Harringtonolide - ≥98% , CAS No.64761-48-4

CAS: 64761-48-4 Cat. No.: H651650 Peso molecular: 310.34 PubChem CID: 188356

GRADE & PURITY ≥98%

Synonyms

Harringtonolide | 5,11-Dimethyl-2a,4a,9,10,10b,10c-hexahydro-1H-3,10a-methano-2,4-dioxacyclohepta[bc]cyclopenta[jk]acenaphthylene-1,7(3H)-dione | F83950 | (11s,12r,13s,19r)-8,19-dimethyl-14,17-dioxahexacyclo[13.3.1.01,11.04,10.09,13.012,16]nonadeca-4,7,9-

Storage

Protected from light,Store at -80°C

Shipped In

Dry ice packs + Cold packs

Descripción general

Harringtonolide is a potent RACK1 inhibitor ( IC 50 =39.66 μM in A375 cells). Harringtonolide inhibits the epithelial-mesenchymal transition (EMT) process and cell proliferation by affecting the interaction between FAK and RACK1 . Harringtonolide has plant growth inhibitory, antiviral, anti-inflammatory, and antiproliferation activities

In Vitro

Harringtonolide (0-50 μM; 24 hours) exhibits good antiproliferation activity in A375 cells with IC 50 of 39.66 μM. Harringtonolide (0-20 μM; 1 hour) restrains the proteolysis of RACK1 by Pronase, and protects temperature-dependent degradation of RACK1. Harringtonolide (0-4 μM; 24 hours) suppresses the phosphorylation of FAK dose-dependently and inhibits Src and STAT3, the downstream proteins of FAK. Harringtonolide (0-4 μM; 24 hours) dose-dependently inhibits the RACK1–FAK interaction in A375 cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Proliferation Assay Cell Line: A375 melanoma cellsConcentration: 0-50 μM Incubation Time: 24 hours Result: Showed good antiproliferation activity with IC 50 of 39.66 μM. Western Blot Analysis Cell Line: A375 melanoma cellsConcentration: 0, 0.5, 1, 2, 4 μM Incubation Time: 24 hours Result: Suppressed the phosphorylation of FAK dose-dependently and inhibited Src and STAT3, the downstream proteins of FAK.

Form:Solid

IC50& Target:IC 50 : 39.66 μM (RACK1) in A375 cells

Specifications

Sinónimos

Harringtonolide | 5, 11-Dimethyl-2a, 4a, 9, 10, 10b, 10c-hexahydro-1H-3, 10a-methano-2, 4-dioxacyclohepta[bc]cyclopenta[jk]acenaphthylene-1, 7(3H)-dione | F83950 | (11s, 12r, 13s, 19r)-8, 19-dimethyl-14, 17-dioxahexacyclo[13.3.1.01, 11.04, 10.09, 13.012, 16]nonadeca-4, 7, 9-

Especificaciones y pureza

≥98%

Mecanismos bioquímicos y fisiológicos

Harringtonolide is a potent RACK1 inhibitor ( IC 50 =39.66 μM in A375 cells). Harringtonolide inhibits the epithelial-mesenchymal transition (EMT) process and cell proliferation by affecting the interaction between FAK and RACK1 . Harringtonolide has plan

Condiciones de almacenamiento de almacenamiento

Protected from light, Store at -80°C

Enviado en

Dry ice packs + Cold packs

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Tipo de acción

INHIBITOR

Pureza

≥98%

Nombres e identificadores

• Sonrisas canónicas: CC1C2C3C4C5C1(CCC6=CC(=O)C=C(C(=C56)C4O2)C)C(=O)O3
• IUPAC Name: (11S,12R,13S,19R)-8,19-dimethyl-14,17-dioxahexacyclo[13.3.1.01,11.04,10.09,13.012,16]nonadeca-4,7,9-triene-6,18-dione
• InChIKey: QNJIIOHVULPMRL-OFSDVKARSA-N
• INCHI: 1S/C19H18O4/c1-7-5-10(20)6-9-3-4-19-8(2)15-17(23-18(19)21)13-14(19)12(9)11(7)16(13)22-15/h5-6,8,13-17H,3-4H2,1-2H3/t8-,13+,14+,15?,16+,17?,19?/m0/s1
• Isómeros SMILES: C[C@H]1C2C3[C@@H]4[C@@H]5C1(CCC6=CC(=O)C=C(C(=C56)[C@H]4O2)C)C(=O)O3
• CAS alternativo: 64761-48-4
• PubChem CID: 188356
• Términos de entrada MeSH: hainanolide;harringtonolide
• Peso molecular: 310.34

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Clase Furopyrans

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Clase: Furopyrans
• Subclass: Not available
• Intermediate Tree Nodes: Not available
• Direct Parent: Furopyrans
• Alternative Parents: Tropones Oxepanes Delta valerolactones Pyrans Oxanes Tetrahydrofurans Furans Cyclic ketones Carboxylic acid esters Oxacyclic compounds Monocarboxylic acids and derivatives Dialkyl ethers Organic oxides
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Furopyran - Tropone - Oxepane - Delta_valerolactone - Delta valerolactone - Pyran - Oxane - Tetrahydrofuran - Furan - Cyclic ketone - Lactone - Carboxylic acid ester - Oxacycle - Monocarboxylic acid or derivatives - Ether - Dialkyl ether - Carboxylic acid derivative - Organic oxygen compound - Organic oxide - Hydrocarbon derivative - Organooxygen compound - Carbonyl group - Aromatic heteropolycyclic compound
• Descripción: This compound belongs to the class of organic compounds known as furopyrans. These are organic polycyclic compounds containing a furan ring fused to a pyran ring. Furan is a five-membered aromatic ring with four carbon atoms and one oxygen atom. Pyran a six-membered heterocyclic, non-aromatic ring, made up of five carbon atoms and one oxygen atom and containing two double bonds.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y