GRADE & PURITY 10mM in DMSO

Synonyms

N-cyclopropyl-5-(2-thienyl)-3-isoxazolecarboxamide

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Descripción general

Information

Isoxazole 9 (ISX-9) Isoxazole 9 (Isx-9) is a synthetic promotor of adult neurogenesis by triggering neuronal differentiation of adult neural stem/precursor cells (NSPCs). Isoxazole 9 (Isx-9) activates multiple pathways including TGF-β induced epithelial
In vitro

In NSPCs, isoxazole 9 increases cell number, and promotes cell differentiation. In OPCs, isoxazole 9 induces cell damage. In outgrowth EPCs, isoxazole 9 decreases tube formation without effect on early EPCs.

In vivo

In mice, isoxazole 9 (20 mg/kg, i.p.) crosses the BBB and increases proliferation of neuroblasts and neurogenesis via Mef2-specific mechanisms in the hippocampal SGZ. Isoxazole 9 (20 mg/kg, i.p.) also increases differentiation and dendritic complexity of immature neurons and improves memory. In MWM, isoxazole 9 improves spatial memory.
Cell Data

cell lines：MKN45, EBC-1, Hs746T, SNU-5, A549, SNU-1 and MKN74

Concentrations：~50 μM

Incubation Time：48 h

Powder Purity:≥98%

Specifications

Sinónimos

N-cyclopropyl-5-(2-thienyl)-3-isoxazolecarboxamide

Especificaciones y pureza

10mM in DMSO

Mecanismos bioquímicos y fisiológicos

Isoxazole 9 (Isx-9) is a synthetic promotor of adult neurogenesis by triggering neuronal differentiation of adult neural stem/precursor cells (NSPCs). Isoxazole 9 (Isx-9) activates multiple pathways including TGF-β induced epithelial–mesenchymal transitio

Condiciones de almacenamiento de almacenamiento

Store at -80°C

Enviado en

Dry ice packs + Cold packs

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Tipo de acción

ACTIVATOR

Nombres e identificadores

• Isómeros SMILES: C1CC1NC(=O)C2=NOC(=C2)C3=CC=CS3
• Peso molecular: 234.27
• Reaxy-Rn: 18935384
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=18935384&ln=