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· · COA & SDS Disponible para cada producto · Same-day shipping on in-stock items GSK 2837808A - ≥98%(HPLC) , CAS No.1445879-21-9
Synonyms
3-[[3-[(Cyclopropylamino)sulfonyl]-7-(2,4-dimethoxy-5-pyrimidinyl)-4-quinolinyl]amino]-5-(3,5-difluorophenoxy)benzoic acid
Storage
Protected from light,Store at -20°C,Argon charged
Shipped In
Ice chest + Ice pads
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Why this grade ≥98%(HPLC) for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
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Storage & shipping Protected from light,Store at -20°C,Argon charged Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
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Quality documents SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
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Literature proof Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Descripción general Product description
GSK2837808A is a potent and selective lactate dehydrogenase A (LDHA) inhibitor with IC50s of 2.6 and 43 nM for hLDHA and hLDHB, respectively.
Specifications Sinónimos
3-[[3-[(Cyclopropylamino)sulfonyl]-7-(2, 4-dimethoxy-5-pyrimidinyl)-4-quinolinyl]amino]-5-(3, 5-difluorophenoxy)benzoic acid
Especificaciones y pureza
≥98%(HPLC)
Mecanismos bioquímicos y fisiológicos
Potent and selective lactate dehydrogenase A and B (LDHA and LDHB) inhibitor (IC50values are 2.6 and 43 nM for LDHA and LDHB respectively). Inhibits lactate production in selected cancer cell lines. Reduces glucose uptake and enhances mitochondrial oxygen
Condiciones de almacenamiento de almacenamiento
Protected from light, Store at -20°C, Argon charged
Enviado en
Ice chest + Ice pads
Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.
Nombres e identificadores Pubchem Sid 488202259 Pubchem Sid Url https://pubchem.ncbi.nlm.nih.gov/substance/488202259 Sonrisas canónicas COC1=NC(=NC=C1C2=CC3=NC=C(C(=C3C=C2)NC4=CC(=CC(=C4)C(=O)O)OC5=CC(=CC(=C5)F)F)S(=O)(=O)NC6CC6)OC IUPAC Name 3-[[3-(cyclopropylsulfamoyl)-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl]amino]-5-(3,5-difluorophenoxy)benzoic acid InChIKey RZBCPMYJIARMGV-UHFFFAOYSA-N INCHI 1S/C31H25F2N5O7S/c1-43-29-25(14-35-31(37-29)44-2)16-3-6-24-26(9-16)34-15-27(46(41,42)38-20-4-5-20)28(24)36-21-7-17(30(39)40)8-22(13-21)45-23-11-18(32)10-19(33)12-23/h3,6-15,20,38H,4-5H2,1-2H3,(H,34,36)(H,39,40) Isómeros SMILES COC1=NC(=NC=C1C2=CC3=NC=C(C(=C3C=C2)NC4=CC(=CC(=C4)C(=O)O)OC5=CC(=CC(=C5)F)F)S(=O)(=O)NC6CC6)OC Peso molecular 649.62 Reaxy-Rn 23754927 Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=23754927&ln=
Documentation 📋 Safety Data Sheet (SDS) Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS → ✅ Certificate of Analysis (COA) Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA → 📊 Datasheet Quick-reference summary of product specifications and applications.
View datasheet → 🔬 Specification Sheet Full quality attributes and acceptance criteria for this grade.
View spec sheet →
Advanced Data Taxonomic Classification Kingdom Organic compounds Superclass Organoheterocyclic compounds Clase Quinolines and derivatives Subclass Quinoline-3-sulfonamides Intermediate Tree Nodes Not available Direct Parent Quinoline-3-sulfonamides Alternative Parents Diphenylethers Phenylpyrimidines 4-aminoquinolines Diarylethers Pyridinesulfonamides Aminobenzoic acids Benzoic acids Aniline and substituted anilines Phenoxy compounds Benzoyl derivatives Phenol ethers Fluorobenzenes Alkyl aryl ethers Aminopyridines and derivatives Organosulfonamides Primary aromatic amines Aryl fluorides Aminosulfonyl compounds Heteroaromatic compounds Amino acids Carboxylic acids Azacyclic compounds Secondary amines Hydrocarbon derivatives Organic oxides Organofluorides Molecular Framework Aromatic heteropolycyclic compounds Substituents Quinoline-3-sulfonamide - Diphenylether - 5-phenylpyrimidine - Aminoquinoline - 4-aminoquinoline - Diaryl ether - Aminobenzoic acid - Aminobenzoic acid or derivatives - Pyridine-3-sulfonamide - Benzoic acid or derivatives - Benzoic acid - Phenoxy compound - Benzoyl - Phenol ether - Aniline or substituted anilines - Fluorobenzene - Halobenzene - Aminopyridine - Alkyl aryl ether - Organosulfonic acid amide - Monocyclic benzene moiety - Aryl halide - Aryl fluoride - Benzenoid - Pyrimidine - Pyridine - Primary aromatic amine - Heteroaromatic compound - Organic sulfonic acid or derivatives - Organosulfonic acid or derivatives - Aminosulfonyl compound - Sulfonyl - Amino acid or derivatives - Amino acid - Carboxylic acid - Carboxylic acid derivative - Secondary amine - Azacycle - Ether - Amine - Organic oxide - Organohalogen compound - Organofluoride - Organonitrogen compound - Organic oxygen compound - Organooxygen compound - Organosulfur compound - Organic nitrogen compound - Hydrocarbon derivative - Aromatic heteropolycyclic compound Descripción This compound belongs to the class of organic compounds known as quinoline-3-sulfonamides. These are quinolines in which the quinoline ring system is substituted by one sulfonamide group at the 3-position. External Descriptors Not available Data sources 1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.
Estructura 3D Objetivos asociados (humanos) Objetivos asociados (no humanos) Mecanismos de acción Certificados (CoA, COO, BSE/TSE y tabla de análisis) Propiedades químicas y físicas Solubilidad Solvent:DMSO, Max Conc. mg/mL: 64.96, Max Conc. mM: 100 Sensibilidad light sensitive Peso molecular 649.600 g/mol XLogP3 5.600 Hydrogen Bond Donor Count 3 Hydrogen Bond Acceptor Count 14 Rotatable Bond Count 11 Exact Mass 649.144 Da Monoisotopic Mass 649.144 Da Topological Polar Surface Area 170.000 Ų Heavy Atom Count 46 Formal Charge 0 Complexity 1140.000 Isotope Atom Count 0 Defined Atom Stereocenter Count 0 Undefined Atom Stereocenter Count 0 Defined Bond Stereocenter Count 0 Undefined Bond Stereocenter Count 0 The total count of all stereochemical bonds 0 Covalently-Bonded Unit Count 1
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