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GSK2945 hydrochloride - ≥99% , CAS No.G659004
Disponible para pedir
GRADE & PURITY ≥99%
Storage
Store at 2-8°C,Argon charged
Shipped In
Wet ice
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Why this grade
≥99% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Storage & shipping
Store at 2-8°C,Argon charged Ships Wet ice Check lot-specific COA for exact specifications.
Quality documents
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Literature proof
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Descripción general
GSK2945 hydrochloride is a class of tertiary amine, and is a highly specific Rev-erbα / REV-ERBα (mouse/human reverse erythroblastosis virus α) antagonist with EC 50 s of 21.5 μM and 20.8 μM, respectively. GSK2945 hydrochloride enhances cholesterol 7α-hyd
Appearance:Solid
In Vitro:GSK2945 dose-dependently enhances the transcriptional activity of Rev-erbα and a Bmal1 (a target gene of REV-ERBs) luciferase reporter ( EC 50 of 2.05 μM). GSK2945 (20 μM; 12 hours and 24 hours; mouse and human primary hepatocytes) treatment incre
In Vivo:GSK2945 (0-10mg/kg; intraperitoneal injection; twice every day; for 7 days; male C57BL/6 mice) treatment increases hepatic mouse cholesterol 7α-hydroxylase (Cyp7a1) level and lowers plasma cholesterol in wild-type mice. MCE has not independently con
Biological Activity:GSK2945 hydrochloride is a class of tertiary amine, and is a highly specific Rev-erbα / REV-ERBα (mouse/human reverse erythroblastosis virus α) antagonist with EC 50 s of 21.5 μM and 20.8 μM, respectively. GSK2945 hydrochloride enhances cholesterol 7α-hyd
Specifications
Especificaciones y pureza
≥99%
Condiciones de almacenamiento de almacenamiento
Store at 2-8°C, Argon charged
Enviado en
Wet ice
Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.
Tipo de acción
ACTIVATOR
Pureza
≥99%
Nombres e identificadores
| Peso molecular | 457.8 |
|---|
Documentation
📋 Safety Data Sheet (SDS)
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →✅ Certificate of Analysis (COA)
Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →🔬 Specification Sheet
Full quality attributes and acceptance criteria for this grade.
View spec sheet →Advanced Data
Certificados (CoA, COO, BSE/TSE y tabla de análisis)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:
Propiedades químicas y físicas
| Solubilidad | DMSO : 20.83 mg/mL (45.50 mM; Need ultrasonic) |
|---|
Calculadoras de soluciones
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