≥98% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Information
IRAK4-IN-4 IRAK4-IN-4 (compound 15) is an inhibitor of interleukin-1 receptor–associated kinase 4 (IRAK4) and cyclic GMP-AMP synthase (cGAS) with IC50 of 2.8 nM and 2.1 nM, respectively.
Targets
cGAS (Cell-free assay); IRAK4 (Cell-free assay) 2.1 nM; 2.8 nM
| ALogP | 4.722 |
|---|---|
| hba_count | 3 |
| Enlace rotable | 4 |
| Pubchem Sid | 504773591 |
|---|---|
| Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/504773591 |
| Sonrisas canónicas | CC1=CC2=NC(=C(N2C=C1)C(=O)C(=O)C3=CC=CC=C3)C4=CC=CC=C4 |
| IUPAC Name | 1-(7-methyl-2-phenylimidazo[1,2-a]pyridin-3-yl)-2-phenylethane-1,2-dione |
| InChIKey | AHNNWZOVCRQAAH-UHFFFAOYSA-N |
| INCHI | 1S/C22H16N2O2/c1-15-12-13-24-18(14-15)23-19(16-8-4-2-5-9-16)20(24)22(26)21(25)17-10-6-3-7-11-17/h2-14H,1H3 |
| Peso molecular | 340.37 |
| Reaxy-Rn | 28981961 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=28981961&ln= |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →Taxonomy Tree
| Kingdom | Organic compounds |
|---|---|
| Superclass | Organoheterocyclic compounds |
| Clase | Azoles |
| Subclass | Imidazoles |
| Intermediate Tree Nodes | Substituted imidazoles |
| Direct Parent | Phenylimidazoles |
| Alternative Parents | Imidazopyridines Imidazo[1,2-a]pyridines Benzoyl derivatives Aryl ketones Dihydropyridines Carbonylimidazoles Alpha-diketones Alpha-branched alpha,beta-unsaturated ketones Heteroaromatic compounds Enones Acryloyl compounds Propargyl-type 1,3-dipolar organic compounds Carboximidamides Azacyclic compounds Amidines Organopnictogen compounds Organic oxides Hydrocarbon derivatives |
| Molecular Framework | Aromatic heteropolycyclic compounds |
| Substituents | 4-phenylimidazole - Imidazo[1,2-a]pyridine - Imidazopyridine - Aryl ketone - Benzoyl - Dihydropyridine - Imidazole-4-carbonyl group - Alpha-branched alpha,beta-unsaturated-ketone - Benzenoid - Pyridine - Monocyclic benzene moiety - Alpha-diketone - Heteroaromatic compound - Alpha,beta-unsaturated ketone - Enone - Acryloyl-group - Ketone - Azacycle - Organic 1,3-dipolar compound - Propargyl-type 1,3-dipolar organic compound - Carboximidamide - Amidine - Organic nitrogen compound - Organic oxygen compound - Organopnictogen compound - Organic oxide - Hydrocarbon derivative - Organooxygen compound - Organonitrogen compound - Aromatic heteropolycyclic compound |
| Descripción | This compound belongs to the class of organic compounds known as phenylimidazoles. These are polycyclic aromatic compounds containing a benzene ring linked to an imidazole ring through a CC or CN bond. |
| External Descriptors | Not available |
Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Fecha | Articulo |
|---|---|---|---|
 G2215608 | Certificate of Analysis | Apr 07, 2025 | I412539 |
| G2215609 | Certificate of Analysis | Apr 07, 2025 | I412539 |
| G2215610 | Certificate of Analysis | Apr 07, 2025 | I412539 |
| G2215612 | Certificate of Analysis | Apr 07, 2025 | I412539 |
| L2418314 | Certificate of Analysis | Jun 09, 2022 | I412539 |
| Solubilidad | Solubility (25°C) In vitro DMSO: 68 mg/mL (199.78 mM); Ethanol: 68 mg/mL (199.78 mM); Water: Insoluble; |
|---|---|
| DMSO (mg/ml) Solubilidad máxima | 68 |
| DMSO (mM) Solubilidad máxima | 199.782589534918 |
| Agua (mg/ml) Solubilidad máxima | ＜1 |
| Peso molecular | 340.400 g/mol |
| XLogP3 | 5.100 |
| Hydrogen Bond Donor Count | 0 |
| Hydrogen Bond Acceptor Count | 3 |
| Rotatable Bond Count | 4 |
| Exact Mass | 340.121 Da |
| Monoisotopic Mass | 340.121 Da |
| Topological Polar Surface Area | 51.400 Ų |
| Heavy Atom Count | 26 |
| Formal Charge | 0 |
| Complexity | 522.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 0 |
| Covalently-Bonded Unit Count | 1 |
