Information
Icatibant Acetate Icatibant Acetate acts as an antagonist of the bradykinin B2 receptor and is used in the treatment of hereditary angioedema.
Targets
bradykinin B2 receptor
In vitro
Icatibant is a decapeptide resistant to the bradykinin-degrading proteases, resulting in a longer half-life than bradykinin which it antagonizes.
In vivo
Icatibant exhibits efficacy in bradykinin-mediated angioedema attacks, and induces rapid symptom relief.
| Pubchem Sid | 504763541 |
|---|---|
| Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/504763541 |
| Sonrisas canónicas | CC(=O)O.C1CCC2C(C1)CC(N2C(=O)C3CC4=CC=CC=C4CN3C(=O)C(CO)NC(=O)C(CC5=CC=CS5)NC(=O)CNC(=O)C6CC(CN6C(=O)C7CCCN7C(=O)C(CCCN=C(N)N)NC(=O)C(CCCN=C(N)N)N)O)C(=O)NC(CCCN=C(N)N)C(=O)O |
| IUPAC Name | (2S)-2-[[(2S,3aS,7aS)-1-[2-[(2S)-2-[[(2S)-2-[[2-[[(2S,4R)-1-[(2S)-1-[(2S)-2-[[(2R)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]-4-hydroxypyrrolidine-2-carbonyl]amino]acetyl]amino]-3-thiophen-2-ylpropanoyl]amino]-3-hydroxypropanoyl]-3,4-dihydro-1H-isoquinoline-3-carbonyl]-2,3,3a,4,5,6,7,7a-octahydroindole-2-carbonyl]amino]-5-(diaminomethylideneamino)pentanoic acid;acetic acid |
| InChIKey | HKMZRZUEADSZDQ-OZPDGATDSA-N |
| INCHI | 1S/C59H89N19O13S.C2H4O2/c60-37(14-5-19-67-57(61)62)48(82)72-38(15-6-20-68-58(63)64)52(86)75-22-8-18-43(75)54(88)77-30-35(80)26-44(77)50(84)70-28-47(81)71-40(27-36-13-9-23-92-36)49(83)74-41(31-79)53(87)76-29-34-12-2-1-10-32(34)24-46(76)55(89)78-42-17-4-3-11-33(42)25-45(78)51(85)73-39(56(90)91)16-7-21-69-59(65)66;1-2(3)4/h1-2,9-10,12-13,23,33,35,37-46,79-80H,3-8,11,14-22,24-31,60H2,(H,70,84)(H,71,81)(H,72,82)(H,73,85)(H,74,83)(H,90,91)(H4,61,62,67)(H4,63,64,68)(H4,65,66,69);1H3,(H,3,4)/t33-,35+,37+,38-,39-,40-,41-,42-,43-,44-,45-,46?;/m0./s1 |
| Isómeros SMILES | CC(=O)O.C1CC[C@H]2[C@@H](C1)C[C@H](N2C(=O)C3CC4=CC=CC=C4CN3C(=O)[C@H](CO)NC(=O)[C@H](CC5=CC=CS5)NC(=O)CNC(=O)[C@@H]6C[C@H](CN6C(=O)[C@@H]7CCCN7C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](CCCN=C(N)N)N)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O |
| PubChem CID | 5311169 |
| Peso molecular | 1304.52（free base） |
Comprehensive hazard, handling, storage, and regulatory compliance document.
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| Lot Number | Certificate Type | Fecha | Articulo |
|---|---|---|---|
 E2627022 | Certificate of Analysis | Jun 05, 2026 | I413312 |
| F2303406 | Certificate of Analysis | Mar 13, 2026 | I413312 |
| F2303408 | Certificate of Analysis | Mar 13, 2026 | I413312 |
| F2303417 | Certificate of Analysis | Mar 13, 2026 | I413312 |
| F2303473 | Certificate of Analysis | Mar 13, 2026 | I413312 |
| F2303485 | Certificate of Analysis | Mar 13, 2026 | I413312 |
| F2303509 | Certificate of Analysis | Mar 13, 2026 | I413312 |
| Solubilidad | Solubility (25°C) In vitro |
|---|---|
| Sensibilidad | Moisture sensitive；Light sensitive |
