GppNHp - ≥95% , CAS No.64564-03-0

CAS: 64564-03-0 Cat. No.: G276465 Peso molecular: 545.93 PubChem CID: 135889524

GRADE & PURITY ≥95%

Synonyms

DTXSID30657541 | Tetralithium 2-amino-9-[5-O-({[(phosphonatoamino)phosphinato]oxy}phosphinato)pentofuranosyl]-3,9-dihydro-6H-purin-6-one | 5'-Guanylylimidodiphosphate Tetralithium Salt | Tetralithium;[[5-(2-amino-6-oxo-1H-purin-9-yl)-3,4-dihydroxyoxolan-2

Storage

Store at -20°C,Desiccated

Shipped In

Ice chest + Ice pads

Descripción general

Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.

Specifications

Sinónimos

DTXSID30657541 | Tetralithium 2-amino-9-[5-O-({[(phosphonatoamino)phosphinato]oxy}phosphinato)pentofuranosyl]-3, 9-dihydro-6H-purin-6-one | 5'-Guanylylimidodiphosphate Tetralithium Salt | Tetralithium;[[5-(2-amino-6-oxo-1H-purin-9-yl)-3, 4-dihydroxyoxolan-2

Especificaciones y pureza

≥95%

Mecanismos bioquímicos y fisiológicos

Non-hydrolyzable GTP analog. Has an amine group in place of an oxygen atom. Potent adenylate cyclase stimulator. Binds tightly to G-protein in the presence of Mg 2+ . Forms stable Ras complexes.

Condiciones de almacenamiento de almacenamiento

Store at -20°C, Desiccated

Enviado en

Ice chest + Ice pads

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Tipo de acción

ACTIVATOR

Nota

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Pureza

≥95%

Nombres e identificadores

• Pubchem Sid: 504773451
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504773451
• Sonrisas canónicas: [Li+].[Li+].[Li+].[Li+].C1=NC2=C(N1C3C(C(C(O3)COP(=O)([O-])OP(=O)(NP(=O)([O-])[O-])[O-])O)O)N=C(NC2=O)N
• IUPAC Name: tetralithium;[[5-(2-amino-6-oxo-1H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-oxidophosphoryl]oxy-(phosphonatoamino)phosphinate
• InChIKey: NUKFMILQQVRELO-UHFFFAOYSA-J
• INCHI: 1S/C10H17N6O13P3.4Li/c11-10-13-7-4(8(19)14-10)12-2-16(7)9-6(18)5(17)3(28-9)1-27-32(25,26)29-31(23,24)15-30(20,21)22;;;;/h2-3,5-6,9,17-18H,1H2,(H,25,26)(H3,11,13,14,19)(H4,15,20,21,22,23,24);;;;/q;4*+1/p-4
• Isómeros SMILES: [Li+].[Li+].[Li+].[Li+].C1=NC2=C(N1C3C(C(C(O3)COP(=O)([O-])OP(=O)(NP(=O)([O-])[O-])[O-])O)O)N=C(NC2=O)N
• PubChem CID: 135889524
• Peso molecular: 545.93

Propiedades químicas y físicas

• Solubilidad: Soluble in water to 75 mM

Referencias

1. Liu Chuqi, Liu Dexiang, Zheng Xiang, Guan Jiali, Zhou Xinyan, Zhang Haikun, Wang Shen, Li Qiubai, Lu Gan, He Jun, Ma Cong.  (2025)  Munc13-4 mediates tumor immune evasion by regulating the sorting and secretion of PD-L1 via exosomes.  Nature Communications,  16  (1): (1-24).  [PMID:41083534] [10.1038/s41467-025-64149-9]