JH-X-119-01 hydrochloride - ≥95% , CAS No.2591344-30-6

CAS: 2591344-30-6 Cat. No.: J650941 Peso molecular: 488.93 PubChem CID: 131704491

GRADE & PURITY ≥95%

Storage

Store at 2-8°C,Desiccated

Shipped In

Wet ice

Descripción general

JH-X-119-01 hydrochloride is a potent and selective interleukin-1 receptor-associated kinases 1 ( IRAK1 ) inhibitor. JH-X-119-01 hydrochloride ameliorates LPS-induced sepsis in mice

In Vitro

Jh-X-119-01 (10 μM) decreases phosphorylation of NF-κB and mRNA levels of IL-6 and TNFα in LPS-treated macrophages in vitro. Jh-X-119-01 selectively inhibits IRAK1 phosphorylation. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Western Blot AnalysisCell Line: RAW 264.7 cells and THP-1 cells Concentration: 10 μM Incubation Time: 15 minutes Result: Decreased LPS (100 ng/mL)-induced phosphorylation of IκBα and NF-κB-P65.

In Vivo

Jh-X-119-01 improves survival and decreases immunopathies of LPS-challenged mice. Jh-X-119-01 increases survival of mice at the dose of 5 mg/kg body weight. Survival is further improved when the dose is increased to 10 mg/kg . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: C57BL/6 (20-22 g, male) mice Dosage: 5 mg/kg and 10 mg/kg Administration: Intraperitoneally injected; 5 days Result: Protected mice from LPS (20 mg/kg)-induced sepsis. Survival at day 5 was 13.3% in control group where septic mice were treated by vehicle, while the values were 37.5% and 56.3% for 5 mg/kg and 10 mg/kg.

Form:Solid

IC50& Target:IRAK1

Specifications

Especificaciones y pureza

≥95%

Mecanismos bioquímicos y fisiológicos

JH-X-119-01 hydrochloride is a potent and selective interleukin-1 receptor-associated kinases 1 ( IRAK1 ) inhibitor. JH-X-119-01 hydrochloride ameliorates LPS-induced sepsis in mice.

Condiciones de almacenamiento de almacenamiento

Store at 2-8°C, Desiccated

Enviado en

Wet ice

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Tipo de acción

INHIBITOR

Pureza

≥95%

Nombres e identificadores

• Sonrisas canónicas: C=CC(=O)NC1=CC=CC(=C1)C(=O)NC2=CC=C(C=C2)NC(=O)C3=CC=CC(=N3)C4=CC=NN4.Cl
• IUPAC Name: N-[4-[[3-(prop-2-enoylamino)benzoyl]amino]phenyl]-6-(1H-pyrazol-5-yl)pyridine-2-carboxamide;hydrochloride
• InChIKey: BUFHXMGSECIZAM-UHFFFAOYSA-N
• INCHI: 1S/C25H20N6O3.ClH/c1-2-23(32)27-19-6-3-5-16(15-19)24(33)28-17-9-11-18(12-10-17)29-25(34)22-8-4-7-20(30-22)21-13-14-26-31-21;/h2-15H,1H2,(H,26,31)(H,27,32)(H,28,33)(H,29,34);1H
• PubChem CID: 131704491
• Peso molecular: 488.93

Propiedades químicas y físicas

• Solubilidad: DMSO : 50 mg/mL (102.26 mM; Need ultrasonic) H2O : <0.1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble)