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Imaradenant (AZD4635) - Moligand™, ≥98% , Adenosine A2a receptor antagonist, CAS No.1321514-06-0, Adenosine A2a receptor antagonist

CAS: 1321514-06-0 Cat. No.: I414133 Peso molecular: 315.73
COA
Imaradenant (AZD4635) - Moligand™, ≥98% CAS No(1321514-06-0) by Aladdin Scientific
Disponible para pedir
GRADE & PURITY Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
Synonyms
C72299 | S8720 | AZD4635 (HTL1071) | HTL1071 | HTL-1071 | 1321514-06-0 | AKOS037515559 | IMARADENANT [WHO-DD] | 5-(4-fluorophenyl)-6-(2-chloro-6-methyl-pyridin-4-yl)-1,2,4-triazin-3-amine | NCWQLHHDGDXIJN-UHFFFAOYSA-N | HY-101980 | BS-15183 | A16820 | BDB
Storage
Store at -20°C
Shipped In
Ice chest + Ice pads
★
 ·  off list, applied to all prices below.
Size
Estado
Price
Qty
5mg
I414133-5mg
3

40,90US$

61,90US$
Guardar 21,00 US$ (33.93%)
10mg
I414133-10mg
1

57,90US$

86,90US$
Guardar 29,00 US$ (33.37%)
25mg
I414133-25mg
2

98,90US$

148,90US$
Guardar 50,00 US$ (33.58%)
50mg
I414133-50mg
2

165,90US$

248,90US$
Guardar 83,00 US$ (33.35%)
100mg
I414133-100mg
8-12 wks(?) Production requires sourcing of materials. We appreciate your patience and understanding.

279,90US$

419,90US$
Guardar 140,00 US$ (33.34%)
Enter a quantity for the sizes you want to add.
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SDS
Safety data
COA
Certificate
DS
Datasheet
SP
Spec sheet
Descripción general Specifications Propiedades del producto Nombres e identificadores Documentation Advanced Data Taxonomic Classification Estructura 3D Objetivos asociados (humanos) Mecanismos de acción Certificados (CoA, COO, BSE/TSE y tabla de análisis) Propiedades químicas y físicas Calculadoras de soluciones Reseñas
🧪

Why this grade

Moligand™, ≥98% Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

🌡

Storage & shipping

Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.

📋

Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

📚

Literature proof

Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Descripción general

Information

Imaradenant (AZD4635) Imaradenant (AZD4635, HTL1071) is an oral A2AR antagonist that binds to human A2AR with a Ki of 1.7 nM and with > 30-fold selectivity over other adenosine receptors.


Targets

A2AR (Cell-free) 1.7 nM(Ki)


In vitro

In CHO cells stably expressing human A2AR, the IC50s of AZD4635 for inhibition of cAMP production are 0.79, 10.0 and 142.9 nM in the presense of 0.1, 1 and 10 μM adenosine, respectively.


In vivo

Blockade of A2AR signaling with AZD4635 could reduce tumor burden and enhance antitumor immunity.

Specifications

Sinónimos
C72299 | S8720 | AZD4635 (HTL1071) | HTL1071 | HTL-1071 | 1321514-06-0 | AKOS037515559 | IMARADENANT [WHO-DD] | 5-(4-fluorophenyl)-6-(2-chloro-6-methyl-pyridin-4-yl)-1, 2, 4-triazin-3-amine | NCWQLHHDGDXIJN-UHFFFAOYSA-N | HY-101980 | BS-15183 | A16820 | BDB
Especificaciones y pureza
Moligand™, ≥98%
Mecanismos bioquímicos y fisiológicos
Imaradenant (AZD4635, HTL1071) is an oral A2AR antagonist that binds to human A2AR with a Ki of 1.7 nM and with > 30-fold selectivity over other adenosine receptors.
Condiciones de almacenamiento de almacenamiento
Store at -20°C
Enviado en
Ice chest + Ice pads
Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.
Grado
Moligand™
Tipo de acción
ANTAGONIST
Mecanismo de acción
Adenosine A2a receptor antagonist
Pureza
≥98%
Propiedades del producto
ALogP2.6
Nombres e identificadores
Sonrisas canónicasCC1=CC(=CC(=N1)Cl)C2=C(N=C(N=N2)N)C3=CC=C(C=C3)F
IUPAC Name6-(2-chloro-6-methylpyridin-4-yl)-5-(4-fluorophenyl)-1,2,4-triazin-3-amine
InChIKeyNCWQLHHDGDXIJN-UHFFFAOYSA-N
INCHI1S/C15H11ClFN5/c1-8-6-10(7-12(16)19-8)14-13(20-15(18)22-21-14)9-2-4-11(17)5-3-9/h2-7H,1H3,(H2,18,20,22)
Isómeros SMILES CC1=CC(=CC(=N1)Cl)C2=C(N=C(N=N2)N)C3=CC=C(C=C3)F
Peso molecular 315.73
Reaxy-Rn 21716866
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=21716866&ln=

