HS024 TFA, Antagonist of MC 1 receptor;Antagonist of MC 3 receptor;Antagonist of MC 4 receptor;Antagonist of MC 5 receptor, CAS No.212370-59-7(free base), Antagonist of MC 1 receptor;Antagonist of MC 3 receptor;Antagonist of MC 4 receptor;Antagonist of MC 5 receptor

CAS: 212370-59-7(free base) Cat. No.: H288535 Peso molecular: 1266.50(free base)

GRADE & PURITY Moligand™, ≥95%

Specifications

Product Name

HS024 TFA, Antagonist of MC 1 receptor;Antagonist of MC 3 receptor;Antagonist of MC 4 receptor;Antagonist of MC 5 receptor, CAS No.212370-59-7(free base)

Sinónimos

AKOS024456803 | HS 024 | N-Acetyl-L-cysteinyl-L-norleucyl-L-arginyl-L-histidyl-3-(2-naphthalenyl)-D-alanyl-L-arginyl-L-tryptophylglycyl-L-cysteinamide cyclic (1->9)disulfide | HS024 | DTXSID301034918 | Long Name (Added to Synonym)

Grado

Moligand™

Especificaciones y pureza

Moligand™, ≥95%

Mecanismos bioquímicos y fisiológicos

Highly potent melanocortin MC4receptor antagonist (Kivalues are 0.29, 18.6, 5.45 and 3.29 nM for cloned human MC4, MC1, MC3and MC5receptors respectively). Increases food intake, and blocksα-MSH- and MTII-induced hypotension and bradycardia in rats, follow

Secuencia

CXRHXRWGC(Modifications: Cys-1 = N-terminal Ac, X-2 = Nle, X-5 = Nal, Cys-9 = C-terminal amide, Disulfide bridge between 1 - 9)

Tipo de acción

ANTAGONIST

Mecanismo de acción

Antagonist of MC 1 receptor;Antagonist of MC 3 receptor;Antagonist of MC 4 receptor;Antagonist of MC 5 receptor

CAS

212370-59-7(free base)

Tipo de molécula

Peptide

Almacenamiento y envío

Condiciones de almacenamiento de almacenamiento

Store at -20°C,Desiccated

Enviado en

Ice chest + Ice pads

Objetivos asociados (humanos)

MC5R Tchem Melanocortin receptor 5 (0 Activities)

Discover Target: MC5R

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MC4R Tclin Melanocortin receptor 4 (0 Activities)

Discover Target: MC4R

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MC3R Tchem Melanocortin receptor 3 (0 Activities)

Discover Target: MC3R

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MC1R Tclin Melanocyte-stimulating hormone receptor (0 Activities)

Discover Target: MC1R

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Información genética

• Alternate Names: AKOS024456803 | HS 024 | N-Acetyl-L-cysteinyl-L-norleucyl-L-arginyl-L-histidyl-3-(2-naphthalenyl)-D-alanyl-L-arginyl-L-tryptophylglycyl-L-cysteinamide cyclic (1->9)disulfide | HS024 | DTXSID301034918 | Long Name (Added to Synonym)
• Reference:
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