≥98% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Information
GSK2879552 2HCl GSK2879552 2HCl is a potent, selective, orally bioavailable, irreversible LSD1 inhibitor with K i app of 1.7 μM. Phase 1.
Targets
LSD1 (Cell-free assay) 1.7 μM(Ki)
In vitro
In 165 cell lines, GSK2879552 inhibits the growth of 9/28 small cell lung carcinoma (SCLC) lines and 20/29 AML lines ranged from 40% to 100%. The subset of SCLC lines and primary samples that undergo growth inhibition in response to GSK2879552 exhibit DNA hypomethylation of a signature set of probes.
In vivo
In SCLC xenograft bearing mice, GSK2879552 (1.5 mg/kg, p.o.) demonstrates tumor growth inhibition by 17%-83%.
Cell Research(from reference)
Cell lines：165 human cancer cell lines
Concentrations：~10 μM
Incubation Time：6 d
| ALogP | 1.586 |
|---|---|
| Recuento HBD | 1 |
| Enlace rotable | 7 |
| Pubchem Sid | 504773715 |
|---|---|
| Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/504773715 |
| Sonrisas canónicas | C1CN(CCC1CN[C]2C[C]2C3=CC=CC=C3)CC4=CC=C(C=C4)C(=O)O.Cl.Cl |
| InChIKey | ORIKOCSQHYGXAV-UHFFFAOYSA-N |
| INCHI | 1S/C23H26N2O2.2ClH/c26-23(27)20-8-6-18(7-9-20)16-25-12-10-17(11-13-25)15-24-22-14-21(22)19-4-2-1-3-5-19;;/h1-9,17,24H,10-16H2,(H,26,27);2*1H |
| PubChem CID | 156588618 |
| Peso molecular | 437.4 |
Comprehensive hazard, handling, storage, and regulatory compliance document.
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| Lot Number | Certificate Type | Fecha | Articulo |
|---|---|---|---|
 K2219604 | Certificate of Analysis | Sep 04, 2025 | G413833 |
| K2219605 | Certificate of Analysis | Sep 04, 2025 | G413833 |
| K2219612 | Certificate of Analysis | Sep 04, 2025 | G413833 |
| K2219614 | Certificate of Analysis | Sep 04, 2025 | G413833 |
| K2219658 | Certificate of Analysis | Sep 04, 2025 | G413833 |
| L2417131 | Certificate of Analysis | Sep 21, 2022 | G413833 |
| L2420359 | Certificate of Analysis | Sep 21, 2022 | G413833 |
| Solubilidad | Solubility (25°C) In vitro Water: 44 mg/mL (100.59 mM); DMSO: 29 mg/mL (66.3 mM); Ethanol: Insoluble; |
|---|---|
| Sensibilidad | Moisture sensitive |
| DMSO (mg/ml) Solubilidad máxima | 29 |
| DMSO (mM) Solubilidad máxima | 66.30086877 |
| Agua (mg/ml) Solubilidad máxima | 44 |
| Agua (mM) Solubilidad máxima | 100.5944216 |
