Isosorbide - 10mM in DMSO , CAS No.652-67-5

CAS: 652-67-5 Cat. No.: I425302 Peso molecular: 146.14 Beilstein Registry Number: 80510 Número EC: 211-492-3
Disponible para pedir
GRADE & PURITY 10mM in DMSO
Synonyms
1,4:3,6-Dianhydro-D-sorbitol | 1,4:3,6-Dianhydrosorbitol | BIDD:GT0695 | NSC40725 | NSC-40725 | D-Glucitol, 1,4:3,6-dianhydro- | EN300-170910 | D00347 | Dianhydro-D-glucitol | 1,4-Dianhydrosorbitol | Isosorbida (INN-Spanish) | Tox21_111861 | Glucitol, 1,4
Storage
Store at -80°C
Shipped In
Dry ice packs + Cold packs
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Size
Estado
Price
Qty
1ml
I425302-1ml
2
27,90US$
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Why this grade

10mM in DMSO for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

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Storage & shipping

Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.

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Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

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Literature proof

Cited in 33 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Specifications

Sinónimos
1, 4:3, 6-Dianhydro-D-sorbitol | 1, 4:3, 6-Dianhydrosorbitol | BIDD:GT0695 | NSC40725 | NSC-40725 | D-Glucitol, 1, 4:3, 6-dianhydro- | EN300-170910 | D00347 | Dianhydro-D-glucitol | 1, 4-Dianhydrosorbitol | Isosorbida (INN-Spanish) | Tox21_111861 | Glucitol, 1, 4
Especificaciones y pureza
10mM in DMSO
Mecanismos bioquímicos y fisiológicos
Osmotic diuretic agent. Nitric oxide donor. Shows vasodilatory, antihypertensive and diuretic effects in vivo. Orally active.
Condiciones de almacenamiento de almacenamiento
Store at -80°C
Enviado en
Dry ice packs + Cold packs
Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.
Nombres e identificadores
Sonrisas canónicasC1C(C2C(O1)C(CO2)O)O
IUPAC Name(3S,3aR,6R,6aR)-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-3,6-diol
InChIKeyKLDXJTOLSGUMSJ-JGWLITMVSA-N
INCHI1S/C6H10O4/c7-3-1-9-6-4(8)2-10-5(3)6/h3-8H,1-2H2/t3-,4+,5-,6-/m1/s1
Isómeros SMILES C1[C@H]([C@@H]2[C@H](O1)[C@H](CO2)O)O
WGK Alemania 2
RTECS LZ4380000
Peso molecular 146.14
Beilstein 80510
Reaxy-Rn 80508
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=80508&ln=

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

KingdomOrganic compounds
SuperclassOrganoheterocyclic compounds
ClaseFurofurans
SubclassIsosorbides
Intermediate Tree Nodes Not available
Direct ParentIsosorbides
Alternative Parents Tetrahydrofurans  Secondary alcohols  Oxacyclic compounds  Dialkyl ethers  Hydrocarbon derivatives  
Molecular FrameworkAliphatic heteropolycyclic compounds
Substituents Isosorbide - Tetrahydrofuran - Secondary alcohol - Oxacycle - Ether - Dialkyl ether - Organic oxygen compound - Hydrocarbon derivative - Organooxygen compound - Alcohol - Aliphatic heteropolycyclic compound
DescripciónThis compound belongs to the class of organic compounds known as isosorbides. These are organic polycyclic compounds containing an isosorbide(1,4-Dianhydrosorbitol) moiety, which consists of two -oxolan-3-ol rings.
External Descriptors Not available
Estructura 3D
Modelo de Estructura Química Interactiva





