Hydroxytacrine maleate - Moligand™,≥98% , CAS No.118909-22-1

CAS: 118909-22-1 Cat. No.: A132455 Peso molecular: 330.34 PubChem CID: 5702293

GRADE & PURITY Moligand™, ≥98%

Synonyms

P83 6029A | Caswell No. 207E | Mentane | SR-01000075908-1 | Velnacrine maleate (USAN) | BRN 2136026 | H 3146 | VELNACRINE MALEATE [MI] | 1-Acridinol, 9-amino-1,2,3,4-tetrahydro-, (-)-, (2Z)-2-butenedioate (1:1) (salt) | 1-ACRIDINOL, 9-AMINO-1,2,3,4-TETRAH

Storage

Protected from light,Store at -20°C,Argon charged

Shipped In

Ice chest + Ice pads

Descripción general

Hydroxytacrine maleate (Velnacrine maleate) is a cholinesterase (cholinesterase) inhibitor that enhances memory in rodents and may be used in the study of Alzheimer's dementia of the Alzheimer type (SDAT).

Specifications

Sinónimos

P83 6029A | Caswell No. 207E | Mentane | SR-01000075908-1 | Velnacrine maleate (USAN) | BRN 2136026 | H 3146 | VELNACRINE MALEATE [MI] | 1-Acridinol, 9-amino-1, 2, 3, 4-tetrahydro-, (-)-, (2Z)-2-butenedioate (1:1) (salt) | 1-ACRIDINOL, 9-AMINO-1, 2, 3, 4-TETRAH

Especificaciones y pureza

Moligand™, ≥98%

Mecanismos bioquímicos y fisiológicos

Hydroxytacrine maleate is a cholinesterase inhibitor and a potential Alzheimer’s therapeutic of low toxicity. Exhibits biochemical and pharmacological profile similar to tacrine (THA) except that it is far less toxic and without measurable liver toxicity

Condiciones de almacenamiento de almacenamiento

Protected from light, Store at -20°C, Argon charged

Enviado en

Ice chest + Ice pads

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Grado

Moligand™

Tipo de acción

INHIBITOR

Pureza

≥98%

Nombres e identificadores

• Sonrisas canónicas: C1CC(C2=C(C3=CC=CC=C3N=C2C1)N)O.C(=CC(=O)O)C(=O)O
• IUPAC Name: 9-amino-1,2,3,4-tetrahydroacridin-1-ol;(Z)-but-2-enedioic acid
• InChIKey: NEEKVKZFYBQFGT-BTJKTKAUSA-N
• INCHI: 1S/C13H14N2O.C4H4O4/c14-13-8-4-1-2-5-9(8)15-10-6-3-7-11(16)12(10)13;5-3(6)1-2-4(7)8/h1-2,4-5,11,16H,3,6-7H2,(H2,14,15);1-2H,(H,5,6)(H,7,8)/b;2-1-
• Isómeros SMILES: C1CC(C2=C(C3=CC=CC=C3N=C2C1)N)O.C(=C\C(=O)O)\C(=O)O
• PubChem CID: 5702293
• Peso molecular: 330.34

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Clase Quinolines and derivatives
      • Subclass Benzoquinolines

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Clase: Quinolines and derivatives
• Subclass: Benzoquinolines
• Intermediate Tree Nodes: Not available
• Direct Parent: Acridines
• Alternative Parents: 4-aminoquinolines Aminopyridines and derivatives Unsaturated fatty acids Dicarboxylic acids and derivatives Benzenoids Heteroaromatic compounds Secondary alcohols Carboxylic acids Azacyclic compounds Primary amines Organopnictogen compounds Organic oxides Hydrocarbon derivatives Carbonyl compounds
• Molecular Framework: Not available
• Substituents: Acridine - Aminoquinoline - 4-aminoquinoline - Aminopyridine - Dicarboxylic acid or derivatives - Pyridine - Fatty acyl - Fatty acid - Benzenoid - Unsaturated fatty acid - Heteroaromatic compound - Secondary alcohol - Carboxylic acid derivative - Carboxylic acid - Azacycle - Organooxygen compound - Organonitrogen compound - Organic oxide - Alcohol - Organic nitrogen compound - Carbonyl group - Organopnictogen compound - Organic oxygen compound - Primary amine - Hydrocarbon derivative - Amine - Aromatic heteropolycyclic compound
• Descripción: This compound belongs to the class of organic compounds known as acridines. These are organic compounds containing the acridine moiety, a linear tricyclic heterocycle which consists of two benzene rings joined by a pyridine ring.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Propiedades químicas y físicas

• Solubilidad: Soluble in water (5 mg/mL warm), DMSO (25 mg/mL), and ethanol (10 mg/mL).
• Sensibilidad: moisture sensitive
• Peso molecular: 330.330 g/mol
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 2
• Exact Mass: 330.122 Da
• Monoisotopic Mass: 330.122 Da
• Topological Polar Surface Area: 134.000 Ų
• Heavy Atom Count: 24
• Formal Charge: 0
• Complexity: 377.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 1
• Defined Bond Stereocenter Count: 1
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 1
• Covalently-Bonded Unit Count: 2

XLogP3