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GSK256066 - Moligand™, ≥98% , Phosphodiesterase 4 inhibitor, CAS No.801312-28-7, Phosphodiesterase 4 inhibitor

CAS: 801312-28-7 Cat. No.: G127379 Peso molecular: 518.58 Número EC: 629-882-0
COA
GSK256066 - Moligand™, ≥98% CAS No(801312-28-7) by Aladdin Scientific
Disponible para pedir
GRADE & PURITY Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
Synonyms
DTXSID30230090 | AC-32928 | Histidine-Alanine dipeptide | MFCD18206923 | MLS006011116 | 6-[3-(Dimethylcarbamoyl)phenyl]sulfonyl-4-(3-methoxyanilino)-8-methylquinoline-3-carboxamide | SMR004702897 | NCGC00346620-06 | C27H26N4O5S | NCGC00346620-08 | SCHEMBL
Storage
Protected from light,Store at -20°C
Shipped In
Ice chest + Ice pads
★
 ·  off list, applied to all prices below.
Size
Estado
Price
Qty
1mg
G127379-1mg
5

44,90US$

67,90US$
Guardar 23,00 US$ (33.87%)
5mg
G127379-5mg
3

167,90US$

251,90US$
Guardar 84,00 US$ (33.35%)
25mg
G127379-25mg
1

629,90US$

944,90US$
Guardar 315,00 US$ (33.34%)
Enter a quantity for the sizes you want to add.
Bulk / Custom
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SDS
Safety data
COA
Certificate
DS
Datasheet
SP
Spec sheet
Descripción general Specifications Nombres e identificadores Documentation Advanced Data Taxonomic Classification Estructura 3D Objetivos asociados (humanos) Objetivos asociados (no humanos) Mecanismos de acción Certificados (CoA, COO, BSE/TSE y tabla de análisis) Propiedades químicas y físicas Calculadoras de soluciones Reseñas
🧪

Why this grade

Moligand™, ≥98% Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

🌡

Storage & shipping

Protected from light,Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.

📋

Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

📚

Literature proof

Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Descripción general

GSK256066 is a selective PDE4B(equal affinity to isoforms A-D) inhibitor with IC50 of 3.2 pM, >380,000-fold selectivity versus PDE1/2/3/5/6 and >2500-fold selectivity against PDE4B versus PDE7
A highly potent and selective inhibitor of phosphodiesterase 4

Specifications

Sinónimos
DTXSID30230090 | AC-32928 | Histidine-Alanine dipeptide | MFCD18206923 | MLS006011116 | 6-[3-(Dimethylcarbamoyl)phenyl]sulfonyl-4-(3-methoxyanilino)-8-methylquinoline-3-carboxamide | SMR004702897 | NCGC00346620-06 | C27H26N4O5S | NCGC00346620-08 | SCHEMBL
Especificaciones y pureza
Moligand™, ≥98%
Mecanismos bioquímicos y fisiológicos
GSK256066 is a slow and tight binding inhibitor of PDE4B with apparent IC50 of 3.2 pM. GSK256066 is an extremely potent inhibitor of LPS-stimulated TNFα production in PBMCs with pIC50 of 11.0 and IC50 of 10 pM and human whole-blood cultures with pIC50 of
Condiciones de almacenamiento de almacenamiento
Protected from light, Store at -20°C
Enviado en
Ice chest + Ice pads
Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.
Grado
Moligand™
Tipo de acción
INHIBITOR
Mecanismo de acción
Phosphodiesterase 4 inhibitor
Pureza
≥98%
Nombres e identificadores
Sonrisas canónicasCC1=CC(=CC2=C(C(=CN=C12)C(=O)N)NC3=CC(=CC=C3)OC)S(=O)(=O)C4=CC=CC(=C4)C(=O)N(C)C
IUPAC Name6-[3-(dimethylcarbamoyl)phenyl]sulfonyl-4-(3-methoxyanilino)-8-methylquinoline-3-carboxamide
InChIKeyJFHROPTYMMSOLG-UHFFFAOYSA-N
INCHI1S/C27H26N4O5S/c1-16-11-21(37(34,35)20-10-5-7-17(12-20)27(33)31(2)3)14-22-24(16)29-15-23(26(28)32)25(22)30-18-8-6-9-19(13-18)36-4/h5-15H,1-4H3,(H2,28,32)(H,29,30)
Isómeros SMILES CC1=CC(=CC2=C(C(=CN=C12)C(=O)N)NC3=CC(=CC=C3)OC)S(=O)(=O)C4=CC=CC(=C4)C(=O)N(C)C
Peso molecular 518.58
Reaxy-Rn 12158339
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=12158339&ln=

