HDSF - ≥96% , CAS No.86855-26-7

CAS: 86855-26-7 Cat. No.: H331899 Peso molecular: 308.5 Beilstein Registry Number: 4411921

GRADE & PURITY ≥96%

Synonyms

palmitylsulphonyl fluoride | 1-Hexadecanesulfonylfluoride | 1-Hexadecanesulfonyl fluoride | 1-HEXADECYLSULFONYL FLUORIDE | SYL-374 | Hexadecanesulfonyl fluoride | HY-125967 | AM 374 | BDBM50396293 | CHEBI:43275 | hexadecane-1-sulfonyl fluoride | Hexadecyl

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Descripción general

Product Describtion:

HDSF is a serine-specific, active site-directed, modifying agent that acts as an irreversible inhibitor of Cln1 (palmitoyl-protein thioesterase-1 (Ki = 125 μM)). HDSF inhibits lipase, but not phospholipase C activity in Pseudomonas aeruginosa culture supernatant and phospholipase A activity in E. coli.

Specifications

Sinónimos

palmitylsulphonyl fluoride | 1-Hexadecanesulfonylfluoride | 1-Hexadecanesulfonyl fluoride | 1-HEXADECYLSULFONYL FLUORIDE | SYL-374 | Hexadecanesulfonyl fluoride | HY-125967 | AM 374 | BDBM50396293 | CHEBI:43275 | hexadecane-1-sulfonyl fluoride | Hexadecyl

Especificaciones y pureza

≥96%

Condiciones de almacenamiento de almacenamiento

Store at -20°C

Enviado en

Ice chest + Ice pads

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Tipo de acción

INHIBITOR

Pureza

≥96%

Propiedades del producto

• Datos Ki: Cln1: Ki= 125 μM

Nombres e identificadores

• Pubchem Sid: 488179777
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/488179777
• Sonrisas canónicas: CCCCCCCCCCCCCCCCS(=O)(=O)F
• IUPAC Name: hexadecane-1-sulfonyl fluoride
• InChIKey: QIVFMUVBIHIZAM-UHFFFAOYSA-N
• INCHI: 1S/C16H33FO2S/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-20(17,18)19/h2-16H2,1H3
• Isómeros SMILES: CCCCCCCCCCCCCCCCS(=O)(=O)F
• Peso molecular: 308.5
• Beilstein: 4411921
• Reaxy-Rn: 4411921
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=4411921&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organohalogen compounds
    • Clase Sulfonyl halides
      • Subclass Sulfonyl fluorides

• Kingdom: Organic compounds
• Superclass: Organohalogen compounds
• Clase: Sulfonyl halides
• Subclass: Sulfonyl fluorides
• Intermediate Tree Nodes: Not available
• Direct Parent: Sulfonyl fluorides
• Alternative Parents: Sulfonyls Organosulfonic acids and derivatives Organic oxides Hydrocarbon derivatives
• Molecular Framework: Aliphatic acyclic compounds
• Substituents: Sulfonyl - Sulfonyl fluoride - Organosulfonic acid or derivatives - Organic sulfonic acid or derivatives - Organic oxygen compound - Organic oxide - Hydrocarbon derivative - Organosulfur compound - Aliphatic acyclic compound
• Descripción: This compound belongs to the class of organic compounds known as sulfonyl fluorides. These are compounds containing a sulfonyl (R-S(=O)2-R') functional group singly bonded to a fluorine atom.
• External Descriptors: acyl fluoride

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Objetivos asociados (humanos)

LPL Tchem Lipoprotein lipase (101 Activities)

Discover Target: LPL

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MGLL Tchem Monoglyceride lipase (1909 Activities)

Discover Target: MGLL

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Objetivos asociados (no humanos)

Faah Anandamide amidohydrolase (3907 Activities)

Discover Target: Faah

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mecanismos de acción

Propiedades químicas y físicas

• Solubilidad: Soluble in DMSO (10 mg/ml).
• Índice de refracción: n20D1.45 (Predicted)
• Punto de inflamación (°C): 188.6ºC
• Punto de ebullición (°C): 388.3ºC at 760 mmHg
• Peso molecular: 308.500 g/mol
• XLogP3: 7.900
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 15
• Exact Mass: 308.219 Da
• Monoisotopic Mass: 308.219 Da
• Topological Polar Surface Area: 42.500 Ų
• Heavy Atom Count: 20
• Formal Charge: 0
• Complexity: 283.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1