Jaspamycin - ≥98% , CAS No.22242-96-2

CAS: 22242-96-2 Cat. No.: J647143 Peso molecular: 292.25 PubChem CID: 136670059

GRADE & PURITY ≥98%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Descripción general

Jaspamycin (7-CN-7-C-Ino) is a potent activator of PKA , binding to the R site (PKAR), with an EC 50 of 6.5 nM and K d of 8 nM in Trypanosoma brucei . Jaspamycin (7-CN-7-C-Ino) does not bind with purified human PKARIα. Anti-parasite activity

Form:Solid

IC50& Target:Trypanosoma brucei PKAR(199-499) 6.5 nM (EC 50 ) Trypanosoma Trypanosoma brucei PKA holoenzyme 8 nM (Kd)

Specifications

Especificaciones y pureza

≥98%

Mecanismos bioquímicos y fisiológicos

Jaspamycin (7-CN-7-C-Ino) is a potent activator of PKA , binding to the R site (PKAR), with an EC 50 of 6.5 nM and K d of 8 nM in Trypanosoma brucei . Jaspamycin (7-CN-7-C-Ino) does not bind with purified human PKARIα. Anti-parasite activity.

Condiciones de almacenamiento de almacenamiento

Store at -20°C

Enviado en

Ice chest + Ice pads

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Tipo de acción

INHIBITOR

Pureza

≥98%

Nombres e identificadores

• Sonrisas canónicas: C1=C(C2=C(N1C3C(C(C(O3)CO)O)O)N=CNC2=O)C#N
• IUPAC Name: 7-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-oxo-3H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile
• InChIKey: SKDKFLFSBDYEDO-WOUKDFQISA-N
• INCHI: 1S/C12H12N4O5/c13-1-5-2-16(10-7(5)11(20)15-4-14-10)12-9(19)8(18)6(3-17)21-12/h2,4,6,8-9,12,17-19H,3H2,(H,14,15,20)/t6-,8-,9-,12-/m1/s1
• Isómeros SMILES: C1=C(C2=C(N1[C@H]3[C@@H]([C@@H]([C@H](O3)CO)O)O)N=CNC2=O)C#N
• PubChem CID: 136670059
• Peso molecular: 292.25

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Nucleosides, nucleotides, and analogues
    • Clase Pyrrolopyrimidine nucleosides and nucleotides

• Kingdom: Organic compounds
• Superclass: Nucleosides, nucleotides, and analogues
• Clase: Pyrrolopyrimidine nucleosides and nucleotides
• Subclass: Not available
• Intermediate Tree Nodes: Not available
• Direct Parent: Pyrrolopyrimidine nucleosides and nucleotides
• Alternative Parents: Glycosylamines Pentoses Pyrrolo[2,3-d]pyrimidines Pyrimidones Substituted pyrroles Vinylogous amides Heteroaromatic compounds Oxolanes 1,2-diols Secondary alcohols Oxacyclic compounds Nitriles Azacyclic compounds Organic oxides Hydrocarbon derivatives Primary alcohols
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Pyrrolopyrimidine ribonucleoside - Glycosyl compound - N-glycosyl compound - Pentose monosaccharide - Pyrrolo[2,3-d]pyrimidine - Pyrrolopyrimidine - Pyrimidone - Monosaccharide - Pyrimidine - Substituted pyrrole - Oxolane - Heteroaromatic compound - Vinylogous amide - Pyrrole - 1,2-diol - Secondary alcohol - Carbonitrile - Nitrile - Oxacycle - Azacycle - Organoheterocyclic compound - Organooxygen compound - Organonitrogen compound - Alcohol - Organic nitrogen compound - Organic oxide - Hydrocarbon derivative - Primary alcohol - Organic oxygen compound - Cyanide - Aromatic heteropolycyclic compound
• Descripción: This compound belongs to the class of organic compounds known as pyrrolopyrimidine nucleosides and nucleotides. These are nucleoside derivatives containing a ribose derivative which is n-glycosylated to a pyrrolopyrimidine. Also called deazapurine nucleosides, they are analogs of purine nucleosides with the N atom of the purine being replaced by a C atom at position 7.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Mecanismos de acción

Propiedades químicas y físicas

• Solubilidad: DMSO : 41.67 mg/mL (142.58 mM; Need ultrasonic)