HLY78 - Moligand™,≥98% , CAS No.854847-61-3

CAS: 854847-61-3 Cat. No.: H651654 Peso molecular: 267.32 Número EC: 806-183-0 PubChem CID: 44422459

GRADE & PURITY Moligand™, ≥98%

Synonyms

AKOS037643437 | SCHEMBL15995588 | 4-Ethyl-5-methyl-5,6-dihydro-[1,3]dioxolo[4,5-j]phenanthridine | A900672 | AC-36980 | 4-ethyl-5-methyl-8,9-methylenedioxy-5,6-dihydrophenanthridine | HLY78 | HLY-78 | 4-Ethyl-5-methyl-8,9-methylenedioxy-5,6-dihydrophenant

Storage

Protected from light,Store at -20°C,Argon charged

Shipped In

Ice chest + Ice pads

Descripción general

HLY78, a Lycorine derivative, is a potent activator of the Wnt/β-catenin signaling pathway. HLY78 targets the DIX domain of Axin and promotes the Axin-LRP6 (lipoprotein receptor-related protein 6) association, thus promoting LRP6 phosphorylation and Wnt signal transduction. HLY78 can be used for subarachnoid hemorrhage (SAH) research

Specifications

Sinónimos

AKOS037643437 | SCHEMBL15995588 | 4-Ethyl-5-methyl-5, 6-dihydro-[1, 3]dioxolo[4, 5-j]phenanthridine | A900672 | AC-36980 | 4-ethyl-5-methyl-8, 9-methylenedioxy-5, 6-dihydrophenanthridine | HLY78 | HLY-78 | 4-Ethyl-5-methyl-8, 9-methylenedioxy-5, 6-dihydrophenant

Especificaciones y pureza

Moligand™, ≥98%

Mecanismos bioquímicos y fisiológicos

HLY78, a Lycorine ( HY-N0288 ) derivative, is a potent activator of the Wnt/β-catenin signaling pathway. HLY78 targets the DIX domain of Axin and promotes the Axin-LRP6 (lipoprotein receptor-related protein 6) association, thus promoting LRP6 phosphorylat

Condiciones de almacenamiento de almacenamiento

Protected from light, Store at -20°C, Argon charged

Enviado en

Ice chest + Ice pads

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Grado

Moligand™

Tipo de acción

INHIBITOR

Pureza

≥98%

Nombres e identificadores

• Sonrisas canónicas: CCC1=C2C(=CC=C1)C3=CC4=C(C=C3CN2C)OCO4
• IUPAC Name: 4-ethyl-5-methyl-6H-[1,3]dioxolo[4,5-j]phenanthridine
• InChIKey: FAZZYPIBZBGQSH-UHFFFAOYSA-N
• INCHI: 1S/C17H17NO2/c1-3-11-5-4-6-13-14-8-16-15(19-10-20-16)7-12(14)9-18(2)17(11)13/h4-8H,3,9-10H2,1-2H3
• Isómeros SMILES: CCC1=C2C(=CC=C1)C3=CC4=C(C=C3CN2C)OCO4
• WGK Alemania: 3
• PubChem CID: 44422459
• Peso molecular: 267.32

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Clase Quinolines and derivatives
      • Subclass Benzoquinolines

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Clase: Quinolines and derivatives
• Subclass: Benzoquinolines
• Intermediate Tree Nodes: Not available
• Direct Parent: Phenanthridines and derivatives
• Alternative Parents: Benzodioxoles Dialkylarylamines Aralkylamines Benzenoids Oxacyclic compounds Azacyclic compounds Acetals Organopnictogen compounds Hydrocarbon derivatives
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Phenanthridine - Benzodioxole - Tertiary aliphatic/aromatic amine - Dialkylarylamine - Aralkylamine - Benzenoid - Tertiary amine - Acetal - Oxacycle - Azacycle - Organopnictogen compound - Organic oxygen compound - Organooxygen compound - Organonitrogen compound - Organic nitrogen compound - Hydrocarbon derivative - Amine - Aromatic heteropolycyclic compound
• Descripción: This compound belongs to the class of organic compounds known as phenanthridines and derivatives. These are polycyclic compounds containing a phenanthridine moiety, which is a tricyclic system with two benzene rings joined by a pyridine forming a non-linear skeleton. Hydrogenated derivatives are also included.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Objetivos asociados (humanos)

ACHE Tclin Acetylcholinesterase (18204 Activities)

Discover Target: ACHE

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mecanismos de acción

Propiedades químicas y físicas

• Solubilidad: DMSO : 26 mg/mL (97.26 mM; Need ultrasonic)
• Sensibilidad: Light sensitive
• Peso molecular: 267.320 g/mol
• XLogP3: 3.900
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 267.126 Da
• Monoisotopic Mass: 267.126 Da
• Topological Polar Surface Area: 21.700 Ų
• Heavy Atom Count: 20
• Formal Charge: 0
• Complexity: 361.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1