Ionomycin (Calcium salt) - ≥98%(HPLC) , CAS No.56092-82-1

CAS: 56092-82-1 Cat. No.: I133497 Peso molecular: 747.07 Beilstein Registry Number: 1416163 Número EC: 611-357-2

GRADE & PURITY ≥98%(HPLC)

Synonyms

calcium (4R,6S,8S,10Z,12R,14R,16E,18R,19R,20S,21S)-19,21-dihydroxy-22-((2S,2'R,5S,5'S)-5'-((R)-1-hydroxyethyl)-2,5'-dimethyloctahydro-[2,2'-bifuran]-5-yl)-4,6,8,12,14,18,20-heptamethyl-11-oxido-9-oxodocosa-10,16-dienoate | Ionomycin calcium salt from Stre

Storage

Store at -20°C,Argon charged

Shipped In

Ice chest + Ice pads

Descripción general

This product is a Ca2+ ionophore that has been shown to be more effective than A23187 as a mobile ion carrier for Ca2+ ; non-fluorescent; used to study Ca2+ transport across biological membranes; induces apoptotic degeneration of embryonic cortical neurons.
Ionomycin is more effectivethan A23187 as a Ca++ionophore; Ionomycin is used in research on Ca++ transport across biological membranes; Ionomycin induces apoptotic degeneration of embryonic cortical neurons.

Specifications

Sinónimos

calcium (4R, 6S, 8S, 10Z, 12R, 14R, 16E, 18R, 19R, 20S, 21S)-19, 21-dihydroxy-22-((2S, 2'R, 5S, 5'S)-5'-((R)-1-hydroxyethyl)-2, 5'-dimethyloctahydro-[2, 2'-bifuran]-5-yl)-4, 6, 8, 12, 14, 18, 20-heptamethyl-11-oxido-9-oxodocosa-10, 16-dienoate | Ionomycin calcium salt from Stre

Especificaciones y pureza

≥98%(HPLC)

Mecanismos bioquímicos y fisiológicos

Ca2+ ionophore that is more effective than A23187 as a mobile ion carrier for Ca2+; non-fluorescent; used to study Ca2+ transport across biological membranes; induces apoptotic degeneration of embryonic cortical neurons.Ca 2+ ionophore. Useful when calciu

Condiciones de almacenamiento de almacenamiento

Store at -20°C, Argon charged

Enviado en

Ice chest + Ice pads

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Tipo de acción

INHIBITOR

Nota

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Pureza

≥98%(HPLC)

Nombres e identificadores

• Sonrisas canónicas: CC(CCC(=O)[O-])CC(C)CC(C)C(=O)C=C(C(C)CC(C)CC=CC(C)C(C(C)C(CC1CCC(O1)(C)C2CCC(O2)(C)C(C)O)O)O)[O-].[Ca+2]
• IUPAC Name: calcium;(4R,6S,8S,10Z,12R,14R,16E,18R,19R,20S,21S)-19,21-dihydroxy-22-[(2S,5S)-5-[(2R,5S)-5-[(1R)-1-hydroxyethyl]-5-methyloxolan-2-yl]-5-methyloxolan-2-yl]-4,6,8,12,14,18,20-heptamethyl-11-oxido-9-oxodocosa-10,16-dienoate
• InChIKey: WKRWUYKLUMMAKG-WYGBAUISSA-L
• INCHI: 1S/C41H72O9.Ca/c1-25(21-29(5)34(43)24-35(44)30(6)22-27(3)20-26(2)14-15-38(46)47)12-11-13-28(4)39(48)31(7)36(45)23-33-16-18-41(10,49-33)37-17-19-40(9,50-37)32(8)42;/h11,13,24-33,36-37,39,42-43,45,48H,12,14-23H2,1-10H3,(H,46,47);/q;+2/p-2/b13-11+,34-24-;/t25-,26-,27+,28-,29-,30+,31+,32-,33+,36+,37-,39-,40+,41+;/m1./s1
• Isómeros SMILES: C[C@H](CCC(=O)[O-])C[C@H](C)C[C@H](C)C(=O)/C=C(/[C@H](C)C[C@H](C)C/C=C/[C@@H](C)[C@H]([C@@H](C)[C@H](C[C@@H]1CC[C@@](O1)(C)[C@H]2CC[C@@](O2)(C)[C@@H](C)O)O)O)\[O-].[Ca+2]
• WGK Alemania: 3
• RTECS: NO0650000
• Peso molecular: 747.07
• Beilstein: 1416163
• Reaxy-Rn: 33753162
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=33753162&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Lipids and lipid-like molecules
    • Clase Prenol lipids
      • Subclass Terpene glycosides

• Kingdom: Organic compounds
• Superclass: Lipids and lipid-like molecules
• Clase: Prenol lipids
• Subclass: Terpene glycosides
• Intermediate Tree Nodes: Not available
• Direct Parent: Diterpene glycosides
• Alternative Parents: Very long-chain fatty acids Diterpenoids Hydroxy fatty acids Unsaturated fatty acids Vinylogous acids Acryloyl compounds Oxolanes Enones Secondary alcohols Carboxylic acid salts Ketones Enolates Oxacyclic compounds Dialkyl ethers Carboxylic acids Monocarboxylic acids and derivatives Organic calcium salts Organic oxides Hydrocarbon derivatives Organic zwitterions Aldehydes
• Molecular Framework: Aliphatic heteromonocyclic compounds
• Substituents: Diterpene glycoside - Very long-chain fatty acid - Diterpenoid - Hydroxy fatty acid - Fatty acyl - Fatty acid - Unsaturated fatty acid - Acryloyl-group - Enone - Vinylogous acid - Alpha,beta-unsaturated ketone - Oxolane - Carboxylic acid salt - Ketone - Secondary alcohol - Carboxylic acid derivative - Organic calcium salt - Carboxylic acid - Dialkyl ether - Enolate - Oxacycle - Ether - Organoheterocyclic compound - Monocarboxylic acid or derivatives - Organic oxide - Hydrocarbon derivative - Carbonyl group - Organic oxygen compound - Alcohol - Aldehyde - Organic salt - Organooxygen compound - Organic zwitterion - Aliphatic heteromonocyclic compound
• Descripción: This compound belongs to the class of organic compounds known as diterpene glycosides. These are diterpenoids in which an isoprene unit is glycosylated.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Objetivos asociados (humanos)

THP-1 (11052 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Objetivos asociados (no humanos)

Trpa1 Transient receptor potential cation channel subfamily A member 1 (1003 Activities)

Discover Target: Trpa1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mecanismos de acción

Propiedades químicas y físicas

• Solubilidad: DMSO, Ethanol, Methanol
• Sensibilidad: Moisture & Light sensitive
• Punto de fusión (°C): 195°C-207°C
• Peso molecular: 747.100 g/mol
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 9
• Rotatable Bond Count: 21
• Exact Mass: 746.465 Da
• Monoisotopic Mass: 746.465 Da
• Topological Polar Surface Area: 159.000 Ų
• Heavy Atom Count: 51
• Formal Charge: 0
• Complexity: 1120.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 14
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 2
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 2
• Covalently-Bonded Unit Count: 2

XLogP3