≥99% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Information
HPOB is a potent, selectiveHDAC6inhibitor withIC50of 56 nM, >30-fold selectivity over other HDACs.
Targets
HDAC6 ; HDAC3 ; HDAC8 ; HDAC1 ; HDAC10 14965,56 nM; 1.7 μM; 2.8 μM; 2.9 μM; 3.0 μM
In vitro
In normal (HFS) and transformed (LNCaP, A549, and U87) cells, HPOB induces acetylation of α-tubulin, however, not histones, and inhibits cell growth, however, not viability. In HFS cells, HPOB enhances transformed cell death induced by etoposide, doxorubicin, or SAHA. HPOB also enhancing etoposide-induced transformed cell death via the apoptotic pathway in transformed cells.
In vivo
In mice bearing CWR22 human prostate cancer xenografts, HPOB (300 mg/kg/d i.p.), when in combination with SAHA, causes suppression of the growth of established tumors, while produces no significant suppression when used alone.
Cell Research(from reference)
Cell lines：HFS, A549, LNCaP, and U87 cells
Concentrations：~32 μM
Incubation Time：72 hours
| Sonrisas canónicas | C1=CC=C(C=C1)N(CCO)C(=O)CC2=CC=C(C=C2)C(=O)NO |
|---|---|
| IUPAC Name | N-hydroxy-4-[2-[N-(2-hydroxyethyl)anilino]-2-oxoethyl]benzamide |
| InChIKey | RFAZNTABYJYOAR-UHFFFAOYSA-N |
| INCHI | 1S/C17H18N2O4/c20-11-10-19(15-4-2-1-3-5-15)16(21)12-13-6-8-14(9-7-13)17(22)18-23/h1-9,20,23H,10-12H2,(H,18,22) |
| Isómeros SMILES | C1=CC=C(C=C1)N(CCO)C(=O)CC2=CC=C(C=C2)C(=O)NO |
| Peso molecular | 314.34 |
| Reaxy-Rn | 23515709 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=23515709&ln= |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →Taxonomy Tree
| Kingdom | Organic compounds |
|---|---|
| Superclass | Benzenoids |
| Clase | Benzene and substituted derivatives |
| Subclass | Phenylacetamides |
| Intermediate Tree Nodes | Not available |
| Direct Parent | Phenylacetamides |
| Alternative Parents | Benzoic acids and derivatives Anilides Benzoyl derivatives Tertiary carboxylic acid amides Hydroxamic acids Alkanolamines Primary alcohols Organic oxides Hydrocarbon derivatives Carbonyl compounds |
| Molecular Framework | Aromatic homomonocyclic compounds |
| Substituents | Phenylacetamide - Benzoic acid or derivatives - Anilide - Benzoyl - Tertiary carboxylic acid amide - Hydroxamic acid - Carboxamide group - Carboxylic acid derivative - Alkanolamine - Organic oxide - Organic oxygen compound - Primary alcohol - Organooxygen compound - Organonitrogen compound - Carbonyl group - Alcohol - Organic nitrogen compound - Hydrocarbon derivative - Aromatic homomonocyclic compound |
| Descripción | This compound belongs to the class of organic compounds known as phenylacetamides. These are amide derivatives of phenylacetic acids. |
| External Descriptors | Not available |
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Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Fecha | Articulo |
|---|---|---|---|
 I2523096 | Certificate of Analysis | Oct 10, 2025 | H413730 |
| G23181231 | Certificate of Analysis | May 09, 2025 | H413730 |
| G23181232 | Certificate of Analysis | May 09, 2025 | H413730 |
| G23181242 | Certificate of Analysis | May 09, 2025 | H413730 |
| G23181245 | Certificate of Analysis | May 09, 2025 | H413730 |
| G23181246 | Certificate of Analysis | May 09, 2025 | H413730 |
| G23181250 | Certificate of Analysis | May 09, 2025 | H413730 |
| Solubilidad | Solubility (25°C) In vitro DMSO: 62 mg/mL (197.23 mM); Ethanol: 38 mg/mL warmed with 50ºC Water: bath (120.88 mM); Water: Insoluble; |
|---|---|
| Peso molecular | 314.340 g/mol |
| XLogP3 | 1.000 |
| Hydrogen Bond Donor Count | 3 |
| Hydrogen Bond Acceptor Count | 4 |
| Rotatable Bond Count | 6 |
| Exact Mass | 314.127 Da |
| Monoisotopic Mass | 314.127 Da |
| Topological Polar Surface Area | 89.900 Ų |
| Heavy Atom Count | 23 |
| Formal Charge | 0 |
| Complexity | 388.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 0 |
| Covalently-Bonded Unit Count | 1 |