Objetivos asociados (humanos)
THRB Tclin Thyroid hormone receptor beta-1 (7926 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
EHMT2 Tchem Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (93046 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PMP22 Tbio Peripheral myelin protein 22 (699 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Objetivos asociados (no humanos)
Hdac6 Histone deacetylase 6 (222 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GCN5 Histone acetyltransferase GCN5 (89 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
FTL Ferritin light chain (43324 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mecanismos de acción
Certificados (CoA, COO, BSE/TSE y tabla de análisis)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:
Propiedades químicas y físicas
SensibilidadMoisture sensitive
Rotación específica [α]45° (C=5,H2O)
Punto de ebullición (°C)175°C/2mmHg
Punto de fusión (°C)58-63℃
Peso molecular146.140 g/mol
XLogP3-1.400
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count0
Exact Mass146.058 Da
Monoisotopic Mass146.058 Da
Topological Polar Surface Area58.900 Ų
Heavy Atom Count10
Formal Charge0
Complexity122.000
Isotope Atom Count0
Defined Atom Stereocenter Count4
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
The total count of all stereochemical bonds0
Covalently-Bonded Unit Count1
Preguntas frecuentes y artículos
Citations of This Product
Referencias
1. Fukai Chu, Wei Wang, Yifan Zhou, Zhoumei Xu, Bin Zou, Xin Jiang, Yandong Hu, Weizhao Hu.  (2023)  Fully bio-based and intrinsically flame retardant unsaturated polyester cross-linked with isosorbide-based diluents.  CHEMOSPHERE,      [PMID:37820874] [10.1016/j.chemosphere.2023.140371]
2. Feng Caixing, Ma Haihong, Ren Fengmei, Zhou Zhengfa, Xu Weibing.  (2023)  Synthesis of fully bio-based branched unsaturated polyester oligomers and UV curing coatings.  Journal of Coatings Technology and Research,  20  (5): (1747-1758).  [PMID:] [10.1007/s11998-023-00778-3]
3. Danping Yuan, Fukui Xiao, Ning Zhao, Cunbao Deng, Xin Huang, Hao Zhang, Qianmin Yang, Yonggang Qiao.  (2023)  Mesoporous poly(ionic liquid) solid acid for sequential dehydration of sorbitol to isosorbide.  CHEMICAL ENGINEERING JOURNAL,      [PMID:] [10.1016/j.cej.2023.141780]
4. Jiaying Gu, Ming Liu, Lin Li, Lulu Zhou, Lei He, Weijun Deng, Jing Hu.  (2023)  Osmanthus fragrance polyurethane/silk fibroin-based double-shell microcapsules for aromatic leather with sustained release fragrance.  FLAVOUR AND FRAGRANCE JOURNAL,  38  (2): (73-82).  [PMID:] [10.1002/ffj.3727]
5. Yinglu Sun, Xinxin Tian, Haopu Xie, Biru Shi, Jiahui Zhong, Xiangdong Liu, Yuming Yang.  (2022)  Reprocessable and degradable bio-based polyurethane by molecular design engineering with extraordinary mechanical properties for recycling carbon fiber.  POLYMER,      [PMID:] [10.1016/j.polymer.2022.125313]
6. Yong Li, Jiehao Qu, Zenghui Dai, Junyi Jiang, Jiajia Fu, Feiya Fu, Xiangdong Liu.  (2022)  Highly Bio-Based Unsaturated Polyester Resins with Improved Performance by Incorporating Isosorbide into the Polyester Prepolymer.  MACROMOLECULAR MATERIALS AND ENGINEERING,  307  (9): (2200203).  [PMID:] [10.1002/mame.202200203]
7. Xin Wang, Haoxin Niu, Wenwen Guo, Lei Song, Yuan Hu.  (2021)  Renewable isosorbide-derived poly(phosphoester) for simultaneously enhanced flame-retardancy and mechanical property of polylactide.  Progress in Natural Science-Materials International,      [PMID:] [10.1016/j.pnsc.2021.06.004]
8. Yuchao Wu, Mingen Fei, Tingting Chen, Renhui Qiu, Wendi Liu.  (2021)  Fabrication of degradable and high glass-transition temperature thermosets from palm oil and isosorbide for fiber-reinforced composites.  INDUSTRIAL CROPS AND PRODUCTS,      [PMID:] [10.1016/j.indcrop.2021.113744]
