Determine the necessary mass, volume, or concentration for preparing a solution.
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Moligand™, ≥98% Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Protected from light,Room temperature Ships Normal Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 11 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Isonipecotic acid is an important reactant for the synthesis of alkyl piperidine and piperazine hydroxamic acids as HDAC inhibitors. It is also used in the synthesis of antibiotic nitroxoline derivatives for cathepsin B inhibition.
A HDAC inhibitor.
| Pubchem Sid | 488179794 |
|---|---|
| Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/488179794 |
| Sonrisas canónicas | C1CNCCC1C(=O)O |
| IUPAC Name | piperidine-4-carboxylic acid |
| InChIKey | SRJOCJYGOFTFLH-UHFFFAOYSA-N |
| INCHI | 1S/C6H11NO2/c8-6(9)5-1-3-7-4-2-5/h5,7H,1-4H2,(H,8,9) |
| Isómeros SMILES | C1CNCCC1C(=O)O |
| WGK Alemania | 3 |
| RTECS | NS5150000 |
| Peso molecular | 129.16 |
| Beilstein | 112553 |
| Reaxy-Rn | 112553 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=112553&ln= |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →Taxonomy Tree
| Kingdom | Organic compounds |
|---|---|
| Superclass | Organoheterocyclic compounds |
| Clase | Piperidines |
| Subclass | Piperidinecarboxylic acids and derivatives |
| Intermediate Tree Nodes | Not available |
| Direct Parent | Piperidinecarboxylic acids |
| Alternative Parents | Amino acids Monocarboxylic acids and derivatives Dialkylamines Carboxylic acids Azacyclic compounds Organopnictogen compounds Organic oxides Hydrocarbon derivatives Carbonyl compounds |
| Molecular Framework | Aliphatic heteromonocyclic compounds |
| Substituents | Piperidinecarboxylic acid - Amino acid or derivatives - Amino acid - Carboxylic acid derivative - Carboxylic acid - Secondary aliphatic amine - Monocarboxylic acid or derivatives - Azacycle - Secondary amine - Amine - Organooxygen compound - Organonitrogen compound - Hydrocarbon derivative - Organic oxide - Organopnictogen compound - Organic oxygen compound - Carbonyl group - Organic nitrogen compound - Aliphatic heteromonocyclic compound |
| Descripción | This compound belongs to the class of organic compounds known as piperidinecarboxylic acids. These are compounds containing a piperidine ring which bears a carboxylic acid group. |
| External Descriptors | Not available |
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Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Fecha | Articulo |
|---|---|---|---|
| Certificate of Analysis | Jun 27, 2024 | I109586 | |
| Certificate of Analysis | Jun 27, 2024 | I109586 | |
| Certificate of Analysis | Sep 08, 2023 | I109586 | |
| Certificate of Analysis | Jun 23, 2022 | I109586 | |
| Certificate of Analysis | Jun 22, 2022 | I109586 | |
| Certificate of Analysis | Mar 22, 2022 | I109586 | |
| Certificate of Analysis | Mar 22, 2022 | I109586 | |
| Certificate of Analysis | Mar 22, 2022 | I109586 | |
| Certificate of Analysis | Mar 22, 2022 | I109586 | |
| Certificate of Analysis | Mar 22, 2022 | I109586 | |
| Certificate of Analysis | Mar 22, 2022 | I109586 | |
| Certificate of Analysis | Mar 22, 2022 | I109586 | |
| Certificate of Analysis | Mar 22, 2022 | I109586 |
| Solubilidad | Solubility in Water:very faint turbidity |
|---|---|
| Sensibilidad | Light sensitive. |
| Punto de fusión (°C) | 300°C |
| Peso molecular | 129.160 g/mol |
| XLogP3 | -3.000 |
| Hydrogen Bond Donor Count | 2 |
