Imiloxan(RS-21361) - Moligand™,≥98% , Antagonist of α 2B-adrenoceptor, CAS No.81167-16-0, Antagonist of α 2B-adrenoceptor

CAS: 81167-16-0 Cat. No.: I611041 Peso molecular: 244.29
Disponible para pedir
GRADE & PURITY Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
Synonyms
NCGC00015570-04 | GNF-Pf-2156 | Tox21_110175_1 | Imiloxano [Spanish] | PDSP2_001483 | 1H-Imidazole, 2-[(2,3-dihydro-1,4-benzodioxin-2-yl)methyl]-1-ethyl- | Propyl 3,5-diiodo-4-oxo-1(4H)-pyridineacetate | (+-)-2-(1,4-Benzodioxan-2-ylmethyl)-1-ethylimidazol
Storage
Store at -20°C
Shipped In
Ice chest + Ice pads
 ·  off list, applied to all prices below.
Size
Estado
Price
Qty
1mg
I611041-1mg
8-12 wks(?) Production requires sourcing of materials. We appreciate your patience and understanding.
119,90US$
5mg
I611041-5mg
8-12 wks(?) Production requires sourcing of materials. We appreciate your patience and understanding.
369,90US$
25mg
I611041-25mg
8-12 wks(?) Production requires sourcing of materials. We appreciate your patience and understanding.
1.119,90US$
Enter a quantity for the sizes you want to add.
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Why this grade

Moligand™,≥98% Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

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Storage & shipping

Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.

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Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

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Literature proof

Cited in 3 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Specifications

Sinónimos
NCGC00015570-04 | GNF-Pf-2156 | Tox21_110175_1 | Imiloxano [Spanish] | PDSP2_001483 | 1H-Imidazole, 2-[(2, 3-dihydro-1, 4-benzodioxin-2-yl)methyl]-1-ethyl- | Propyl 3, 5-diiodo-4-oxo-1(4H)-pyridineacetate | (+-)-2-(1, 4-Benzodioxan-2-ylmethyl)-1-ethylimidazol
Especificaciones y pureza
Moligand™, ≥98%
Mecanismos bioquímicos y fisiológicos
Imiloxan (RS 21361) is a potent and selective alpha 2B-adrenoceptor antagonist. Imiloxan produces a dose-related reversal of Guanoxabenz-induced maximal mydriasis in male rats. Imiloxan has the potential for acute kidney injury research.
Condiciones de almacenamiento de almacenamiento
Store at -20°C
Enviado en
Ice chest + Ice pads
Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.
Grado
Moligand™
Tipo de acción
ANTAGONIST
Mecanismo de acción
Antagonist of α 2B-adrenoceptor
Pureza
≥98%
Nombres e identificadores
Sonrisas canónicasCCn1ccnc1CC1COc2c(O1)cccc2
IUPAC Name2-(2,3-dihydro-1,4-benzodioxin-2-ylmethyl)-1-ethylimidazole
InChIKeyUXABARREKCJULM-UHFFFAOYSA-N
INCHI1S/C14H16N2O2/c1-2-16-8-7-15-14(16)9-11-10-17-12-5-3-4-6-13(12)18-11/h3-8,11H,2,9-10H2,1H3
Isómeros SMILES CCN1C=CN=C1CC2COC3=CC=CC=C3O2
Peso molecular 244.29

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

KingdomOrganic compounds
SuperclassOrganoheterocyclic compounds
ClaseBenzodioxanes
SubclassBenzo-1,4-dioxanes
Intermediate Tree Nodes Not available
Direct ParentBenzo-1,4-dioxanes
Alternative Parents Alkyl aryl ethers  Para dioxins  N-substituted imidazoles  Benzenoids  Heteroaromatic compounds  Oxacyclic compounds  Azacyclic compounds  Organopnictogen compounds  Organonitrogen compounds  Hydrocarbon derivatives  
Molecular FrameworkAromatic heteropolycyclic compounds
Substituents Benzo-1,4-dioxane - Alkyl aryl ether - N-substituted imidazole - Para-dioxin - Benzenoid - Azole - Imidazole - Heteroaromatic compound - Ether - Azacycle - Oxacycle - Hydrocarbon derivative - Organooxygen compound - Organonitrogen compound - Organopnictogen compound - Organic oxygen compound - Organic nitrogen compound - Aromatic heteropolycyclic compound
DescripciónThis compound belongs to the class of organic compounds known as benzo-1,4-dioxanes. These are heterocyclic compounds containing a benzene ring fused to a 1,4-dioxane ring.
External Descriptors Not available
Estructura 3D
Modelo de Estructura Química Interactiva





Objetivos asociados (humanos)
ADRA2B Tclin Alpha-2B adrenergic receptor (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
DRD1 Tclin Dopamine D1 receptor (9720 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ABCB11 Tchem Bile salt export pump (2311 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
EHMT2 Tchem Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (93046 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PMP22 Tbio Peripheral myelin protein 22 (699 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CBX1 Tbio Chromobox protein homolog 1 (92434 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ATAD5 Tbio ATPase family AAA domain-containing protein 5 (122566 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Objetivos asociados (no humanos)
Hdac6 Histone deacetylase 6 (222 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
pfk 6-phospho-1-fructokinase (7870 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Nfe2l2 Nuclear factor erythroid 2-related factor 2 (214 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Adra1b Adrenergic receptor alpha-1 (5652 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Adra2c Adrenergic receptor alpha-2 (3313 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mecanismos de acción
Certificados (CoA, COO, BSE/TSE y tabla de análisis)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:
Propiedades químicas y físicas
Peso molecular244.290 g/mol
XLogP32.100
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count3
Rotatable Bond Count3
Exact Mass244.121 Da
Monoisotopic Mass244.121 Da
Topological Polar Surface Area36.300 Ų
Heavy Atom Count18
Formal Charge0
Complexity275.000
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
The total count of all stereochemical bonds0
Covalently-Bonded Unit Count1
Citations of This Product
Referencias
1. Yue Wang, Guojun Pan, Tingjie Huang, Tao Zhang, Jin Lin, Lubin Song, Guangshuo Zhou, Xiaoping Ma, Yanqing Ge, Yongyu Xu, Chunhao Yuan, Nan Zou.  (2023)  Exogenous tannic acid relieves imidacloprid-induced oxidative stress in tea tree by activating antioxidant responses and the flavonoid biosynthetic pathway.  ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,      [PMID:37820476] [10.1016/j.ecoenv.2023.115557]
2. Yong Yang, Xinxin Ma, Zifen Li, Yanru Wang, Chao Ju, Lidong Cao, Yongquan Zheng, Qingming Zhang.  (2023)  ZIF-8 and humic acid modified magnetic corn stalk biochar: An efficient, magnetically stable, and eco-friendly adsorbent for imidacloprid and thiamethoxam removal.  CHEMICAL ENGINEERING JOURNAL,      [PMID:] [10.1016/j.cej.2023.142788]
3. Chao Zhang, Huike Zhang, Xin Wan, Yue Xie, Michael J. Bentel, Zhanjiang Yu, Zhenguo Chen, Jiaan He, Junlang Li, Xuezhu Xiang, Xinzhi Wang, Zhaoli Wang, Guang-Guo Ying, Dionysios D. Dionysiou, Mingzhi Huang.  (2023)  Nitrogen-Doped Graphdiyne Nanotubes for Metal-Free Activation of Peroxymonosulfate and Enhanced Degradation of Recalcitrant Heterocyclic Contaminants.  ACS ES&T Engineering,      [PMID:] [10.1021/acsestengg.3c00009]
Calculadoras de soluciones
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