---|---|
| Sensibilidad | Moisture sensitive |
| Rotación específica [α] | 61 ° (C=1.5, EtOH) |
| Peso molecular | 822.900 g/mol |
| XLogP3 | 3.700 |
| Hydrogen Bond Donor Count | 8 |
| Hydrogen Bond Acceptor Count | 16 |
| Rotatable Bond Count | 7 |
| Exact Mass | 822.404 Da |
| Monoisotopic Mass | 822.404 Da |
| Topological Polar Surface Area | 267.000 Ų |
| Heavy Atom Count | 58 |
| Formal Charge | 0 |
| Complexity | 1730.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 19 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 0 |
| Covalently-Bonded Unit Count | 1 |
| 1. Yang Liu, Zhenfeng Wu, Yingchong Chen, Yongmei Guan, Huiwen Guo, Ming Yang, Pengfei Yue. (2023) Rubusoside As a Multifunctional Stabilizer for Novel Nanocrystal-Based Solid Dispersions with a High Drug Loading: A Case Study. JOURNAL OF PHARMACEUTICAL SCIENCES, [PMID:37659720] [10.1016/j.xphs.2023.08.024] |
| 2. Zongjian Sun, Mingxin Zhang, Yanjun Wei, Mengshuang Li, Xianggen Wu, Meng Xin. (2023) A simple but novel glycymicelle ophthalmic solution based on two approved drugs empagliflozin and glycyrrhizin: in vitro/in vivo experimental evaluation for the treatment of corneal alkali burns. Biomaterials Science, 11 (7): (2531-2542). [PMID:36779571] [10.1039/D2BM01957D] |
| 3. Chenxi Wang, Ruyu Yan, Xiaojing Li, Shangyuan Sang, David Julian McClements, Long Chen, Jie Long, Aiquan Jiao, Jinpeng Wang, Chao Qiu, Zhengyu Jin. (2023) Development of emulsion-based edible inks for 3D printing applications: Pickering emulsion gels. FOOD HYDROCOLLOIDS, [PMID:] [10.1016/j.foodhyd.2023.108482] |
| 4. Jun Zheng, Xianwen Song, Zhaoyu Yang, Yun Tan, Chao Yin, Jiafu Yin, Yufang Lu, Yufan Yang, Chuntai Liu, Lunzhao Yi, Yi Zhang. (2022) Self-assembling glycyrrhizic acid micellar hydrogels as encapsulant carriers for delivery of curcumin. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, [PMID:] [10.1016/j.colsurfa.2022.130680] |
| 5. Qiaoyu He, Yumeng Shi, Hong Xing, Qian Tang, Jing Liu, Chunxia Li, Han Zhang, Boli Zhang, Junhua Zhang, Xiaopeng Chen. (2022) Modulating effect of Xuanfei Baidu granule on host metabolism and gut microbiome in rats.. Frontiers in Pharmacology, [PMID:36147334] [10.3389/fphar.2022.922642] |
| 6. Yujie Zhang, Min Chen, Shouyong Zhou, Haifeng Han, Mingliang Zhang, Hongdeng Qiu. (2021) A carbonylative coupling approach to alkyl stationary phases with variable embedded carbamate groups for high-performance liquid chromatography. JOURNAL OF CHROMATOGRAPHY A, [PMID:34875517] [10.1016/j.chroma.2021.462718] |
| 7. Zhaoyan Zhao, Yuchen Xiao, Lingqing Xu, Ye Liu, Guanmin Jiang, Wei Wang, Bin Li, Tianchuan Zhu, Qingqin Tan, Lantian Tang, Haibo Zhou, Xi Huang, Hong Shan. (2021) Glycyrrhizic Acid Nanoparticles as Antiviral and Anti-inflammatory Agents for COVID-19 Treatment. ACS Applied Materials & Interfaces, [PMID:33930273] [10.1021/acsami.1c02755] |
| 8. Ting Pan, Yali Lin, Quanzhou Wu, Kaiwen Huang, Jianfeng He. (2020) Preparation of boronate-functionalized surface molecularly imprinted polymer microspheres with polydopamine coating for specific recognition and separation of glycoside template. JOURNAL OF SEPARATION SCIENCE, 44 (12): (2465-2473). [PMID:32367689] [10.1002/jssc.202000125] |
