ICCB-19 hydrochloride - ≥99% , CAS No.1803605-68-6

CAS: 1803605-68-6 Cat. No.: I413405 Peso molecular: 291.84 Número EC: 862-617-9 PubChem CID: 91654402

GRADE & PURITY ≥99%

Synonyms

EN300-195751 | s6078 | ICCB-19 HCl pound 750621-52-4 free base pound(c) | N-cycloheptyl-2-(4,5-dihydro-1H-imidazol-2-ylsulfanyl)acetamide hydrochloride | E74676 | MS-24169 | EX-A6564 | HY-138779 | ICCB-19 hydrochloride | N-cycloheptyl-2-(4,5-dihydro-1H-im

Storage

Protected from light,Store at -20°C

Shipped In

Ice chest + Ice pads

Descripción general

Information

ICCB-19 hydrochloride ICCB-19 hydrochloride is an inhibitor of TNFRSF1A Associated Via Death Domain (TRADD) with IC50 of 1.12 μM and 2.01 μM for protecting Velcade-induced apoptosis in Jurkat cells and protecting RDA in MEFs, respectively. ICCB-19 indirectly inhibits Receptor-interacting serine/threonine-protein kinase 1 (RIPK1) . ICCB-19 effectively induces autophagy .

Targets

TRADD ; RIPK1

Specifications

Sinónimos

EN300-195751 | s6078 | ICCB-19 HCl pound 750621-52-4 free base pound(c) | N-cycloheptyl-2-(4, 5-dihydro-1H-imidazol-2-ylsulfanyl)acetamide hydrochloride | E74676 | MS-24169 | EX-A6564 | HY-138779 | ICCB-19 hydrochloride | N-cycloheptyl-2-(4, 5-dihydro-1H-im

Especificaciones y pureza

≥99%

Mecanismos bioquímicos y fisiológicos

ICCB-19 hydrochloride is an inhibitor of TNFRSF1A Associated Via Death Domain (TRADD) with IC50 of 1.12 μM and 2.01 μM for protecting Velcade-induced apoptosis in Jurkat cells and protecting RDA in MEFs, respectively. ICCB-19 indirectly inhibits Receptor-

Condiciones de almacenamiento de almacenamiento

Protected from light, Store at -20°C

Enviado en

Ice chest + Ice pads

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Pureza

≥99%

Nombres e identificadores

• Pubchem Sid: 504772630
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504772630
• Sonrisas canónicas: C1CCCC(CC1)NC(=O)CSC2=NCCN2.Cl
• IUPAC Name: N-cycloheptyl-2-(4,5-dihydro-1H-imidazol-2-ylsulfanyl)acetamide;hydrochloride
• InChIKey: TZICOTBZKPHMMK-UHFFFAOYSA-N
• INCHI: 1S/C12H21N3OS.ClH/c16-11(9-17-12-13-7-8-14-12)15-10-5-3-1-2-4-6-10;/h10H,1-9H2,(H,13,14)(H,15,16);1H
• Isómeros SMILES: C1CCCC(CC1)NC(=O)CSC2=NCCN2.Cl
• PubChem CID: 91654402
• Peso molecular: 291.84

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Clase Azolines
      • Subclass Imidazolines

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Clase: Azolines
• Subclass: Imidazolines
• Intermediate Tree Nodes: Not available
• Direct Parent: Imidazolines
• Alternative Parents: Secondary carboxylic acid amides Isothioureas Sulfenyl compounds Propargyl-type 1,3-dipolar organic compounds Carboximidamides Azacyclic compounds Organic oxides Hydrochlorides Hydrocarbon derivatives Carbonyl compounds
• Molecular Framework: Aliphatic heteromonocyclic compounds
• Substituents: 2-imidazoline - Carboxamide group - Isothiourea - Secondary carboxylic acid amide - Carboxylic acid derivative - Carboximidamide - Sulfenyl compound - Propargyl-type 1,3-dipolar organic compound - Organic 1,3-dipolar compound - Azacycle - Hydrocarbon derivative - Organosulfur compound - Organooxygen compound - Organonitrogen compound - Carbonyl group - Organic nitrogen compound - Organic oxygen compound - Hydrochloride - Organic oxide - Aliphatic heteromonocyclic compound
• Descripción: This compound belongs to the class of organic compounds known as imidazolines. These are organic compounds containing an imidazoline ring, which is an unsaturated ring (derived from imidazole) with two nitrogen atoms at positions 1 and 3 respectively, and containing only one CN double bond.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Propiedades químicas y físicas

• Solubilidad: Solubility (25°C) In vitro DMSO: 58 mg/mL (198.73 mM); Water: 58 mg/mL (198.73 mM); Ethanol: 58 mg/mL (198.73 mM)
• Sensibilidad: light sensitive
• Peso molecular: 291.840 g/mol
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 291.117 Da
• Monoisotopic Mass: 291.117 Da
• Topological Polar Surface Area: 78.800 Ų
• Heavy Atom Count: 18
• Formal Charge: 0
• Complexity: 285.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 2

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