Homatropine Bromide - 10mM in DMSO , CAS No.51-56-9

CAS: 51-56-9 Cat. No.: H407885 Peso molecular: 356.27 Número EC: 200-105-3

GRADE & PURITY 10mM in DMSO

Synonyms

Benzeneacetic acid, α-hydroxy-, (3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester, hydrobromide (1:1)

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Descripción general

Information

Homatropine Bromide is an muscarinicAChRantagonist, inhibits endothelial and smooth muscle muscarinic receptors of WKY-E and SHR-E withIC50of 162.5 nM and 170.3 nM, respectively.
In vitro

Homatropine (20 μM) alone produces a dose ratio of 259 in atrium from guinea-pigs. Homatropine (20 μM) produces a dose ratio of only 95.0 when combined with hexamethonium in atrium from guinea-pigs. Homatropine has similar affinities for muscarinic receptors in stomach (pA2 = 7.13) and for those in atria mediating force (pA2 = 7.21) and rate (pA2 = 7.07) responses.

In vivo

Homatropine (20 mg/kg) prevents lethality in rats with dichlorvos poisoning with survive rate of 30% and time of death ranged between 4 and 12 minutes, while Homatropine (10 mg/kg) has no effect on preventing lethality. Homatropine [¹⁴C]methylbromide administrated rectal achieves higher and rapid peak plasma concentrations than by the other routes in rats whether HMB-14C is administered in a water-soluble suppository base or in aqueous solution, retained 28% of the 14C has been excreted in the urine while 56% remained in the large intestine after 12 hours. Unlabelled Homatropine methylbromide, given in rectal suppositories to anaesthetized rats, causes prompt blockade of the effects of vagal stimulation on pulse rate and of intravenous acetylcholine on blood pressure.
Cell Data

cell lines：HEKn cells

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

Sinónimos

Benzeneacetic acid, α-hydroxy-, (3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester, hydrobromide (1:1)

Especificaciones y pureza

10mM in DMSO

Mecanismos bioquímicos y fisiológicos

Homatropine Bromide is an muscarinic AChR antagonist, inhibits endothelial and smooth muscle muscarinic receptors of WKY-E and SHR-E with IC50 of 162.5 nM and 170.3 nM, respectively.

Condiciones de almacenamiento de almacenamiento

Store at -80°C

Enviado en

Dry ice packs + Cold packs

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Nombres e identificadores

• Isómeros SMILES: CN1[C@@H]2CC[C@H]1CC(C2)OC(=O)C(C3=CC=CC=C3)O.Br
• Peso molecular: 356.27
• Reaxy-Rn: 4166020
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=4166020&ln=

Propiedades químicas y físicas

• Solubilidad: Solubility (25°C) In vitro DMSO: 60 mg/mL (201.14 mM); Ethanol: 2 mg/mL (6.7 mM); Water: Insoluble