9. Weiwei Wang, Zifeng Yang, Yaqin Zhang, Hongyan He, Wenjuan Fang, Zhencai Zhang, Fei Xu.  (2021)  A paradigm for the efficient synthesis of bio-based polycarbonate with deep eutectic solvents as catalysts by inhibiting the degradation of molecular chains.  GREEN CHEMISTRY,  23  (11): (4134-4143).  [PMID:] [10.1039/D1GC01150B]
10. Xiaodong Liu, Xiaohao Liu, Ning Li, Peiyong Ma, Ying Zhang.  (2021)  Direct synthesis of hexitols from microcrystalline cellulose and birch over zirconium(IV) phosphate supported nickel catalysts and the mechanism study.  GREEN CHEMISTRY,  23  (3): (1353-1360).  [PMID:] [10.1039/D0GC03745A]
11. Zifeng Yang, Lei Liu, Hongzhe An, Chenhao Li, Zhencai Zhang, Wenjuan Fang, Fei Xu, Suojiang Zhang.  (2020)  Cost-Effective Synthesis of High Molecular Weight Biobased Polycarbonate via Melt Polymerization of Isosorbide and Dimethyl Carbonate.  ACS Sustainable Chemistry & Engineering,      [PMID:] [10.1021/acssuschemeng.0c00430]
12. Lele Jin, Wenzhi Li, Qiying Liu, Longlong Ma, Chao Hu, Ajibola T. Ogunbiyi, Mingwei Wu, Qi Zhang.  (2019)  High performance of Mo-promoted Ir/SiO2 catalysts combined with HZSM-5 toward the conversion of cellulose to C5/C6 alkanes.  BIORESOURCE TECHNOLOGY,      [PMID:31796376] [10.1016/j.biortech.2019.122492]
13. Wanming Wang, Feng Wu, Huanjun Lu, Xiaohong Li, Xiaoming Yang, Yingfeng Tu.  (2019)  A Cascade Polymerization Method for the Property Modification of Poly(butylene terephthalate) by the Incorporation of Isosorbide.  ACS Applied Polymer Materials,      [PMID:] [10.1021/acsapm.9b00332]
14. Danping Yuan, Ning Zhao, Yanxia Wang, Keng Xuan, Feng Li, Yanfeng Pu, Feng Wang, Lei Li, Fukui Xiao.  (2018)  Dehydration of sorbitol to isosorbide over hydrophobic polymer-based solid acid.  APPLIED CATALYSIS B-ENVIRONMENTAL,      [PMID:] [10.1016/j.apcatb.2018.08.036]
15. Xinyi Gao, Jie Jiang, Junyao Shen, Shaoliang Lin, Ling Zhao, Zhenhao Xi.  (2024)  Alkali Metal/Quaternary Ammonium Salt Synergistic Catalytic System for the Efficient Synthesis of Biobased Poly(Isosorbide Carbonate).  INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH,      [PMID:] [10.1021/acs.iecr.4c01174]
16. Yujia Xie, Hailin Zhuang, Weibing Pei, Jiaming Guo, Yan Ma, Lingqiang Kong, Yuhui Ao, Liu Liu, Yu Liu.  (2024)  Bio-based semi-aromatic waterborne PIEK-C sizing agent to construct a robust interface for CF/PEEK composites.  POLYMER COMPOSITES,      [PMID:] [10.1002/pc.28745]
17. Yuehong Zhang, Qinyang Lei, Shutong Zhang, Langlang Dai, Bin Lyu, Leipeng Liu.  (2024)  Biobased Unsaturated Polyester Thermosets from Castor Oil and Isosorbide with Life Cycle Assessment.  ACS Sustainable Chemistry & Engineering,      [PMID:] [10.1021/acssuschemeng.4c07624]
18. Dan Li, Youbing Li, Yu Zhang, Yunsheng Xu, Xianming Zhang, Minna Hakkarainen.  (2025)  Designing Biobased Poly(ethylene-co-isosorbide terephthalate) Copolyesters with Tunable Properties and Degradability.  BIOMACROMOLECULES,      [PMID:40056101] [10.1021/acs.biomac.4c01630]
19. Dechang Cheng, Zhihong Ma, Ziyang Liu, Xiaohui Liu, Tao Liu, Weizhen Sun, Ling Zhao.  (2024)  Experiments and kinetic modeling of the sorbitol dehydration to isosorbide catalyzed by sulfuric acid under conditions of non-constant volume.  CHINESE JOURNAL OF CHEMICAL ENGINEERING,      [PMID:] [10.1016/j.cjche.2024.05.024]
20. Yiwen Zhang, Chenhao Li, Hao Wang, Zhao Yang, Wentao Zhang, Zhencai Zhang, Ruixia Liu, Fei Xu.  (2024)  Facile fabrication of hemicrystalline bio-based polycarbonate with superhydrophobic and high transmittance.  POLYMER,      [PMID:] [10.1016/j.polymer.2024.127729]
21. Xindi Feng, Dian Jin, Youcai Zhu, Jiale Peng, Yue Mu, Li Sun, Zuoxiang Zeng, Zhen Liu.  (2024)  Insights into the Role of Deep Eutectic Solvents in Sorbitol Dehydration: A Combined Experimental and Molecular Dynamics Study.  ACS Sustainable Chemistry & Engineering,      [PMID:] [10.1021/acssuschemeng.4c07461]
