Isotretinoin - Moligand™, 10mM in DMSO , Retinoic acid receptor agonist, CAS No.4759-48-2, Retinoic acid receptor agonist

CAS: 4759-48-2 Cat. No.: I408672 Peso molecular: 300.44 Beilstein Registry Number: 9(4)2388 Número EC: 225-296-0

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

13-cis retinoic acid | (2Z,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-enyl)nona-2,4,6,8-tetraenoic acid

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Descripción general

Information

Isotretinoin Isotretinoin (13-cis retinoic acid) was developed to be used as a chemotherapy medication for the treatment of brain cancer, pancreatic cancer and more.
In vitro

Isotretinoin directly interferes with the development of cranial neural crest cells. Isotretinoin selectively affects neural crest cells by decreasing their cell-substratum adhesion.

In vivo

Isotretinoin (500 ng/mL) and its main metabolite in the human, 4-oxo-isotretinoin, induce malformations similar to those seen in vivo. Isotretinoin impairs explicit memory in Stage 2, but retention tests one month after Isotretinoin exposure ended, indicated recovery from this explicit memory impairment and evidence of enhanced implicit memory in the 10 mg and 15 mg ISO rats. Isotretinoin slows the recovery of rod signaling after exposure to an intense bleaching light, and that rhodopsin regeneration is markedly slowed. Isotretinoin is also found to protect rat photoreceptors from light-induced damage. Isotretinoin blocks the formation of A2E biochemically and the accumulation of lipofuscin pigments by electron microscopy. Isotretinoin also blocks the slower, age-dependent accumulation of lipofuscin in wild-type mice.
Cell Data

cell lines：Ba/F3 cells

Concentrations：

Incubation Time：

Powder Purity:≥95%

Specifications

Sinónimos

13-cis retinoic acid | (2Z, 4E, 6E, 8E)-3, 7-dimethyl-9-(2, 6, 6-trimethylcyclohex-1-enyl)nona-2, 4, 6, 8-tetraenoic acid

Especificaciones y pureza

Moligand™, 10mM in DMSO

Mecanismos bioquímicos y fisiológicos

Isotretinoin (13-cis retinoic acid) was developed to be used as a chemotherapy medication for the treatment of brain cancer, pancreatic cancer and more.

Condiciones de almacenamiento de almacenamiento

Store at -80°C

Enviado en

Dry ice packs + Cold packs

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Grado

Moligand™

Tipo de acción

AGONIST

Mecanismo de acción

Retinoic acid receptor agonist

Propiedades del producto

• ALogP: 6.3

Nombres e identificadores

• Isómeros SMILES: CC1=C(C(CCC1)(C)C)/C=C/C(=C/C=C/C(=C\C(=O)O)/C)/C
• WGK Alemania: 3
• RTECS: VH6440000
• Peso molecular: 300.44
• Beilstein: 9(4)2388
• Reaxy-Rn: 2508066
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=2508066&ln=

Objetivos asociados (humanos)

OR51E2 Tchem Olfactory receptor 51E2 (0 Activities)

Discover Target: OR51E2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Propiedades químicas y físicas

• Punto de fusión (°C): 175°C

Referencias

1. Peng Zhang, Lei Tian, Jiayu Bao, Shang Li, Ao Li, Ya Wen, Jingyi Wang, Ying Jie.  (2022)  Isotretinoin Impairs the Secretory Function of Meibomian Gland Via the PPARγ Signaling Pathway.  INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE,  63  (3): (29-29).  [PMID:35353124] [10.1167/iovs.63.3.29]

2. Jinshuang Wang, Qin Ye, Ningxiang Yu, Weiwei Huan, Jingliang Sun, Xiaohua Nie, Xianghe Meng.  (2021)  Preparation of multiresponsive hydrophilic molecularly imprinted microspheres for rapid separation of gardenia yellow and geniposide from gardenia fruit.  FOOD CHEMISTRY,      [PMID:34823938] [10.1016/j.foodchem.2021.131610]

3. Shungen Huang, Xian Yang, Yajuan Gao, Haoying Huang, Tuanwei Li, Meng Li, Feng Wu, Hongcao Yang, Chunyan Li.  (2024)  Multifunctional nano co-delivery system for efficiently eliminating neuroblastoma by overcoming cancer heterogeneity.  Biomedical Materials,  19  (6): (065033).  [PMID:39419089] [10.1088/1748-605X/ad8826]