Idarubicin HCl - 10mM in DMSO , DNA topoisomerase II alpha inhibitor, CAS No.57852-57-0, DNA topoisomerase II alpha inhibitor

CAS: 57852-57-0 Cat. No.: I408285 Peso molecular: 533.95 Número EC: 260-990-7 PubChem CID: 636362

GRADE & PURITY 10mM in DMSO

Synonyms

4-demethoxydaunorubicin (NSC256439, 4-DMDR) HCl | (7S,9S)-9-acetyl-7-((2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyl-tetrahydro-2H-pyran-2-yloxy)-6,9,11-trihydroxy-7,8,9,10-tetrahydrotetracene-5,12-dione hydrochloride

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Descripción general

Information

Idarubicin HCl (4-demethoxydaunorubicin, NSC256439, 4-DMDR) is a hydrochloride salt form of Idarubicin which is an anthracycline antibiotic and aDNA topoisomerase II (topo II)inhibitor for MCF-7 cells with IC50 of 3.3 ng/mL in a cell-free assay. Idarubici
In vitro

Idarubicin has significant cytotoxic activity against multicellular spheroids, comparable to the antiproliferative effects on monolayer cells. Idarubicin inhibits CYP450 2D6. Idarubicin is about 57.5-fold and 25-fold more active than doxorubicin and epirubicin, respectively. Idarubicin is able to overcome P-glycoprotein-mediated multidrug resistance. Idarubicin inhibits PMN superoxide radical formation. Idarubicin could be coupled to the monoclonal antibodies (anti-Ly-2.1, anti-L3T4, or anti-Thy-1) with retention of protein solubility and antibody activity. Idarubicin inhibits the proliferation of NALM-6 cells with an IC50 of 12 nM.

In vivo

Reduction of Idarubicin is dependent upon ketone reductases, and proceeds more stereoselectively than that of most ketones giving rise to the (13S)-epimer almost exclusively. The high stereospecificity in Idarubicin reduction might result from chiral induction due to the presence of asymmetric centres near to the carbonyl group in Idarubicin.
Cell Data

cell lines：

Concentrations：0.1 nM-10 μM

Incubation Time：24 hours

Powder Purity:≥99%

Specifications

Sinónimos

4-demethoxydaunorubicin (NSC256439, 4-DMDR) HCl | (7S, 9S)-9-acetyl-7-((2R, 4S, 5S, 6S)-4-amino-5-hydroxy-6-methyl-tetrahydro-2H-pyran-2-yloxy)-6, 9, 11-trihydroxy-7, 8, 9, 10-tetrahydrotetracene-5, 12-dione hydrochloride

Especificaciones y pureza

10mM in DMSO

Mecanismos bioquímicos y fisiológicos

Idarubicin HCl (4-demethoxydaunorubicin, NSC256439, 4-DMDR) is a hydrochloride salt form of Idarubicin which is an anthracycline antibiotic and a DNA topoisomerase II (topo II) inhibitor for MCF-7 cells with IC50 of 3.3 ng/mL in a cell-free assay. Idarubi

Condiciones de almacenamiento de almacenamiento

Store at -80°C

Enviado en

Dry ice packs + Cold packs

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Tipo de acción

INHIBITOR

Mecanismo de acción

DNA topoisomerase II alpha inhibitor

Nombres e identificadores

• Isómeros SMILES: C[C@H]1[C@H]([C@H](C[C@@H](O1)O[C@H]2C[C@@](CC3=C2C(=C4C(=C3O)C(=O)C5=CC=CC=C5C4=O)O)(C(=O)C)O)N)O.Cl
• WGK Alemania: 3
• RTECS: HB7877000
• PubChem CID: 636362
• Peso molecular: 533.95

Propiedades químicas y físicas

• Solubilidad: Solubility (25°C) In vitro DMSO: 46 mg/mL (198.09 mM); Ethanol: 6 mg/mL (25.83 mM); Water: Insoluble