22. Shimin Geng, Zhen Huang, Yizhen Chen, Ying Li, Liyuan Zhang, Mingen Fei, Renhui Qiu, Wendi Liu.  (2024)  Polyurethane Acrylate Covalent Adaptable Networks Based on the Autocatalytic Effect of Palm Oil-Based Diol.  ACS Applied Polymer Materials,      [PMID:] [10.1021/acsapm.4c02964]
23. Yilin Shi, Jinhai Yang, Jiong Guo, Shiwei Wang, Danping Yuan, Ning Zhao, Fukui Xiao, Jianfeng Gao.  (2024)  Preparation of isosorbide by dehydration of sorbitol on hierarchical Beta zeolites under solvent-free conditions.  MICROPOROUS AND MESOPOROUS MATERIALS,      [PMID:] [10.1016/j.micromeso.2024.113009]
24. Meng Wu, Yingying Han, Hui You, Zhiwei Yang, Weihua Xu, Shijing Yan, Fang Wu, Taotao Fan, Jun Du.  (2025)  Synergistic enzyme/acid-degradable PCL-based polyurethanes with enhanced biocompatibility and shape memory properties.  EUROPEAN POLYMER JOURNAL,      [PMID:] [10.1016/j.eurpolymj.2025.114313]
25. Zhang Mengyi, Cheng Zhengzai, Yang Mian, Yu Qianwen, Tan Zhiping, Wandji Djouonkep Lesly Dasilva, Cheng Junpeng, Liu Panpan, Ding Ling, Gauthier Mario.  (2025)  Synthesis and Characterization of Poly(1,4-butylene 2,5-furandicarboxylate-co-isosorbide 2,5-furandicarboxylate).  JOURNAL OF WUHAN UNIVERSITY OF TECHNOLOGY-MATERIALS SCIENCE EDITION,  40  (2): (582-588).  [PMID:] [10.1007/s11595-025-3092-x]
26. Jiao Li, Shuai Tang, Yonglai Lu, Zhao Wang, Liqun Zhang.  (2025)  Design and Synthesis of Biobased, Biodegradable Polyester for Chewing Gum.  MACROMOLECULAR RAPID COMMUNICATIONS,      [PMID:40320751] [10.1002/marc.202500262]
27. Weiqi Chen, Han Hu, Li Cai, Hanxu Zhu, Qingyang Luan, Qi Jiang, Peng Liang, Jie Feng, Jinggang Wang, Jin Zhu.  (2025)  From waste to value: Scalable, one-pot upcycling of PET into high-performance copolyesters via hydroxy transesterification.  CHEMICAL ENGINEERING JOURNAL,      [PMID:] [10.1016/j.cej.2025.170039]
28. Jiaqi Yang, Guihua Zhang, Yanghuan Xing, Bixing Gao, Hua Du, Guihua Jiang.  (2025)  Development and optimization of green extraction of naringin in Citrus grandis ‘Tomentosa’ using natural deep eutectic solvents (NADES) and investigation of lung cancer therapeutics mechanisms.  RSC Advances,  15  (51): (44049-44060).  [PMID:41229959] [10.1039/D5RA07966G]
29. Xue Wang, Yu Cui, Chen Liu, Xianqiang Zeng, Yan Cao, Huijuan Zhang, Peng He, Huiquan Li, Liguo Wang.  (2025)  Recyclable, shape-memory and transparent bio-based thermoplastic polyurethane with exceptional mechanical properties.  POLYMER,      [PMID:] [10.1016/j.polymer.2025.129476]
30. Kexin Chang, Ruixia Duan, Suqin He, Hao Liu, Miao Ming Huang, Xu Wanlin, Chengshen Zhu, Zhe Chu, Tao Li, Wentao Liu.  (2025)  Epoxide Isosorbate Oleic Acid as a Sustainable PVC Plasticizer: Synthesis, Performance and Cytocompatibility.  GREEN CHEMISTRY,      [PMID:] [10.1039/D5GC02330K]
31. Cong Liu, Xiaolong Miao, Dihang Zhou, Hongxing Wang.  (2026)  High selectivity continuous production of isosorbide from sorbitol via reactive distillation.  CHEMICAL ENGINEERING RESEARCH & DESIGN,      [PMID:] [10.1016/j.cherd.2026.02.020]
32. Jianjun Li, Deyu Niu, Weijun Yang, Pengwu Xu, Piming Ma.  (2026)  A New Structure of High-Performance Isosorbide-Based Polyester-Polycarbonates and Its Mechanical Behavior.  MACROMOLECULES,      [PMID:] [10.1021/acs.macromol.5c03140]
33. Shijing Yan, Yingying Han, Meng Wu, Zhiwei Yang, Hui You, Weihua Xu, Jun Du, Cailiu Yin.  (2026)  From Soft-Segment Engineering to Multifunctional Performance: A Study on Fully Degradable Poly(butylene adipate)-Based Polyurethanes.  MACROMOLECULES,      [PMID:] [10.1021/acs.macromol.6c00262]
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