H-Ile-Pro-Pro-OH hydrochloride - ≥98% , CAS No.1208862-61-6

CAS: 1208862-61-6 Cat. No.: H648761 Peso molecular: 361.86 PubChem CID: 146673017

GRADE & PURITY ≥98%

Storage

Protected from light,Desiccated,Store at -80°C

Shipped In

Dry ice packs + Cold packs

Descripción general

H-Ile-Pro-Pro-OH hydrochloride, a milk-derived peptide , inhibits angiotensin-converting enzyme ( ACE ) with an IC 50 of 5 μM . Antihypertensive tripeptides

In Vitro

Ile-Pro-Pro (IPP; 1 nM, 0.1 μM, and 10 μM) increases nitric oxide (NO) production in human umbilical vein endothelial cells (HUVECs). MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Ile-Pro-Pro (IPP; 30 mg/kg per day; 0.3 g/L) attenuates arterial dysfunction in L-NAME-treated rats Ile-Pro-Pro decreases blood pressure in spontaneously hypertensive rats (SHR) . Ile-Pro-Pro attenuates the development of atherosclerosis in apolipoprotein E-deficient (apoE(-/-)) mice . MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

IC50& Target:IC50: 5 μM (ACE)

Specifications

Especificaciones y pureza

≥98%

Mecanismos bioquímicos y fisiológicos

H-Ile-Pro-Pro-OH hydrochloride, a milk-derived peptide, inhibits angiotensin-converting enzyme ( ACE )with an IC 50 of 5 μM. Antihypertensive tripeptides.

Condiciones de almacenamiento de almacenamiento

Protected from light, Desiccated, Store at -80°C

Enviado en

Dry ice packs + Cold packs

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Tipo de acción

INHIBITOR

Pureza

≥98%

Nombres e identificadores

• Sonrisas canónicas: CCC(C)C(C(=O)N1CCCC1C(=O)N2CCCC2C(=O)O)N.Cl
• IUPAC Name: (2S)-1-[(2S)-1-[(2S,3S)-2-amino-3-methylpentanoyl]pyrrolidine-2-carbonyl]pyrrolidine-2-carboxylic acid;hydrochloride
• InChIKey: XRXZJOQURIUXLP-KRBYAKJKSA-N
• INCHI: 1S/C16H27N3O4.ClH/c1-3-10(2)13(17)15(21)18-8-4-6-11(18)14(20)19-9-5-7-12(19)16(22)23;/h10-13H,3-9,17H2,1-2H3,(H,22,23);1H/t10-,11-,12-,13-;/m0./s1
• PubChem CID: 146673017
• Peso molecular: 361.86

Propiedades químicas y físicas

• Solubilidad: H2O : 55 mg/mL (151.99 mM; Need ultrasonic) DMSO : 36.67 mg/mL (101.34 mM; Need ultrasonic)