| 9. Ting Tong, Hongwei Hu, Junwei Zhou, Shuangfei Deng, Xiaotong Zhang, Wantao Tang, Liurong Fang, Shaobo Xiao, Jiangong Liang. (2020) Glycyrrhizic-Acid-Based Carbon Dots with High Antiviral Activity by Multisite Inhibition Mechanisms. Small, 16 (13): (1906206). [PMID:32077621] [10.1002/smll.201906206] |
| 10. Qiu Miao, Huang Keqing, Liu Yanzhuo, Yang Yuqing, Tang Honglin, Liu Xiaoxiao, Wang Chenlong, Chen Honglei, Xiong Yu, Zhang Jing, Yang Jing. (2019) Modulation of intestinal microbiota by glycyrrhizic acid prevents high-fat diet-enhanced pre-metastatic niche formation and metastasis. Mucosal Immunology, 12 (4): (945-957). [PMID:30755716] [10.1038/s41385-019-0144-6] |
| 11. Haixia Li, Dandan Guo, Liangran Zhang, Xiao Feng. (2018) Glycyrrhizin attenuates histamine-mediated MUC5AC upregulation, inflammatory cytokine production, and aquaporin 5 downregulation through suppressing the NF-κB pathway in human nasal epithelial cells. CHEMICO-BIOLOGICAL INTERACTIONS, [PMID:29452068] [10.1016/j.cbi.2018.02.010] |
| 12. Zhen-Huan Lv, Trinh Anh Phuong, Shi-Jie Jin, Xiao-Xue Li, Ming Xu. (2017) Protection by simvastatin on hyperglycemia-induced endothelial dysfunction through inhibiting NLRP3 inflammasomes. Oncotarget, [PMID:29207644] [10.18632/oncotarget.20443] |
| 13. Huang Run-Yue, Chu Yong-Liang, Jiang Ze-Bo, Chen Xiu-Ming, Zhang Xian, Zeng Xing. (2014) Glycyrrhizin Suppresses Lung Adenocarcinoma Cell Growth Through Inhibition of Thromboxane Synthase. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, 33 (2): (375-388). [PMID:24556579] [10.1159/000356677] |
| 14. Ruipeng Huang, Chuan Hu, Shaoqing Xu, Hongyu Chen, Junpeng Pan, Jiechao Xia, Dingqi Xie, Yang Jin, Zhijie Wang, Chengliang Zhao. (2024) 3D-Printed Bifunctional Scaffold for Treatment of Critical Bone Defects Based on Osteoimmune Microenvironment Regulation and Osteogenetic Effects. ACS Applied Materials & Interfaces, [PMID:39523994] [10.1021/acsami.4c15212] |
| 15. Yi Wang, Wanxin Liu, Ziwei Chen, Kaixin Zheng, Xianliang Yi, Jiao Wang, Xiaochen Chen, Xianhua Liu. (2025) Distinct responses of Caenorhabditis elegans to polyethylene microplastics and plant secondary metabolites. ENVIRONMENTAL POLLUTION, [PMID:40086784] [10.1016/j.envpol.2025.126051] |
| 16. Mei-yuan Li, Zhi-peng Jia, De-min Li, Man-ping Luo, Ying-ying Meng, Kang- xu Wang, Bei Wang, Bing Liu, Xin-guo Zhang, Qin Li. (2024) Enhanced co-extraction of glycyrrhizic acid and glabridin from Glycyrrhiza glabra L. through enzyme-focused techniques. INDUSTRIAL CROPS AND PRODUCTS, [PMID:] [10.1016/j.indcrop.2024.118145] |
| 17. Jiehong He, Tian Wang, Yuanyuan Xie, Xianrui Liang. (2024) Preparation and characterization of self-assembling nanoparticles in Gancao Ganjiang decoction. JOURNAL OF MOLECULAR LIQUIDS, [PMID:] [10.1016/j.molliq.2024.125174] |
| 18. Peng Deng, Qifan Wang, Shengfang Wu, Xiuwen Zhou, Fatih Oz, Qiuming Chen, Zhaojun Wang, Zhiyong He, Jie Chen, Maomao Zeng. (2025) Synergistic effect of spice extracts on multiple hazards formation and sensory markers in beef flavoring. Food Bioscience, [PMID:] [10.1016/j.fbio.2025.106099] |
