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Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Harman- 13 C 2 , 15 N is 13 C and 15 N labeled Harmane. Harmane is a benzodiazepine receptor inhibitor ( IC 50 =7 μM), with IC 50 values for mACh , Opioid Receptor , MAO-A/B , and α2-adrenergic receptor of 24 μM, 2.8 μM, 0.5 μM, 5 μM, and 18 μM, respectively. Harmane also inhibits haloperidol and serotonin , with IC 50 values of 163 μM and 101 μM, respectively. Harmane inhibits the I1 imidazoline receptor ( IC 50 =30 nM) to reduce blood pressure and has antidepressant, anti-anxiety, anticonvulsant, and analgesic effects. Harmane inhibits dopamine biosynthesis by decreasing tyrosine hydroxylase (TH) activity and enhancing L-DOPA-induced cytotoxicity in PC12 cells. Additionally, Harmane can increase the mutagenic effect induced by 2-acetylaminofluorene (AAF).
| Sonrisas canónicas | CC1=NC=CC2=C1NC3=CC=CC=C23 |
|---|---|
| IUPAC Name | 1-methyl-9H-(5,6-13C2,115N)pyridino[3,4-b]indole |
| InChIKey | PSFDQSOCUJVVGF-NSFXFQGJSA-N |
| INCHI | 1S/C12H10N2/c1-8-12-10(6-7-13-8)9-4-2-3-5-11(9)14-12/h2-7,14H,1H3/i6+1,7+1,13+1 |
| Isómeros SMILES | CC1=[15N][13CH]=[13CH]C2=C1NC3=CC=CC=C32 |
| PubChem CID | 46781678 |
| Peso molecular | 185.2 |
Comprehensive hazard, handling, storage, and regulatory compliance document.
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