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

KingdomOrganic compounds
SuperclassOrganoheterocyclic compounds
ClaseQuinolines and derivatives
SubclassQuinoline carboxamides
Intermediate Tree Nodes Not available
Direct ParentQuinoline-3-carboxamides
Alternative Parents 4-aminoquinolines  Aminophenyl ethers  Pyridinecarboxylic acids and derivatives  Benzamides  Benzenesulfonyl compounds  Methoxyanilines  Anisoles  Phenoxy compounds  Methoxybenzenes  Benzoyl derivatives  Alkyl aryl ethers  Aminopyridines and derivatives  Primary aromatic amines  Vinylogous amides  Sulfones  Tertiary carboxylic acid amides  Heteroaromatic compounds  Primary carboxylic acid amides  Amino acids and derivatives  Azacyclic compounds  Secondary amines  Hydrocarbon derivatives  Organic oxides  
Molecular FrameworkAromatic heteropolycyclic compounds
Substituents Quinoline-3-carboxamide - Aminoquinoline - 4-aminoquinoline - Pyridine carboxylic acid or derivatives - Methoxyaniline - Benzoic acid or derivatives - Benzamide - Benzenesulfonyl group - Aminophenyl ether - Benzoyl - Aniline or substituted anilines - Anisole - Phenol ether - Phenoxy compound - Methoxybenzene - Alkyl aryl ether - Aminopyridine - Monocyclic benzene moiety - Benzenoid - Primary aromatic amine - Pyridine - Tertiary carboxylic acid amide - Sulfonyl - Sulfone - Heteroaromatic compound - Vinylogous amide - Primary carboxylic acid amide - Amino acid or derivatives - Carboxamide group - Secondary amine - Ether - Carboxylic acid derivative - Azacycle - Amine - Organic nitrogen compound - Organonitrogen compound - Hydrocarbon derivative - Organic oxide - Organic oxygen compound - Organooxygen compound - Organosulfur compound - Aromatic heteropolycyclic compound
DescripciónThis compound belongs to the class of organic compounds known as quinoline-3-carboxamides. These are quinolines in which the quinoline ring system is substituted by one carboxamide group at the 3-position.
External Descriptors Not available
Estructura 3D
Modelo de Estructura Química Interactiva





Objetivos asociados (humanos)
PDE4B Tclin Phosphodiesterase 4B (2748 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Homo sapiens (32628 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PBMC (10003 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PDE4A Tclin Phosphodiesterase 4 (3344 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Objetivos asociados (no humanos)
Hdac6 Histone deacetylase 6 (222 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Rattus norvegicus (775804 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Blood (6 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Plasma (328 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Lung (9 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Liver microsome (341 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Whole blood (71 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mecanismos de acción
Certificados (CoA, COO, BSE/TSE y tabla de análisis)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

2 results found

Lot NumberCertificate TypeFechaArticulo
H2526417Certificate of AnalysisMay 19, 2025 G127379
H2526428Certificate of AnalysisMay 19, 2025 G127379
Propiedades químicas y físicas
SolubilidadSolubility：DMSO
SensibilidadLight sensitive
Peso molecular518.600 g/mol
XLogP33.800
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count7
Rotatable Bond Count7
Exact Mass518.162 Da
Monoisotopic Mass518.162 Da
Topological Polar Surface Area140.000 Ų
Heavy Atom Count37
Formal Charge0
Complexity922.000
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
The total count of all stereochemical bonds0
Covalently-Bonded Unit Count1
Calculadoras de soluciones
Reseñas

Reseñas de cliente

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