Information
Guaifenesin is an expectorant used to relieve chest congestion.
In vitro
In vivo
Guaifenesin (200 mg/kg, intravenously) combined with ketamine (50 mg/kg, intramuscularly) produces effective and safe surgical anesthesia for over 30 minutes in New Zealand white rabbits. Guaifenesin (200 mg/kg, intravenously) combined with ketamine (50 mg/kg, intramuscularly) mildly depresses respiratory rate but heart rate and arterial blood pressure are not significantly affected. Guaifenesin (200 mg/kg, intravenously) is combined with sodium pentobarbital (20 mg/kg, intravenously) to produce surgical anesthesia for a period of more than 30 minutes. Guaifenesin (50 mg/mL) combined Xylazine (0.1 mg/mL) and Ketamine (1.0 mg/mL) results in excellent anesthetic induction and maintenance with cardiopulmonary alterations similar to those associated with isoflurane in mechanically ventilated calves. Guaifenesin (150 mg/kg) decreases spectral edge frequency (SEF) and total power in pigs. Guaifenesin prevents adverse anesthetic induction events caused by Propofol in horse. Guaifenesin (90 mg/kg) followed by Propofol (3 mg/kg) should be sufficient to immobilize > 99% of calm healthy adult horses. Guaifenesin (100 mg/kg) produces moderate behavioral changes in the social conflict test in mice. Guaifenesin (200 mg/kg) combined with Paracetamol (200 mg/kg) causes significantly more pronounced analgesic effects that the corresponding doses of paracetamol alone in mice.
Cell Data
cell lines：
Concentrations：
Incubation Time：
Powder Purity:≥99%
| ALogP | 1.4 |
|---|
| Isómeros SMILES | COC1=CC=CC=C1OCC(CO)O |
|---|---|
| WGK Alemania | 1 |
| RTECS | TY8400000 |
| Peso molecular | 198.22 |
| Reaxy-Rn | 3200276 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=3200276&ln= |
Comprehensive hazard, handling, storage, and regulatory compliance document.
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View spec sheet →| Punto de ebullición (°C) | 215°C/19mm |
|---|---|
| Punto de fusión (°C) | 83°C |
| 1. Shuqi Guo, Falin He, Shaoyang Hu, Wansong Zong, Rutao Liu. (2023) Novel evidence on iodoacetic acid-induced immune protein functional and conformational changes: Focusing on cellular and molecular aspects. SCIENCE OF THE TOTAL ENVIRONMENT, [PMID:38103599] [10.1016/j.scitotenv.2023.169359] |
| 2. Yuanjiao Liu, Yi Wang, Songyao Zhang, Hengqi Zou, Xinrui Miao, Wenli Deng. (2023) Fabricating 2D Host −Guest Kagomé Packing for C2-Symmetric Aromatic Carboxylic Acids with Different Spatial Configuration: Different Ways, Same Destination. Journal of Physical Chemistry C, [PMID:] [10.1021/acs.jpcc.2c08436] |
| 3. Yongzhi San, Minghua Wang. (2025) Cordycepin Ameliorates Kainic Acid-Induced HT22 Cell Neurotoxicity by Activating GPR120-Mediated Mitophagy. Developmental Neurobiology, 85 (2): (e22961). [PMID:40007070] [10.1002/dneu.22961] |