| 19. Teng Wang, Zexi Zhang, Jiayu Wang, Yuanyuan Fu, Xiaolin Zou, Wei Li, Zhaolun Zhang, Youting Liu, Zhaojun Jia, Zhenguo Wen, Yong Chen. (2025) Optimization of the Chitosan-Assisted Extraction for Phillyrin and Forsythoside A from Forsythia suspensa Leaves Using Response Surface Methodology. MOLECULES, 30 (17): (3528). [PMID:40942054] [10.3390/molecules30173528] |
| 20. Xiongqin Wang, Kunhui Sun, Junlin Dong, Yanli Ge, Haifan Liu, Xingyue Jin, Xiao Pei, Ping Wang, Jianbing Jiang, Tiejie Wang, Xuelei Hu, Shuguang Yuan, Bing Wang, Xie-an Yu. (2025) Carrier-free nanoparticles based on natural products trigger dual "synergy and attenuation" for enhanced phototherapy of liver cancer. Materials Today Bio, [PMID:40984881] [10.1016/j.mtbio.2025.102278] |
| 21. Jingyi Chen, Xuan Wang, Xuemei Yuan, Haiting Zou, Jiaye Li, Guopu Chen, Qian Tan. (2025) Bioinspired Multifunctional Hydrogel Loaded with Netrin-1 for Diabetic Wound Healing. ACS Applied Materials & Interfaces, [PMID:40956250] [10.1021/acsami.5c13028] |
| 22. Qianzhu Lin, Chenxi Wang, Zhengyu Jin, Liming Jiang, Jinsheng Wen, David Julian McClements, Chao Qiu. (2024) Construction of oleogels based on emulsion gels stabilized by glycyrrhizic acid and chitosan. FOOD HYDROCOLLOIDS, [PMID:] [10.1016/j.foodhyd.2024.110163] |
| 23. Zhihuan Zheng, Ziqiang Wu, Chao Li, Lei Zhou, Weibin Hou, Wei Xiong, Shuo Tan. (2025) Enhanced immunoregulation in traumatic urethral stricture repair utilizing a glycyrrhizic acid-infused antiswelling biogel scaffold. RSC Advances, 15 (18): (14217-14226). [PMID:40322255] [10.1039/D5RA02083B] |
| 24. Fangfei Zhou, Qingge Lu, Lingyu Kong, Sitong Wang, Haixia Zhang, Meng Zhao, Yue Hu, Fanwu Wu, Chenxi Wu. (2025) Glycyrrhiza uralensis Fisch. suppresses cell migration via ROS and JAK/STAT signalling pathways in Drosophila. Frontiers in Pharmacology, [PMID:40657637] [10.3389/fphar.2025.1549920] |
| 25. Bu Xiao-fen, Li Jun, Zhu Hong. (2025) Glycyrrhizin mediates autophagy through the STAT3/survivin pathway to inhibit proliferation and angiogenesis in hepatoma cells. CYTOTECHNOLOGY, 77 (4): (1-12). [PMID:40689349] [10.1007/s10616-025-00819-2] |
| 26. Ying Liu, Linlin Yu, Le Wang, Xiaowei Fang, Tenggao Zhu, Huanwen Chen, Wenliu Zhang, Dong Wu. (2026) Changes in Components During Quality Formation and Evaluation of Honey-Processed Glycyrrhiza uralensis Fisch. from Different Geographical Origins by Sequential Electrospray Ionization Mass Spectrometry. ACS Omega, [PMID:41585634] [10.1021/acsomega.5c08675] |
| 27. Wanlei Ren, Junqi Zhao, Xujuan Lv, Sha Qiu, Yujia Ren, Xuxin Yan, Shuai Qin, Daoqing Fan, Juan Wang, Xueji Zhang. (2026) Colorimetric sensor arrays for the analysis of active ingredients in licorice based on the efficient catalysis of oxidase-like manganese-nanozymes. TALANTA, [PMID:] [10.1016/j.talanta.2026.129570] |
Our grade selection guide covers purity, stabilizer status, and application suitability for all variants in our catalog.
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