| Hydrogen Bond Acceptor Count | 3 |
| Rotatable Bond Count | 1 |
| Exact Mass | 129.079 Da |
| Monoisotopic Mass | 129.079 Da |
| Topological Polar Surface Area | 49.300 Ų |
| Heavy Atom Count | 9 |
| Formal Charge | 0 |
| Complexity | 108.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 0 |
| Covalently-Bonded Unit Count | 1 |
| 1. Junjian Xie, Jun Zhang, Xiaoyu Wang, Jiawei Xie, Bo Yang, Yuxuan Liang, Ji-Jun Zou, Qiuyu Zhang. (2023) Synthesis of JP-10 analogues high-density fuels via one-pot Diels-Alder/hydrodeoxygenation reaction. FUEL, [PMID:] [10.1016/j.fuel.2023.130738] |
| 2. Xianwei Li, Zhenqian Wu, Xudong Ma, Ling Xin, Xiao Yu, Yong Liu. (2023) MOF-derived crystalline carbon with graphite-like crystal: A high initial coulombic efficiency, low potential and large capacity anode for Na-ion batteries. CARBON, [PMID:] [10.1016/j.carbon.2023.03.020] |
| 3. Junjian Xie, Yuxuan Liang, Bo Yang, Jun Zhang, Jiawei Xie, Ji-Jun Zou, Qiuyu Zhang. (2023) Photosensitized Conia reaction directed synthesis of high-performance asymmetric polycyclic hydrocarbons from biomass-derived ketones and petroleum-derived norbornene. FUEL, [PMID:] [10.1016/j.fuel.2023.127539] |
| 4. Dafu Cao, Fei Yang, Weibing Sheng, Yufeng Zhou, Xixing Zhou, Yaguang Lu, Fengmin Nie, Nanwen Li, Li Pan, Yuesheng Li. (2021) Polynorbornene-based anion exchange membranes with hydrophobic large steric hindrance arylene substituent. JOURNAL OF MEMBRANE SCIENCE, [PMID:] [10.1016/j.memsci.2021.119938] |
| 5. Junjie Zhou, Ning Li, Jialu Shen, Xu Meng, Xiang Liu. (2021) Palladium on carbon as an efficient, durable and economical catalyst for the alcoholysis of B2pin2. INORGANIC CHEMISTRY COMMUNICATIONS, [PMID:] [10.1016/j.inoche.2021.108732] |
| 6. Zhou Junjie, Huang Yu, Shen Jialu, Liu Xiang. (2021) Pd/C-Catalyzed H2 Evolution from Tetrahydroxydiboron Hydrolysis. CATALYSIS LETTERS, 151 (10): (3004-3010). [PMID:] [10.1007/s10562-021-03547-2] |
| 7. Yingpeng Huo, Jiwen Hu, Yuanyuan Tu, Zhenzhu Huang, Shudong Lin, Yangfei Hu, Chao Feng. (2020) Platinum-Imidazolyl Schiff Base Complexes Immobilized in Periodic Mesoporous Organosilica Frameworks as Catalysts for Hydrosilylation. APPLIED ORGANOMETALLIC CHEMISTRY, 34 (8): (e5697). [PMID:] [10.1002/aoc.5697] |
| 8. Junjian Xie, Xiangwen Zhang, Chengxiang Shi, Lun Pan, Fang Hou, Genkuo Nie, Jiawei Xie, Qing Liu, Ji-Jun Zou. (2019) Self-photosensitized [2 + 2] cycloaddition for synthesis of high-energy-density fuels. Sustainable Energy & Fuels, 4 (2): (911-920). [PMID:] [10.1039/C9SE00863B] |
| 9. Qingshan Zhao, Dejian Xu, Libo Wang, Shihao Cui, Qinlian Liu, Xuan Han, Zhiyuan Wang, Hui Ning, Mingbo Wu. (2025) A core-shell confinement strategy towards single-atom Fe-N/S-C bifunctional catalyst for selective nitroarene reduction and olefin epoxidation. JOURNAL OF ALLOYS AND COMPOUNDS, [PMID:] [10.1016/j.jallcom.2025.178488] |
| 10. Long Jiang, Yaojie Liu, Lulu Zhang, Liang Qin, Zongjiang Yu, Mo Xian, Weizhi Sun, Chao Xu. (2024) Efficient capture of Pd by multidentate S/N-containing group modified materials: An important piece of puzzle for electron transfer ratio ligand design. CHEMICAL ENGINEERING JOURNAL, [PMID:] [10.1016/j.cej.2024.151680] |
| 11. Xinyue Zhang, Yuan Yao, Yingying Cao, Xin Tan, Xiaomin Fang, Yanqiang Zhang. (2025) Enhanced Cyclopropanation of Norbornene as a High-Energy Fuel by Pd Single-Site Catalysts. INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH, [PMID:] [10.1021/acs.iecr.5c01267] |
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