ISO-1 - Moligand™, 10mM in DMSO , CAS No.478336-92-4

CAS: 478336-92-4 Cat. No.: I408920 Peso molecular: 235.24

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

MIF Antagonist | 5-​Isoxazoleacetic acid, 4,​5-​dihydro-​3-​(4-​hydroxyphenyl)​-​, methyl ester

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Descripción general

Information

ISO-1 ISO-1 (MIF Antagonist) is an inhibitor of MIF (Macrophage migration inhibitory factor) D-dopachrome tautomerase activity with an IC50 of ~7 μM.
In vitro

ISO-1 significantly inhibits the cytokine activity in vitro. It inhibits tumor necrosis factor release from macrophages isolated from LPStreated wild type mice but has no effect on cytokine release from MIF-deficient macrophages.

In vivo

ISO-1 significantly increases the survival rate in severe sepsis induced by endotoxin or cecal ligation and puncture (CLP). It could prevent airway hyperresponsiveness (AHR) in mouse ovalbumin (OVA)-challenge models. ISO-1 attenuated ozone-induced cell recruitment, cytokine release and AHR in the mouse but did not affect measures of emphysema. ISO-1 protects photoreceptors and reduces gliosis in experimental retinal detachment.
Cell Data

cell lines：

Concentrations：1-100 μM

Incubation Time：30 min

Powder Purity:≥98%

Specifications

Sinónimos

MIF Antagonist | 5-​Isoxazoleacetic acid, 4, ​5-​dihydro-​3-​(4-​hydroxyphenyl)​-​, methyl ester

Especificaciones y pureza

Moligand™, 10mM in DMSO

Mecanismos bioquímicos y fisiológicos

ISO-1 (MIF Antagonist) is an inhibitor of MIF (Macrophage migration inhibitory factor) D-dopachrome tautomerase activity with an IC50 of ~7 μM.

Condiciones de almacenamiento de almacenamiento

Store at -80°C

Enviado en

Dry ice packs + Cold packs

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Grado

Moligand™

Tipo de acción

INHIBITOR

Nombres e identificadores

• Isómeros SMILES: COC(=O)CC1CC(=NO1)C2=CC=C(C=C2)O
• Peso molecular: 235.24
• Reaxy-Rn: 10343690
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=10343690&ln=

Propiedades químicas y físicas

• Punto de fusión (°C): 112.0 - 116.0 °C

Referencias

1. Chen Chuan-jun, Guo Ding-wen, Yuan Qing-yun, Zhuo You-qiong, Yang Shi-fen, Xu Hao-min, Wang You-rong, Guan Xiao-hui, Deng Ke-yu, Xin Hong-bo.  (2026)  MIF tautomerase inhibitor 4-IPP alleviates HFD-induced obesity by restoring CD137-mediated browning of white adipocytes in mice.  ACTA PHARMACOLOGICA SINICA,      [PMID:41741765] [10.1038/s41401-026-01755-3]