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

KingdomOrganic compounds
SuperclassOrganoheterocyclic compounds
ClaseTriazines
SubclassAminotriazines
Intermediate Tree Nodes Not available
Direct ParentAminotriazines
Alternative Parents Methylpyridines  Fluorobenzenes  2-halopyridines  Aryl fluorides  Aryl chlorides  1,2,4-triazines  Heteroaromatic compounds  Azacyclic compounds  Primary amines  Organofluorides  Organochlorides  Hydrocarbon derivatives  
Molecular FrameworkAromatic heteromonocyclic compounds
Substituents Aminotriazine - 2-halopyridine - Methylpyridine - Fluorobenzene - Halobenzene - Aryl chloride - Aryl fluoride - Aryl halide - Monocyclic benzene moiety - Pyridine - Benzenoid - 1,2,4-triazine - Heteroaromatic compound - Azacycle - Organochloride - Organohalogen compound - Hydrocarbon derivative - Organofluoride - Organonitrogen compound - Primary amine - Organic nitrogen compound - Amine - Aromatic heteromonocyclic compound
DescripciónThis compound belongs to the class of organic compounds known as aminotriazines. These are organic compounds containing an amino group attached to a triazine ring.
External Descriptors Not available
Estructura 3D
Modelo de Estructura Química Interactiva





Objetivos asociados (humanos)
ADORA2A Tclin Adenosine receptor A2a (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
ADORA2B Tclin Adenosine receptor A2b (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
ADORA1 Tclin Adenosine receptor A1 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
ADORA1 Tclin Adenosine A1 receptor (17603 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADORA2A Tclin Adenosine A2a receptor (16305 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADORA2B Tclin Adenosine A2b receptor (7672 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADORA3 Tchem Adenosine A3 receptor (15931 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mecanismos de acción
Certificados (CoA, COO, BSE/TSE y tabla de análisis)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

8 results found

Lot NumberCertificate TypeFechaArticulo
L2313374Certificate of AnalysisNov 27, 2023 I414133
L2314344Certificate of AnalysisNov 27, 2023 I414133
L2314345Certificate of AnalysisNov 27, 2023 I414133
L2314346Certificate of AnalysisNov 27, 2023 I414133
L2314347Certificate of AnalysisNov 27, 2023 I414133
L2314348Certificate of AnalysisNov 27, 2023 I414133
L2314373Certificate of AnalysisNov 27, 2023 I414133
L2314375Certificate of AnalysisNov 27, 2023 I414133
Propiedades químicas y físicas
SolubilidadSolubility (25°C) In vitro DMSO: 63 mg/mL (199.53 mM); Ethanol: 4 mg/mL (12.66 mM); Water: Insoluble;
Peso molecular315.730 g/mol
XLogP32.600
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count6
Rotatable Bond Count2
Exact Mass315.069 Da
Monoisotopic Mass315.069 Da
Topological Polar Surface Area77.600 Ų
Heavy Atom Count22
Formal Charge0
Complexity366.000
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
The total count of all stereochemical bonds0
Covalently-Bonded Unit Count1
Calculadoras de soluciones
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